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Molecules
Volume 31
Issue 17
10.3390/molecules31173010
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

Beneficial Role of Quercetin in Prevention and Treatment of Ischemic Stroke: Mechanisms of Action and Administration Strategies

by
Aleksandra Szychowska
1,
Mikołaj Grabarczyk
2,
Weronika Szczepańska
3,
Ewa Smolińska
4,
Andrzej Glabinski
5 and
Piotr Szpakowski
5,*
1
The Nicolaus Copernicus Provincial Multispecialty Center for Oncology and Traumatology in Lodz, 93-513 Lodz, Poland
2
Department of Clinical Pharmacology, Medical University of Lodz, 90-153 Lodz, Poland
3
J. Gromkowski Voivodship Specialist Hospital in Wroclaw, 51-149 Wroclaw, Poland
4
Central Teaching Hospital, Medical University of Lodz, 92-213 Lodz, Poland
5
Department of Neurology and Stroke, Medical University of Lodz, Zeromskiego 113 Street, 90-549 Lodz, Poland
*
Author to whom correspondence should be addressed.
Molecules 2026, 31(17), 3010; https://doi.org/10.3390/molecules31173010
Submission received: 30 July 2026 / Revised: 22 August 2026 / Accepted: 26 August 2026 / Published: 27 August 2026
(This article belongs to the Special Issue Natural Bioactive Molecules: Discovery, Mechanisms and Applications in Health and Agriculture)
Versions Notes

Abstract

Polyphenols are a complex class of plant secondary metabolites that exert numerous beneficial effects on human health. The content of individual polyphenolic compounds varies considerably among plant species. Over the past few decades, polyphenols have attracted increasing interest because of their antioxidant and antimicrobial properties. They have also demonstrated beneficial effects in the prevention and treatment of various diseases, including cardiovascular and nervous system disorders, as well as different types of neoplasms. Because polyphenols have been shown to regulate plasma lipid levels and exhibit neuroprotective potential, they have gained attention as possible therapeutic and prophylactic agents for stroke, a neurological condition with a strong cardiovascular component. Quercetin is one of the most extensively studied plant-derived compounds in this context. A growing body of preclinical evidence suggests that it may contribute to stroke prevention and significantly support post-stroke recovery. This review compiles findings from in vitro studies, animal models, and clinical trials and presents the current state of knowledge regarding the biochemical and molecular mechanisms through which quercetin protects against cerebral ischemia.
Keywords: polyphenols; quercetin; ischemic stroke; neurology polyphenols; quercetin; ischemic stroke; neurology

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MDPI and ACS Style

Szychowska, A.; Grabarczyk, M.; Szczepańska, W.; Smolińska, E.; Glabinski, A.; Szpakowski, P. Beneficial Role of Quercetin in Prevention and Treatment of Ischemic Stroke: Mechanisms of Action and Administration Strategies. Molecules 2026, 31, 3010. https://doi.org/10.3390/molecules31173010

AMA Style

Szychowska A, Grabarczyk M, Szczepańska W, Smolińska E, Glabinski A, Szpakowski P. Beneficial Role of Quercetin in Prevention and Treatment of Ischemic Stroke: Mechanisms of Action and Administration Strategies. Molecules. 2026; 31(17):3010. https://doi.org/10.3390/molecules31173010

Chicago/Turabian Style

Szychowska, Aleksandra, Mikołaj Grabarczyk, Weronika Szczepańska, Ewa Smolińska, Andrzej Glabinski, and Piotr Szpakowski. 2026. "Beneficial Role of Quercetin in Prevention and Treatment of Ischemic Stroke: Mechanisms of Action and Administration Strategies" Molecules 31, no. 17: 3010. https://doi.org/10.3390/molecules31173010

APA Style

Szychowska, A., Grabarczyk, M., Szczepańska, W., Smolińska, E., Glabinski, A., & Szpakowski, P. (2026). Beneficial Role of Quercetin in Prevention and Treatment of Ischemic Stroke: Mechanisms of Action and Administration Strategies. Molecules, 31(17), 3010. https://doi.org/10.3390/molecules31173010

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