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Chalcones Enhance TRAIL-Induced Apoptosis in Prostate Cancer Cells

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Chair and Department of Microbiology and Immunology, Medical University of Silesia in Katowice, Jordana 19, 41 808 Zabrze, Poland
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Chair and Department of Pediatric Hematology and Oncology, Medical University of Silesia in Katowice, 3-go Maja 13, 41 800 Zabrze, Poland
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Chair and Department of Urology, Medical University of Silesia in Katowice, 3-go Maja 13, 41 800 Zabrze, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2010, 11(1), 1-13; https://doi.org/10.3390/ijms11010001
Received: 28 October 2009 / Revised: 23 November 2009 / Accepted: 23 December 2009 / Published: 24 December 2009
(This article belongs to the Special Issue Phenolics and Polyphenolics)
Chalcones exhibit chemopreventive and antitumor effects. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a naturally occurring anticancer agent that induces apoptosis in cancer cells and is not toxic to normal cells. We examined the cytotoxic and apoptotic effect of five chalcones in combination with TRAIL on prostate cancer cells. The cytotoxicity was evaluated by the MTT and LDH assays. The apoptosis was determined using flow cytometry with annexin V-FITC. Our study showed that all five tested chalcones: chalcone, licochalcone-A, isobavachalcone, xanthohumol, butein markedly augmented TRAIL-mediated apoptosis and cytotoxicity in prostate cancer cells and confirmed the significant role of chalcones in chemoprevention of prostate cancer. View Full-Text
Keywords: chalcones; TRAIL (tumor necrosis factor-related apoptosis-inducing ligand); apoptosis; chemoprevention; prostate cancer chalcones; TRAIL (tumor necrosis factor-related apoptosis-inducing ligand); apoptosis; chemoprevention; prostate cancer
MDPI and ACS Style

Szliszka, E.; Czuba, Z.P.; Mazur, B.; Sedek, L.; Paradysz, A.; Krol, W. Chalcones Enhance TRAIL-Induced Apoptosis in Prostate Cancer Cells. Int. J. Mol. Sci. 2010, 11, 1-13.

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