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Open AccessReview
Enantiomerically Pure ansa-η5-Complexes of Transition Metals as an Effective Tool for Chirality Transfer
by
Pavel V. Kovyazin
Pavel V. Kovyazin ,
Leonard M. Khalilov
Leonard M. Khalilov
and
Lyudmila V. Parfenova
Lyudmila V. Parfenova *
Institute of Petrochemistry and Catalysis, Ufa Federal Research Center, Russian Academy of Sciences, 141 Prospekt Oktyabrya, 450075 Ufa, Russia
*
Author to whom correspondence should be addressed.
Molecules 2025, 30(12), 2511; https://doi.org/10.3390/molecules30122511 (registering DOI)
Submission received: 28 April 2025
/
Revised: 2 June 2025
/
Accepted: 4 June 2025
/
Published: 8 June 2025
Abstract
Chiral ansa-η5-complexes of transition metals have shown remarkable efficacy in organometallic synthesis and catalysis. Additionally, enantiomerically pure ansa-complexes hold promise for the development of novel chiral materials and pharmaceuticals. The discovery and synthesis of a diverse range of group IVB and IIIB metal complexes represents a significant milestone in the advancement of stereoselective catalytic methods for constructing metal-C, C-C, C-H, and C-heteroatom bonds. The synthesis of enantiomerically pure metallocenes can be accomplished through several strategies: utilizing optically active precursors of η5-ligands, separation of diastereomers of complexes with enantiomerically pure agents, and synthesis via the stereocontrolled reactions of enantiomerically pure σ-complexes with prochiral anions of η5-ligands. This review focuses on the analysis of various nuances of the synthesis of enantiomerically pure ansa-η5-complexes of titanium and lanthanum families. Their applicability as effective catalysts in asymmetric carbomagnesiation, carbo- and cycloalumination, oligo- and polymerization, Diels–Alder cycloaddition, reactions of zirconaaziridines, cyclization, hydrosilylation, hydrogenation, hydroamination, and other processes are highlighted as well.
Share and Cite
MDPI and ACS Style
Kovyazin, P.V.; Khalilov, L.M.; Parfenova, L.V.
Enantiomerically Pure ansa-η5-Complexes of Transition Metals as an Effective Tool for Chirality Transfer. Molecules 2025, 30, 2511.
https://doi.org/10.3390/molecules30122511
AMA Style
Kovyazin PV, Khalilov LM, Parfenova LV.
Enantiomerically Pure ansa-η5-Complexes of Transition Metals as an Effective Tool for Chirality Transfer. Molecules. 2025; 30(12):2511.
https://doi.org/10.3390/molecules30122511
Chicago/Turabian Style
Kovyazin, Pavel V., Leonard M. Khalilov, and Lyudmila V. Parfenova.
2025. "Enantiomerically Pure ansa-η5-Complexes of Transition Metals as an Effective Tool for Chirality Transfer" Molecules 30, no. 12: 2511.
https://doi.org/10.3390/molecules30122511
APA Style
Kovyazin, P. V., Khalilov, L. M., & Parfenova, L. V.
(2025). Enantiomerically Pure ansa-η5-Complexes of Transition Metals as an Effective Tool for Chirality Transfer. Molecules, 30(12), 2511.
https://doi.org/10.3390/molecules30122511
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