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Int. J. Mol. Sci. 2009, 10(7), 2935-2957;

Applications of Isothermal Titration Calorimetry in Biophysical Studies of G-quadruplexes

Dipartimento di Scienze Farmaceutiche, Università di Salerno, Via Ponte Don Melillo, 84084, Fisciano (SA), Italy
Dipartimento di Chimica, Università di Napoli Federico II, via Cintia, 80126, Napoli, Italy
Authors to whom correspondence should be addressed.
Received: 5 June 2009 / Revised: 29 June 2009 / Accepted: 29 June 2009 / Published: 2 July 2009
(This article belongs to the Special Issue Isothermal Titration Calorimetry)
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G-quadruplexes are higher-order nucleic acids structures formed by G-rich sequences that are stabilized by tetrads of hydrogen-bonded guanine bases. Recently, there has been growing interest in the study of G-quadruplexes because of their possible involvement in many biological processes. Isothermal titration calorimetry (ITC) has been proven to be a useful tool to study the energetic aspects of G-quadruplex interactions. Particularly, ITC has been applied many times to determine the thermodynamic properties of drug-quadruplex interactions to screening among various drugs and to address drug design. In the present review, we will focus on the ITC studies of G-quadruplex structures and their interaction with proteins and drugs and the most significant results will be discussed. View Full-Text
Keywords: G-quadruplex; isothermal titration calorimetry; thermodynamic; drug G-quadruplex; isothermal titration calorimetry; thermodynamic; drug
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Pagano, B.; Mattia, C.A.; Giancola, C. Applications of Isothermal Titration Calorimetry in Biophysical Studies of G-quadruplexes. Int. J. Mol. Sci. 2009, 10, 2935-2957.

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