Diastereoselective Synthesis of (–)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acid via Morpholinone Derivatives
Abstract
:1. Introduction
2. Results
3. Conclusions
4. Experimental Section
4.1. General
4.2. (R)-(–)-N-(2,2-Diethoxyethyl)-2-phenylglycinol (47)
4.3. Synthesis of (3R,5R) and (3S,5R)-4-(2,2-diethoxyethyl)-3-(3,4-dimethoxyphenyl)-5-phenyl-1,4-oxazin-2-ones (48) and (49)
4.4. (R)-(–)-N-(2,2-Diethoxyethyl)-3,4-dimethoxyphenylglycine (50)
4.5. (R)-(–)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (1)
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Chrzanowska, M.; Grajewska, A.; Rozwadowska, M.D. Diastereoselective Synthesis of (–)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acid via Morpholinone Derivatives. Molecules 2023, 28, 3200. https://doi.org/10.3390/molecules28073200
Chrzanowska M, Grajewska A, Rozwadowska MD. Diastereoselective Synthesis of (–)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acid via Morpholinone Derivatives. Molecules. 2023; 28(7):3200. https://doi.org/10.3390/molecules28073200
Chicago/Turabian StyleChrzanowska, Maria, Agnieszka Grajewska, and Maria D. Rozwadowska. 2023. "Diastereoselective Synthesis of (–)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acid via Morpholinone Derivatives" Molecules 28, no. 7: 3200. https://doi.org/10.3390/molecules28073200