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Open AccessArticle

Expression and Clinical Role of Protein of Regenerating Liver (PRL) Phosphatases in Ovarian Carcinoma

by Reuven Reich 1,*, Shany Hadar 1 and Ben Davidson 2,3,*
1
Institute of Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
2
Division of Pathology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway
3
The Medical Faculty, University of Oslo, N-0316 Oslo, Norway
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2011, 12(2), 1133-1145; https://doi.org/10.3390/ijms12021133
Received: 18 November 2010 / Revised: 26 January 2011 / Accepted: 7 February 2011 / Published: 11 February 2011
(This article belongs to the Special Issue Cancer Molecules in Ovarian Cancer)
The present study analyzed the expression and clinical role of the protein of regenerating liver (PRL) phosphatase family in ovarian carcinoma. PRL1-3 mRNA expression was studied in 184 tumors (100 effusions, 57 primary carcinomas, 27 solid metastases) using RT-PCR. PRL-3 protein expression was analyzed in 157 tumors by Western blotting. PRL-1 mRNA levels were significantly higher in effusions compared to solid tumors (p View Full-Text
Keywords: ovarian carcinoma; effusion; metastasis; PRL phosphatases; survival ovarian carcinoma; effusion; metastasis; PRL phosphatases; survival
MDPI and ACS Style

Reich, R.; Hadar, S.; Davidson, B. Expression and Clinical Role of Protein of Regenerating Liver (PRL) Phosphatases in Ovarian Carcinoma. Int. J. Mol. Sci. 2011, 12, 1133-1145.

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