Next Article in Journal
Discovery of Barakacin and Its Derivatives as Novel Antiviral and Fungicidal Agents
Next Article in Special Issue
Synergistically Enhanced Photocatalytic Degradation by Coupling Slow-Photon Effect with Z-Scheme Charge Transfer in CdS QDs/IO-TiO2 Heterojunction
Previous Article in Journal
Hot Water Extraction of Antioxidants from Tea Leaves—Optimization of Brewing Conditions for Preparing Antioxidant-Rich Tea Drinks
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 28
Issue 7
10.3390/molecules28073031
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

External Catalyst- and Additive-Free Photo-Oxidation of Aromatic Alcohols to Carboxylic Acids or Ketones Using Air/O2

by
Meng Xu
1,
Jinhua Ou
1,*,
Kejun Luo
2,
Rongtao Liang
1,
Jian Liu
1,
Ni Li
1,
Bonian Hu
1 and
Kaijian Liu
1,*
1
School of Materials Science and Engineering, Hunan Institute of Technology, Hengyang 421002, China
2
Analytical Testing Center, Changsha Research Institute of Mining and Metallurgy Co., Ltd., Changsha 410012, China
*
Authors to whom correspondence should be addressed.
Molecules 2023, 28(7), 3031; https://doi.org/10.3390/molecules28073031
Submission received: 25 February 2023 / Revised: 21 March 2023 / Accepted: 22 March 2023 / Published: 28 March 2023
(This article belongs to the Special Issue Novel Aspects of Heterogeneous Photocatalytic Reaction)
Browse Figures
Versions Notes

Abstract

:
We present an environment-friendly and highly efficient method for the oxidation of aromatic alcohols to carboxylic acids or ketones in air via light irradiation under external catalyst-, additive-, and base-free conditions. The photoreaction system exhibits a wide substrate scope and the potential for large-scale applications. Most of the desired products are easily obtained via recrystallization and separation from low-boiling reaction medium acetone in good yields, and the products can be subsequent directly transformed without further purification.

1. Introduction

The selective oxygenation of aromatic alcohols to acids, which are significant raw materials and intermediates for the production of food preservatives, dyes, plasticizers, and sugars, is a fundamental reaction in organic synthesis [1,2,3,4,5,6]. For example, 1, 4-terephthalic acid is an important monomer in the synthesis of polyethylene terephthalate (PET, commonly known as polyester resin), whose annual global consumption amounts to about 13 million tons. Currently, various oxidizing agents, such as chromium [7] and manganese [8,9] compounds, hypervalent iodine reagents [10,11], and activated dimethyl sulfoxide (DMSO) [12], have been extensively used for this transformation. However, problems, such as toxicity, high cost, and metal waste formed by these oxidants, have limited their potential in practical applications. In comparison to other agents, O2 has received substantial attention because of its advantages of low cost, high atom efficiency, and minimal byproducts [13,14,15,16,17,18,19,20,21,22]. The selective oxygenation of alcohols to acids using O2 or air as the oxidant remains a significant challenge, possibly because aerobic oxidation of alcohols stops at the aldehyde stage and only a small fraction of the aldehydes are converted to carboxylic acids [23,24]. The oxygenation of alcohols to acids with O2 has been conducted in thermal reaction systems with external additives, such as strong bases [25], nonmetallic oxidants [26], or the adoption of transition metal catalysts [14,15,16,17,18,19,20,27,28]. In 2018, we developed a bis(methoxypropyl) ether-promoted oxidation system without an external initiator, catalyst, or base [29]. The protocol is eco-friendly and practical. However, it requires costly ether and high temperatures.
Compared to the thermal system, the photo-oxidation of aromatic alcohols to acids with air/O2 as an oxidant has attracted significant attention from those interested in the sustainable and environmentally friendly syntheses of chemicals [30,31,32,33,34,35] because O2 can be activated to form reactive oxygen species using photocatalysts [36,37]. To date, several metal-based [30] and inorganic semiconductor [32,33,34,35] photocatalysts and small molecular- or macromolecular-based organic semiconductor [31,38,39] photocatalysts have been explored for the oxygenation of alcohols to acids with O2 as the oxidant. For instance, Sugai et al. [33] reported a CBr4–Ph3P catalyzed system for the oxygenation of alcohols to the corresponding acids with a fluorescent lamp using O2 as the oxidant (Scheme 1a). In 2013, Itoh et al. [31] revealed a method for the 2-chloroanthraquinone (2-Cl-AQN)-catalyzed photo-oxidation of alcohols to obtain carboxylic acids in air under visible light irradiation (Scheme 1b). Recently, Xiao et al. [34] prepared W18O49/g-C3N4 photocatalysts to promote the transformation of benzyl alcohol to target acids with O2 (Scheme 1c). Although the systems described above exhibited several excellent characteristics, all of them require an external catalytic photosensitizer, which is obtained through either complex synthesis or expensive commercial purchase. Toxic additives, high costs, and isolation difficulties render these methods unfeasible for practical application or mass production.
Recently, several simple and eco-friendly methods for synthesizing aromatic acids by photoinduced oxidation of aldehydes were developed at room temperature [40,41]. However, there is no literature on preparation methods of aromatic acid from aromatic alcohols using O2 as the sole oxidant under external catalyst-, additive-, and base-free conditions. As the continuation of our interest in selective oxidation utilizing O2 as the oxidant and environmentally friendly synthesis protocol [29,42,43,44,45,46,47,48], we report an efficient and practical photocatalytic system for the oxygenation of aromatic alcohols to the target acids or ketones without external additives (Scheme 1d). Compared with previously reported systems, the protocol was performed successfully with excellent yields at mild reaction conditions, which exhibit a simple post-treatment and could also be applied on one-pot sequential transformation.

2. Results and Discussion

First, benzyl alcohol (1a) was used as a test substrate with O2 as the oxidant, and a 63% yield of the desired benzoic acid (3a) was placed under LED irradiation (390–395 nm, 10 W) for 24 h in MeCN (Table 1, entry 1). Based on the GC–MS results, the reaction medium had a significant impact on oxidation efficiency (entries 1–7), and the oxidation reaction produced a 74% yield of benzoic acid (3a) with acetone. As the light source has a significant influence on the oxygenation of aromatic alcohols to the corresponding acids, we investigated the effect of varying the irradiation wavelength of the light source (entries 8–15). The oxidation reaction afforded a 98% yield of (3a) at an irradiation wavelength of 367–370 nm over 24 h. Notably, there was no difference in yield when O2 was replaced with air (entry 16). However, the target product was not obtained when O2 was substituted with N2 (entry 17). In addition, the reaction was ineffective in the absence of illumination (entry 18).
The photocatalytic system is also highly efficient for the selective oxidation of a range of aromatic alcohols to produce the desired acids or ketones under the above-mentioned conditions (Table 2). In particular, benzyl alcohols substituted with electron-withdrawing or electron-donating groups (3a–3p) could be oxidized to acids in high yields, except for the strong electron-withdrawing cyano group (3j), which was obtained in a moderate yield. (This may be due to the strong electron-withdrawing effect of the cyano group, which reduces the electron cloud density of the benzene ring and benzyl radical activity, resulting in a decreased yield.) The oxidation reaction was also unaffected with the ortho-Cl (or -Me) group, and synthetically useful orthosubstituted compounds (3l and 3m) were tolerated. Notably, neither the metasubstituted compounds (3n and 3o), nor the polysubstituted compounds (3p) had a significant influence on the conversion, and all generated the target products in good yields. In addition, the oxidation of the bireactive functional substrate 1,4-phenylenedimethanol proceeded smoothly with O2 and provided the target acid in a 71% yield (3q). Significantly, various heteroaromatic and fused-aromatic alcohols also reacted smoothly to produce the expected products (3r–3u) in moderate to excellent yields. In particular, 1,2-phenylenedimethanol was also suitable for the system and offered the target product isobenzofuran-1(3H)-one (3v) in a moderate yield. Regrettably, the oxidation of fatty alcohol produced only a trace amount of the target products (3w and 3x), which may be due to the fact that the stability of primary carbon radicals produced with aliphatic alcohols is less than that of benzyl radicals from aromatic alcohols. In addition, the scope of the aromatic secondary alcohol oxidation reaction was studied under the aforementioned standard conditions. A wide range of 1-phenethylalcohols (4a–4e) and benzhydrols (4f–4j) with electron-rich or electron-poor group-substituted aromatic rings performed adequately with O2 and smoothly formed the target ketones in excellent yields. β-Substituted 1-phenethylalcohols (4k–4m) with Cl, Br, or CH2Cl groups also reacted efficiently to provide the corresponding acid in 83–90% yields. Furthermore, mandelonitrile can also be efficiently converted to benzoyl cyanide (4n), an intermediate of the herbicide metamitron. More importantly, the oxidation of cyclic secondary alcohols was effective, and the target products (4o–4q) were formed in good to excellent yields. The results presented above demonstrate the generality of the photocatalytic reaction with O2 as a reagent for the oxidation of various alcohols to the target acid.
Pharmaceutical companies show a significant interest in the late-stage structural modification of bioactive natural products. Thus, three bioactive alcohol compounds were synthesized using the proposed photocatalytic oxidation method (Scheme 2). The introduction of a carboxylic acid group to niflumic acid (3y), a nonsteroidal anti-inflammatory drug, was easily achieved through this reaction. The oxidation of bioactive secondary alcohol also proceeded smoothly with O2 under light irradiation and afforded the target natural product derivatives in good yields, including the antiphlogistic drug indometacin 4r and antilipemic agent fenofibrate 4s.
After successfully exploring the oxygenation of different aromatic alcohols, we decided to conduct large-scale oxidation experiments with 10 mmol of aromatic alcohols under the optimal standard conditions (Scheme 3a) to understand the potential synthetic value and practicability of the facile synthesis protocol. Remarkably, the target acid was obtained with the desired GC yield, which was comparable to that of the small-scale reaction. Notably, 84% and 86% yields of benzoic acid (3a) (1.03 g) and 4-bromobenzoic acid (3i) (1.73 g) were achieved, respectively, via simple recrystallization and separation. Catalyst-free photocatalytic systems are generally more popular from a green energy and industrial point of view and can satisfy demand without purification to remove byproducts and catalyst residues and achieve subsequent direct synthesis under light-driven conditions. To further demonstrate the practicality of the photocatalytic oxidation, four one-pot sequential organic syntheses starting from benzyl alcohol or 1-phenethylalcohols were performed (Scheme 3b). The crude alcohol underwent smooth hydrazidation (1a → 5a) [49], esterification (1a → 5b) [50], oximation (1a → 5c) [51], and Claisen–Schmidt condensation (1a → 5d) [52] in the desired yields.
The conversion of phenylmethanol under light irradiation over time was investigated under standard conditions (Figure 1). Phenylmethanol was converted gradually over 24 h, and only a 3% GC yield of benzoic acid was generated within the initial 6 h oxidation stage, after which phenylmethanol was added rapidly until consumed. A yield of 44% (by GC) benzaldehyde was obtained in the first 8 h, before being exhausted at a later stage of the oxidation reaction. The variation can possibly be ascribed to the fact that the alcohol was first transformed to aldehyde, and the obtained aldehyde was then oxidized to acid. In addition, the conversion rate of benzyl alcohol (1a) is slow in the early stages and then gradually increases with the formation of benzaldehyde (Figure 1). This phenomenon may be ascribed to the fact that the intermediate benzaldehyde, a carbonyl compound, can act as a triplet state photosensitizer abstracting H from the substrate to form free radicals and promote the conversion of benzyl alcohol [53].
To demonstrate the effect of light irradiation on the present method, on–off control experiments were conducted for the oxidation from benzyl alcohols to benzaldehyde and benzaldehyde to benzoic acid. As shown in Figure 2, the oxidation reaction was seriously hindered by the lack of light irradiation, indicating the light dependency of the transformations.
To further monitor the mechanism of the oxidation method, several control experiments were performed under light illumination (Scheme 4). First, the oxidation was performed with benzyl alcohols as starting materials, and the radical scavengers TEMPO or BHT were added. Only a trace amount of target product was produced ((1), (2) in Scheme 4a), which indicated that free radicals may have been generated during oxidation. Subsequently, we conducted an oxygenation with a singlet oxygen scavenger, 1,4-diazabicyclo [2.2.2]octane (DABCO), under the standard reaction conditions as oxygen molecules can be activated to singlet oxygen by photocatalysts ((3) in Scheme 4a). Oxidation only afforded benzoic acid (3a) in a 6% yield. When the reaction was trapped by the peroxy radical scavenger benzoquinone, the reaction process was also severely hampered and only a trace amount of desired product was observed ((4) in Scheme 4a). Subsequently, 9,10-dimethylanthracene (4a) underwent [4+2] cycloaddition under standard reaction conditions to achieve the target product (Scheme 4b), which further demonstrated that the oxidation of alcohols to carboxylic acid results from singlet oxygen. To further demonstrate this, electron paramagnetic resonance (EPR) experiments (see Supplementary Materials) were performed with benzyl alcohols in acetone under the standard reaction conditions, and both singlet oxygen and peroxy radical signals were trapped, confirming that singlet oxygen and peroxy radical mechanisms were involved in the oxidation system. We executed the oxidation reaction with 18O2 as the sole oxidant and found that a mixture of 16O-labeled and 18O-labeled ketone (4a) was produced (Scheme 4c), which demonstrated that both atmospheric oxygen and oxygen atoms of the C(sp3)–O bond of the alcohol were involved in the formation of the carbonyl group. To further investigate the rate determining step of the reaction system, the kinetic isotope effect of alcoholic O–H/D bonds and benzylic C(sp3)–H/D bonds were studied. The oxidation reaction was conducted with phenylmethanol (1a) and phenylmethanol-d1 (1a-d1) as the starting materials, and the k1a/k1a–d1 value was 1.02 (Scheme 4d). A mixture of phenylmethanol (1a) and phenylmethanol-d2 (1a-d2) was also oxidized, and the intermolecular kH/kD value was 3.2 (Scheme 4e). Based on the above data, we can infer that the cleavage of the benzylic C(sp3)–H bond determines the rate of the reaction system. Considering that the oxidation rate may involve the intermediate benzaldehyde (7a) formed from the oxidation of benzyl alcohols, we attempted to add a small quantity of benzaldehyde to the initial reactive reactants (Scheme 4f). The target products were obtained in a 99% GC yield within 16 h, a shorter reaction time than for previous experiments, indicating that benzaldehyde acts as a catalyst for the reaction system.
Based on the aforementioned results and reports in the literatures [53,54,55,56], a plausible mechanism for the photocatalytic oxygenation of alcohols to corresponding acids or ketones is proposed in Scheme 5. First, the ground-state triplet O2 tends to form singlet oxygen under light irradiation (see EPR experiments in the Supplementary Materials), subsequently extracting an electron from benzyl alcohol (1a), which initiates the formation of hydroperoxyl radical A and carbon-centered radical B. Then, the carbon-centered radical B transforms into peroxy radical C (see EPR experiments in the Supplementary Materials) under O2 conditions, and C reacts with benzyl alcohol (1a) to afford the peroxy compound D. The peroxy compound D was also obtained by the reaction of hydroperoxyl radical A and carbon-centered radical B. Subsequently, the peroxy compound D removes H2O2 and produces benzaldehyde. Benzaldehyde functions as a photocatalyst and transforms into a photoexcited intermediate E, which promotes the generation of carbon-centered radical B by extracting an electron from benzyl alcohol, thereby accelerating the rate of oxidation. Finally, the target product, benzoic acid (3a), was obtained via the oxidation of benzaldehyde.

3. Experimental Section

3.1. General Information

Commercially available starting materials were purchased and used without further purification. GC–MS was performed on a Shimadzu GC-MS 2010 (Kyoto, Japan). 1H NMR spectra were recorded on 400 MHz and referenced to the internal solvent signals (1H NMR: CDCl3 7.26 ppm, 1H NMR: DMSO 2.50 ppm). 13C NMR spectra were recorded on 101 MHz spectrometers referenced to the internal solvent signals (13C NMR: CDCl3 77.0 ppm, 13C NMR: 40.0 ppm). The peak information was described as brs = broad singlet, m = multiplet, q = quartet, t = triplet, d = doublet, and s = singlet. A Biotage Isolera four instrument (Tokyo, Japan) was used to purify (4a–4e, 4h–4j, 4n, and 5b).

3.2. Typical Procedure for the Synthesis of Benzoic Acid (3a)

A mixture of phenylmethanol 1a (0.5 mmol) and acetone (1.0 mL) was added to a 10 mL quartz tube with an air balloon at room temperature under the irradiation of 10 W LED lamps (367–370 nm) for 24 h. The progress was monitored by TLC or GC–MS. Upon completion, the mixture was cooled down to room temperature and transferred into a 10 mL heart-shaped bottle and concentrated in vacuum to obtain the crude products. Subsequently, a mixture of ethyl acetate and petroleum ether (1:60) was carefully drip-added to the crude product for recrystallization. After the crude product was completely dissolved, the solution was cooled to room temperature and an appropriate amount of cold petroleum ether was added under an ice bath to precipitate the product. Afterwards, the mixture was centrifuged and dried to obtain the benzoic acid 3a.

3.3. Characterization Data of Products 3a–3y, 4a–4s, and 5a–5d

  • Benzoic acid (3a) [57]: White solid (58 mg, 95%); 1H NMR (400 MHz, DMSO-d6) δ 12.96 (s, 1H), 7.95 (d, J = 7.2 Hz, 2H), 7.62 (t, J = 7.2 Hz, 1H), 7.49 (t, J = 7.6 Hz, 2H); 13C NMR (101 MHz, DMSO-d6) δ 167.8, 133.4, 131.3, 129.8, 129.1.
  • [1,1′-biphenyl]-4-carboxylic acid (3b) [58]: White solid (94 mg, 95%); 1H NMR (400 MHz, DMSO-d6) δ 13.00 (s, 1H), 8.03 (d, J = 8.4 Hz, 2H), 7.80 (d, J = 8.4 Hz, 2H), 7.73 (d, J = 8.4 Hz, 2H), 7.50 (t, J = 7.6 Hz, 2H), 7.42 (t, J = 7.6 Hz, 1H); 13C NMR (101 MHz, DMSO-d6) δ 167.7, 144.8, 139.5, 130.5, 130.1, 129.6, 128.8, 127.5, 127.3.
  • 4-methylbenzoic acid (3c) [57]: White solid (59 mg, 87%); 1H NMR (400 MHz, DMSO-d6) δ 12.80 (s, 1H), 7.83 (d, J = 8.4 Hz, 2H), 7.29 (d, J = 8.4 Hz, 2H), 2.35 (s, 3H); 13C NMR (101 MHz, DMSO-d6) δ 167.9, 143.6, 129.9, 129.7, 128.6, 21.7.
  • 4-isopropylbenzoic acid (3d) [57]: White solid (75 mg, 90%); 1H NMR (400 MHz, DMSO-d6) δ 12.81 (s, 1H), 7.87 (d, J = 8.4 Hz, 2H), 7.36 (d, J = 8.4 Hz, 2H), 3.00–2.89 (m, 1H), 1.21 (d, J = 7.2 Hz, 6H); 13C NMR (101 MHz, DMSO-d6) δ 154.1, 130.0, 127.0, 34.0, 24.1.
  • 4-(tert-butyl)benzoic acid (3e) [59]: White solid (82 mg, 92%); 1H NMR (400 MHz, DMSO-d6) δ 12.79 (s, 1H), 7.87 (d, J = 8.4 Hz, 2H), 7.50 (d, J = 8.4 Hz, 2H), 1.28 (s, 9H); 13C NMR (101 MHz, DMSO-d6) δ 167.8, 156.3, 129.7, 128.5, 125.9, 35.3, 31.4.
  • 4-(trifluoromethoxy)benzoic acid (3f) [60]: Slight yellow solid (94 mg, 91%); 1H NMR (400 MHz, DMSO-d6) δ 13.19 (s, 1H), 8.06 (d, J = 8.4 Hz, 2H), 7.46 (d, J = 8.0 Hz, 2H); 13C NMR (101 MHz, DMSO-d6) δ 166.7, 152.0, 132.2, 130.4, 121.2, 120.5 (q, J = 255.9 Hz). 19F NMR (376 MHz, CDCl3) δ −56.7.
  • 4-fluorobenzoic acid (3g) [57]: White solid (66 mg, 94%); 1H NMR (400 MHz, DMSO-d6) δ 13.06 (s, 1H), 8.02–7.98 (m, 2H), 7.34–7.29 (m, 2H); 13C NMR (101 MHz, DMSO-d6) δ 166.9, 165.4 (d, J = 249.0 Hz), 132.7 (d, J = 9.4 Hz), 127.9 (d, J = 2.8 Hz), 116.2 (d, J = 21.9 Hz); 19F NMR (376 MHz, DMSO-d6) δ −106.9.
  • 4-chlorobenzoic acid (3h) [57]: White solid (73 mg, 93%); 1H NMR (400 MHz, DMSO-d6) δ 13.20 (s, 1H), 7.94 (d, J = 8.8 Hz, 2H), 7.57 (d, J = 8.8 Hz, 2H); 13C NMR (101 MHz, DMSO-d6) δ 167.0, 138.3, 131.7, 130.1, 129.3.
  • 4-bromobenzoic acid (3i) [61]: White solid (95 mg, 95%); 1H NMR (400 MHz, DMSO-d6) δ 13.19 (s, 1H), 7.86 (d, J = 8.4 Hz, 2H), 7.70 (d, J = 8.4 Hz, 2H); 13C NMR (101 MHz, DMSO-d6) δ 167.1, 132.2, 131.8, 130.5, 127.4.
  • 4-cyanobenzoic acid (3j) [58]: Gray white solid (55 mg, 75%); 1H NMR (400 MHz, DMSO-d6) δ 13.28 (s, 1H), 8.06 (s, 2H), 8.00 (s, 2H), 13C NMR (101 MHz, DMSO-d6) δ 195.9, 133.6, 118.7, 115.5.
  • 4-(methoxycarbonyl)benzoic acid (3k) [60]: White solid (84 mg, 93%); 1H NMR (400 MHz, DMSO-d6) δ 13.36 (s, 1H), 8.05 (s, 4H), 3.87 (s, 3H); 13C NMR (101 MHz, DMSO-d6) δ 167.1, 166.1, 135.3, 133.7, 130.1, 129.9, 53.0.
  • 2-chlorobenzoic acid (3l) [62]: White solid (73 mg, 94%); 1H NMR (400 MHz, DMSO-d6) δ 13.37 (s, 1H), 7.78 (d, J = 7.6 Hz, 1H), 7.55–7.50 (m, 2H), 7.45–7.39(m, 1H); 13C NMR (101 MHz, DMSO-d6) δ 167.3, 133.1, 132.1, 132.0, 131.3, 131.1, 127.7.
  • 2-methylbenzoic acid (3m) [60]: White solid (58 mg, 86%); 1H NMR (400 MHz, DMSO-d6) δ 12.79 (s, 1H), 7.80 (d, J = 8.0 Hz, 1H), 7.43–7.39 (m, 1H), 7.26(t, J = 7.6 Hz, 2H); 13C NMR (101 MHz, DMSO-d6) δ 169.2, 139.5, 132.2, 132.0, 131.0, 130.7, 126.3, 21.8.
  • 3-chlorobenzoic acid (3n) [60]: White solid (72 mg, 92%); 1H NMR (400 MHz, DMSO-d6) δ 13.34 (s, 1H), 7.90–7.88 (m, 2H), 7.70–7.67 (m, 1H), 7.53 (t, J = 8.0 Hz, 1H); 13C NMR (101 MHz, DMSO-d6) δ 166.6, 133.9, 133.4, 133.2, 131.2, 129.4, 128.4.
  • 3-methylbenzoic acid (3o) [60]: Slight yellow solid (55 mg, 81%); 1H NMR (400 MHz, DMSO-d6) δ 12.89 (s, 1H), 7.76–7.73 (m, 2H), 7.44–7.36 (m, 2H), 2.36 (s, 3H); 13C NMR (101 MHz, DMSO-d6) δ 167.9, 138.4, 134.0, 131.2, 130.2, 129.0, 127.0, 21.3.
  • 3,4-dichlorobenzoic acid (3p) [62]: White solid (92 mg, 96%); 1H NMR (400 MHz, DMSO-d6) δ 13.50 (s, 1H), 8.04 (d, J = 2.0 Hz, 1H), 7.87 (dd, J = 8.4, 2.0 Hz, 1H), 7.76 (d, J = 8.4 Hz, 1H); 13C NMR (101 MHz, DMSO-d6) δ 165.9, 136.3, 132.0, 131.9, 131.5, 131.5, 129.8.
  • terephthalic acid (3q) [57]: White solid (59 mg, 71%); 1H NMR (400 MHz, DMSO-d6) δ 13.29 (s, 2H), 8.03 (s, 4H); 13C NMR (101 MHz, DMSO-d6) δ 167.3, 135.1, 130.1.
  • 1-naphthoic acid (3r) [57]: White solid (65 mg, 78%); 1H NMR (400 MHz, DMSO-d6) δ 13.17 (s, 1H), 8.86 (d, J = 8.4 Hz, 1H), 8.17–8.14 (m, 2H), 8.02 (d, J = 7.6 Hz, 1H), 7.66–7.57 (m, 3H); 13C NMR (101 MHz, DMSO-d6) δ 169.2, 134.0, 133.5, 131.2, 130.4, 129.1, 128.2, 128.1, 126.7, 126.0, 125.4.
  • anthracene-9-carboxylic acid (3s) [63]: Yellow solid (97 mg, 87%); 1H NMR (400 MHz, DMSO-d6) δ 13.94 (s, 1H), 8.73 (s, 1H), 8.16 (d, J = 8.4 Hz, 2H), 8.05 (d, J = 8.4 Hz, 2H), 7.64–7.57 (m, 4H); 13C NMR (101 MHz, DMSO-d6) δ 170.7, 131.0, 130.2, 129.1, 128.8, 127.6, 127.4, 126.2, 125.4.
  • isonicotinic acid (3t) [62]: White solid (45 mg, 74%); 1H NMR (400 MHz, DMSO-d6) δ 13.64 (s, 1H), 8.78 (dd, J = 4.4, 1.6 Hz, 2H), 7.81 (dd, J = 4.4 1.6 Hz, 2H); 13C NMR (101 MHz, DMSO-d6) δ 166.7, 151.1, 138.6, 123.3.
  • thiophene-2-carboxylic acid (3u) [57]: Gray white solid (54 mg, 85%); 1H NMR (400 MHz, DMSO-d6) δ 13.06 (s, 1H), 7.88 (dd, J = 4.8, 1.2 Hz, 1H), 7.73 (dd, J = 3.6, 1.2 Hz, 1H), 7.18 (dd, J = 4.8, 3.6 Hz, 1H); 13C NMR (101 MHz, DMSO-d6) δ 163.4, 135.2, 133.8, 133.7, 128.7.
  • isobenzofuran-1(3H)-one (3v) [57]: White solid (48 mg, 71%); 1H NMR (400 MHz, CDCl3) δ 7.92 (d, J = 8.0 Hz, 1H), 7.70–7.67 (m, 1H), 7.55–7.49 (m, 2H), 5.32 (s, 2H); 13C NMR (101 MHz, CDCl3) δ 171.1, 146.5, 134.0, 129.0, 125.7, 125.7, 122.1, 69.6.
  • 2-((3-(trifluoromethyl)phenyl)amino)nicotinic acid (3y) [64]: Gray white solid (96 mg, 68%); 1H NMR (400 MHz, DMSO-d6) δ 10.64 (s, 1H), 8.42 (dd, J = 4.8, 2.0 Hz, 1H), 8.28–8.26 (m, 2H), 7.84 (d, J = 8.0 Hz, 1H), 7.50 (t, J = 8.0 Hz, 1H), 7.30 (d, J = 8.0 Hz, 1H), 6.92 (dd, J = 7.6, 4.8 Hz, 1H); 13C NMR (101 MHz, DMSO-d6) δ 169.5, 155.7, 153.0, 141.2 (d, JC-F = 7.5 Hz), 130.2, 130.1 (d, JC-F = 93.5 Hz), 129.9, 124.8 (q, JC-F = 270.7 Hz), 123.9, 118.7 (JC-F = 3.9 Hz), 116.2 (JC-F = 4.0 Hz), 115.3, 108.9; 19F NMR (376 MHz, CDCl3) δ −61.2.
  • acetophenone (4a) [65]: Colorless liquid (55 mg, 91%); 1H NMR (400 MHz, DMSO-d6) δ 7.93 (d, J = 8.0 Hz, 2H), 7.53 (t, J = 7.8 Hz, 1H), 7.43 (t, J = 8.0 Hz, 2H), 2.57 (s, 3H); 13C NMR (101 MHz, DMSO-d6) δ 198.0, 136.9, 133.0, 128.4, 128.1, 26.4.
  • 1-(p-tolyl)ethanone (4b) [65]: Colorless liquid (55 mg, 82%); 1H NMR (400 MHz, DMSO-d6) δ 7.84 (d, J = 8.0 Hz, 2H), 7.24 (d, J = 8.0 Hz, 2H), 2.56 (s, 3H), 2.39 (s, 3H); 13C NMR (101 MHz, DMSO-d6) δ 197.8, 143.8, 134.6, 129.1, 128.3, 26.4, 21.5.
  • 1-(4-fluorophenyl)ethanone (4c) [65]: Colorless liquid (63 mg, 91%); 1H NMR (400 MHz, DMSO-d6) δ 7.99–7.93 (m, 2H), 7.13–7.07 (m, 2H), 2.57 (s, 3H); 13C NMR (101 MHz, DMSO-d6) δ 196.4, 165.7 (d, JC-F = 253.1), 133.5, 130.9 (d, JC-F = 9.3 Hz), 115.6 (d, JC-F = 21.7), 26.4. 19F NMR (376 MHz, CDCl3) δ −105.3.
  • 1-(4-chlorophenyl)ethanone (4d) [65]: Colorless liquid (74 mg, 96%);1H NMR (400 MHz, DMSO-d6) δ 7.87 (d, J = 8.4 Hz, 2H), 7.40 (d, J = 8.4 Hz, 2H), 2.56 (s, 3H); 13C NMR (101 MHz, DMSO-d6) δ 196.7, 139.5, 135.3, 129.6, 128.8, 26.5.
  • 1-(4-bromophenyl)ethanone (4e) [65]: Colorless liquid (97 mg, 97%); 1H NMR (400 MHz, DMSO-d6) δ 7.82 (d, J = 8.4 Hz, 2H), 7.60 (d, J = 8.4 Hz, 2H), 2.58 (s, 3H); 13C NMR (101 MHz, DMSO-d6) δ 197.0, 135.8, 131.9, 129.8, 128.3, 26.5.
  • benzophenone (4f) [66]: White solid (87 mg, 96%); 1H NMR (400 MHz, DMSO-d6) δ 7.80 (d, J = 7.2 Hz, 4H), 7.57 (t, J = 7.2 Hz, 2H), 7.47 (t, J = 7.6 Hz, 4H); 13C NMR (101 MHz, DMSO-d6) δ 196.6, 137.4, 132.3, 129.9, 128.1.
  • phenyl(p-tolyl)methanone (4g) [67]: White solid (88 mg, 90%); 1H NMR (400 MHz, DMSO-d6) δ 7.80–7.77 (m, 2H), 7.73 (d, J = 8.0 Hz, 2H), 7.60–7.56 (m, 1H), 7.47 (t, J = 7.6 Hz, 2H), 7.28 (d, J = 8.0 Hz, 2H), 2.44 (s, 3H); 13C NMR (101 MHz, DMSO-d6) δ 196.5, 143.2, 137.9, 134.8, 132.1, 130.3, 129.9, 128.9, 128.2, 21.6.
  • (4-fluorophenyl)(phenyl)methanone (4h) [67]: Colorless liquid (93 mg, 93%); 1H NMR (400 MHz, DMSO-d6) δ 7.87–7.82 (m, 2H), 7.78–7.76 (m, 2H), 7.62–7.58 (m, 1H), 7.19–7.13 (m, 2H); 13C NMR (101 MHz, DMSO-d6) δ 195.3, 165.4 (d, JC-F = 252.6 Hz), 137.5, 133.8, 133.7, 132.7, 132.6, 132.5, 129.9, 128.3, 115.5, 115.3. 19F NMR (376 MHz, CDCl3) δ −105.9.
  • (4-chlorophenyl)(phenyl)methanone (4i) [68]: Colorless liquid (103 mg, 95%); 1H NMR (400 MHz, DMSO-d6) δ 7.78–7.74 (m, 4H), 7.62–7.58 (m, 1H), 7.51–7.44 (m, 4H); 13C NMR (101 MHz, DMSO-d6) δ 195.5, 138.9, 137.2, 135.8, 132.6, 131.4, 129.9, 128.6, 128.4.
  • (4-bromophenyl)(phenyl)methanone (4j) [68]: Colorless liquid (123 mg, 94%); 1H NMR (400 MHz, DMSO-d6) δ 7.78–7.76 (m, 2H), 7.69–7.67 (m, 2H), 7.64–7.61 (m, 3H), 7.49 (t, J = 7.6 Hz, 2H); 13C NMR (101 MHz, DMSO-d6) δ 195.7, 137.1, 136.3, 132.7, 131.6, 131.6, 129.9, 128.4, 127.5.
  • 2-chloro-1-phenylethanone (4k) [69]: White solid (70 mg, 90%); 1H NMR (400 MHz, DMSO-d6) δ 7.96 (d, J = 7.6 Hz, 2H), 7.62 (t, J = 7.6 Hz, 2H), 7.50 (t, J = 7.6 Hz, 2H), 4.72 (s, 2H); 13C NMR (101 MHz, DMSO-d6) δ 191.0, 134.2, 134.0, 128.9, 128.5, 46.0.
  • 2-bromo-1-phenylethanone (4l) [69]: Grayish white solid (88 mg, 88%); 1H NMR (400 MHz, DMSO-d6) δ 7.98 (d, J = 8.4 Hz, 2H), 7.62 (t, J = 7.6 Hz, 1H), 7.50 (t, J = 7.6 Hz, 2H), 4.46 (s, 2H); 13C NMR (101 MHz, DMSO-d6) δ 191.3, 133.9, 133.9, 128.9, 128.8, 30.9.
  • 3-chloro-1-phenylpropan-1-one (4m) [70]: Grayish white solid (70 mg, 83%); 1H NMR (400 MHz, DMSO-d6) δ 7.95 (d, J = 7.6 Hz, 2H), 7.59 (t, J = 7.6 Hz, 1H), 7.47 (t, J = 7.6 Hz, 2H), 3.92 (t, J = 6.8 Hz, 2H), 3.45 (t, J = 6.8 Hz, 2H); 13C NMR (101 MHz, DMSO-d6) δ 196.6, 136.3, 133.5, 128.7, 128.0, 41.2, 38.6.
  • benzoyl cyanide (4n) [71]: Colorless liquid (60 mg, 92%); 1H NMR (400 MHz, DMSO-d6) δ 8.14 (d, J = 7.6 Hz, 2H), 7.79 (t, J = 7.6 Hz, 1H), 7.61 (t, J = 7.6 Hz, 2H); 13C NMR (101 MHz, DMSO-d6) δ 167.8, 136.8, 133.3, 130.4, 129.5, 112.7.
  • 9H-fluoren-9-one (4o) [66]: White solid (82 mg, 91%); 1H NMR (400 MHz, DMSO-d6) δ 7.65 (d, J = 7.6 Hz, 2H), 7.52–7.46 (m, 4H), 7.31–7.27 (m, 2H); 13C NMR (101 MHz, DMSO-d6) δ 193.9, 144.4, 134.7, 134.1, 129.0, 124.3, 120.3.
  • 9H-xanthen-9-one (4p) [72]: Grayish white solid (88 mg, 90%); 1H NMR (400 MHz, DMSO-d6) δ 8.35 (dd, J = 8.0, 1.6 Hz, 2H), 7.73 (td, J = 7.6, 1.6 Hz, 2H), 7.49 (d, J = 8.0 Hz, 2H), 7.40–7.36 (m, 2H); 13C NMR (101 MHz, DMSO-d6) δ 177.2, 156.1, 134.8, 126.7, 123.9, 121.8, 118.0.
  • 9H-thioxanthen-9-one (4q) [73]: Light yellow solid (93 mg, 88%); 1H NMR (400 MHz, DMSO-d6) δ 8.62 (dd, J = 8.0, 1.2 Hz, 2H), 7.65–7.57 (m, 4H), 7.51–7.47 (m, 2H); 13C NMR (101 MHz, DMSO-d6) δ 180.0, 137.3, 132.3, 129.9, 129.2, 126.3, 126.0.
  • methyl 2-(1-(4-acetylbenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate (4r) [44]: Grayish white solid (148 mg, 78%); 1H NMR (400 MHz, DMSO-d6) δ 8.06 (d, J = 8.4 Hz, 2H), 7.79 (d, J = 8.4 Hz, 2H), 6.96 (d, J = 2.4 Hz, 1H), 6.85 (d, J = 9.2 Hz, 1H), 6.65 (dd, J = 9.2, 2.4 Hz, 1H), 3.83 (s, 3H), 3.71 (s, 3H), 3.67 (s, 2H), 2.68 (s, 3H), 2.36 (s, 3H); 13C NMR (101 MHz, DMSO-d6) δ 197.3, 171.3, 168.5, 156.2, 139.8, 139.6, 135.9, 130.8, 130.7, 129.7, 128.6, 115.1, 112.9, 111.7, 101.4, 55.7, 52.2, 30.1, 26.9, 13.5.
  • isopropyl 2-(4-(4-acetylbenzoyl)phenoxy)-2-methylpropanoate (4s) [44]: White solid (153 mg, 83%); 1H NMR (400 MHz, DMSO-d6) δ 8.04 (d, J = 8.0 Hz, 2H), 7.80 (d, J = 8.0 Hz, 2H), 7.75 (d, J = 8.0 Hz, 2H), 6.86 (d, J = 8.4 Hz, 2H), 5.11–5.05 (m, 1H), 2.66 (s, 3H), 1.66 (s, 6H), 1.20 (d, J = 6.0 Hz, 6H); 13C NMR (101 MHz, DMSO-d6) δ 197.6, 194.7, 173.0, 160.0, 142.0, 139.2, 132.1, 129.9, 129.7, 128.1, 117.2, 79.4, 69.4, 26.8, 25.3, 21.5, 1.0.
  • benzohydrazide (5a) [49]: Grayish white solid (55 mg, 81%); 1H NMR (400 MHz, DMSO-d6) δ 9.79 (s, 1H), 7.83 (d, J = 7.2 Hz, 2H), 7.52–7.42 (m, 3H), 4.51 (s, 2H); 13C NMR (101 MHz, DMSO-d6) δ 166.5, 133.8, 131.6, 128.8, 127.5.
  • phenyl benzoate (5b) [50]: Colorless liquid (77 mg, 78%); 1H NMR (400 MHz, DMSO-d6) δ 8.23 (d, J = 7.2 Hz, 2H), 7.65 (t, J = 7.2 Hz, 1H), 7.53 (t, J = 7.6 Hz, 2H), 7.45 (t, J = 8.0 Hz, 2H), 7.31–7.23 (m, 3H); 13C NMR (101 MHz, DMSO-d6) δ 165.2, 150.9, 133.5, 130.1, 129.5, 129.5, 128.5, 125.9, 121.7.
  • acetophenone oxime (5c) [51]: White solid (51 mg, 75%); 1H NMR (400 MHz, DMSO-d6) δ 10.30 (s, 1H), 6.74–6.72 (m, 2H), 6.48–6.43 (m, 3H), 1.24 (s, 3H); 13C NMR (101 MHz, DMSO-d6) δ 153.4, 137.5, 129.1, 128.9, 126.1, 12.1.
  • (E)-chalcone (5d) [52]: Light yellow solid (80 mg, 77%); 1H NMR (400 MHz, DMSO-d6) δ 8.03 (d, J = 7.2 Hz, 2H), 7.82 (d, J = 16.0 Hz, 1H), 7.66–7.49 (m, 6H), 7.46–7.41 (m, 3H); 13C NMR (101 MHz, DMSO-d6) δ 190.5, 144.8, 138.2, 134.8, 132.8, 130.5, 128.9, 128.6, 128.5, 128.4, 122.1.

4. Conclusions

The results of this study present a highly efficient and practical system for the transformtion of aromatic alcohols to desired acids or ketones via light irradiation under external catalyst-, additive-, and base-free conditions. The following are notable characteristics of the developed system: (1) the photoreaction system is economical and environmentally friendly, owing to the use of air as a terminal oxidant and the reaction intermediate aldehydes as a photocatalyst. (2) A one-pot sequential transformation from aromatic alcohols to carboxylic acids or ketones was performed successfully in excellent yield, which exhibited a wide substrate scope and could also be applied on a large scale. (3) The most desired products are easily obtained via recrystallization and separation from low-boiling reaction medium acetone. More importantly, the crude products were available for subsequent direct synthesis without further purification. We believe that the developed method provides a practical light-initiated oxidation approach and could attract interest from those working in pharmaceutical chemistry and synthetic natural products chemistry.

Supplementary Materials

The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/molecules28073031/s1, Section S1: Experimental procedure; Section S2: Mechanism research; Figure S1: MS spectra of 16O-4a and 18O-4a; Figure S2. UV-Vis Spectroscopic; Figure S3: The X-band electron paramagnetic resonance (EPR) spectra of the singlet oxygen captured by TMPD; Figure S4: The X-band electron paramagnetic resonance (EPR) spectra of the peroxy radical captured by DMPO; Section S3: Comparison of methodology; Table S1: Comparison of reaction conditions and yields between this methodology and other schemes reported in the literature; Section S4: Copies of the 1H NMR and 13C NMR for compounds 3a–3y and 4a–4s. Section S5: References.

Author Contributions

M.X., J.O., N.L., R.L., J.L. and K.L. (Kaijian Liu) performed the experiments, K.L. (Kejun Luo) and B.H. analyzed the data. J.O. wrote the original draft. K.L. (Kaijian Liu) was responsible for reviewing and editing. All authors have read and agreed to the published version of the manuscript.

Funding

This research was supported by the National Natural Science Foundation of China (No. 22202067), the Research Foundation of Education Bureau of Hunan Province, China (No. 22A0620), and Open Project Fund of Materials Science and Engineering of Hunan Institute of Technology (No. KFA 20003).

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

The data presented in this study are available on request from the corresponding author.

Conflicts of Interest

The authors declare no conflict of interest.

Sample Availability

Samples of the compounds 3a–3y and 4a–4s are available from the authors.

References

  1. Cherepakhin, V.; Williams, T.J. Direct Oxidation of Primary Alcohols to Carboxylic Acids. Synthesis 2021, 53, 1023–1034. [Google Scholar]
  2. Rafiee, M.; Konz, Z.M.; Graaf, M.D.; Koolman, H.F.; Stahl, S.S. Electrochemical oxidation of alcohols and aldehydes to carboxylic acids catalyzed by 4-acetamido-TEMPO: An alternative to “Anelli” and “Pinnick” oxidations. ACS Catal. 2018, 8, 6738–6744. [Google Scholar] [CrossRef]
  3. Zhu, X.; Zhang, W.; Lin, Q.; Ye, M.; Xue, L.; Liu, J.; Wang, Y.; Cheng, H. Direct microdroplet synthesis of carboxylic acids from alcohols by preparative paper spray ionization without phase transfer catalysts. ACS Sustain. Chem. Eng. 2019, 7, 6486–6491. [Google Scholar] [CrossRef]
  4. Rafiee, M.; Alherech, M.; Karlen, S.D.; Stahl, S.S. Electrochemical aminoxyl-mediated oxidation of primary alcohols in lignin to carboxylic acids: Polymer modification and depolymerization. J. Am. Chem. Soc. 2019, 141, 15266–15276. [Google Scholar] [CrossRef] [PubMed]
  5. Yin, S.; Zheng, Q.; Chen, J.; Tu, T. Acceptorless dehydrogenation of primary alcohols to carboxylic acids by self-supported NHC-Ru single-site catalysts. J. Catal. 2022, 408, 165–172. [Google Scholar] [CrossRef]
  6. Zhang, Y.; Wang, Y.; Qian, Q.; Li, Y.; Bediako, B.B.A.; Zhang, J.; Yang, J.; Li, Z.; Han, B. Synthesis of carboxylic acids via the hydrocarboxylation of alcohols with CO2 and H2. Green Chem. 2022, 24, 1973–1977. [Google Scholar] [CrossRef]
  7. Thottathil, J.K.; Moniot, J.L.; Mueller, R.H.; Wong, M.K.; Kissick, T.P. Conversion of L-pyroglutamic acid to 4-alkyl-substituted L-prolines. The synthesis of trans-4-cyclohexyl-L-proline. J. Org. Chem. 1986, 51, 3140–3143. [Google Scholar] [CrossRef]
  8. Mahmood, A.; Robinson, G.E.; Powell, L. An improved oxidation of an alcohol using aqueous permanganate and phase-transfer catalyst. Org. Process Res. Dev. 1999, 3, 363–364. [Google Scholar] [CrossRef]
  9. Alduhaish, O.; Adil, S.F.; Assal, M.E.; Shaik, M.R.; Kuniyil, M.; Manqari, K.M.; Sekou, D.; Khan, M.; Khan, A.; Dewidar, A.Z.J.P. Synthesis and characterization of CoxOy–MnCO3 and CoxOy–Mn2O3 catalysts: A comparative catalytic assessment towards the aerial oxidation of various kinds of alcohols. Processes 2020, 8, 910. [Google Scholar] [CrossRef]
  10. Mazitschek, R.; Mülbaier, M.; Giannis, A. IBX-Mediated Oxidation of Primary Alcohols and Aldehydes To Form Carboxylic Acids. Angew. Chem. Int. Ed. 2002, 41, 4059–4061. [Google Scholar] [CrossRef]
  11. Gioia, M.L.J.M. Synthesis and preliminary evaluation of the anti-cancer activity on A549 lung cancer cells of a series of unsaturated disulfides. MedChemComm 2019, 10, 116–119. [Google Scholar]
  12. Lee, T.V. Oxidation Adjacent to Oxygen of Alcohols by Activated DMSO Methods. Compr. Org. Synth. 1991, 7, 291–303. [Google Scholar]
  13. Zhao, M.; Zhang, X.-W.; Wu, C.-D. Structural transformation of porous polyoxometalate frameworks and highly efficient biomimetic aerobic oxidation of aliphatic alcohols. ACS Catal. 2017, 7, 6573–6580. [Google Scholar] [CrossRef]
  14. Anderson, R.; Gri Ff In, K.; Johnston, P.; Alsters, P. Selective Oxidation of Alcohols to Carbonyl Compounds and Carboxylic Acids with Platinum Group Metal Catalysts. Adv. Syn. Catal. 2003, 345, 517–523. [Google Scholar] [CrossRef]
  15. Donze, C.; Korovchenko, P.; Gallezot, P.; Besson, M. Aerobic selective oxidation of (hetero) aromatic primary alcohols to aldehydes or carboxylic acids over carbon supported platinum. Appl. Catal. B-Environ. 2007, 70, 621–629. [Google Scholar] [CrossRef]
  16. Dai, Z.; Qin, L.; Jiang, H.; Qi, L.; Hua, L.; Jing, Z.; Peng, T. Ni(II)–N′NN′ pincer complexes catalyzed dehydrogenation of primary alcohols to carboxylic acids and H2 accompanied by alcohol etherification. Catal. Sci. Technol. 2017, 7, 2506–2511. [Google Scholar] [CrossRef]
  17. Könning, D.; Olbrisch, T.; Sypaseuth, F.D.; Tzschucke, C.C.; Christmann, M. Oxidation of allylic and benzylic alcohols to aldehydes and carboxylic acids. Chem. Commun. 2014, 50, 5014–5016. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  18. Fraga-Dubreuil, J.; Garcia-Verdugo, E.; Hamley, P.A.; Vaquero, E.M.; Dudd, L.M.; Pearson, I.; Housley, D.; Partenheimer, W.; Thomas, W.B.; Whiston, K. Catalytic selective partial oxidations using O2 in supercritical water: The continuous synthesis of carboxylic acids. Green Chem. 2007, 9, 1238–1245. [Google Scholar] [CrossRef]
  19. Han, L.; Xing, P.; Jiang, B. Selective aerobic oxidation of alcohols to aldehydes, carboxylic acids, and imines catalyzed by a Ag-NHC complex. Org. Lett. 2014, 16, 3428–3431. [Google Scholar] [CrossRef] [PubMed]
  20. Ahmed, M.S.; Mannel, D.S.; Root, T.W.; Stahl, S.S. Aerobic oxidation of diverse primary alcohols to carboxylic acids with a heterogeneous Pd–Bi–Te/C (PBT/C) catalyst. Org. Process Res. Dev. 2017, 21, 1388–1393. [Google Scholar] [CrossRef]
  21. Higashimoto, S.; Kitao, N.; Yoshida, N.; Sakura, T.; Azuma, M.; Ohue, H.; Sakata, Y. Selective photocatalytic oxidation of benzyl alcohol and its derivatives into corresponding aldehydes by molecular oxygen on titanium dioxide under visible light irradiation. J. Catal. 2009, 266, 279–285. [Google Scholar] [CrossRef]
  22. Ye, X.; Li, Y.; Luo, P.; He, B.; Cao, X.; Lu, T. Iron sites on defective BiOBr nanosheets: Tailoring the molecular oxygen activation for enhanced photocatalytic organic synthesis. Nano Res. 2022, 15, 1509–1516. [Google Scholar] [CrossRef]
  23. Xiao, X.; Jiang, J.; Zhang, L. Selective oxidation of benzyl alcohol into benzaldehyde over semiconductors under visible light: The case of Bi12O17Cl2 nanobelts. Appl. Catal. B-Environ. 2013, 142, 487–493. [Google Scholar] [CrossRef]
  24. Su, F.; Mathew, S.C.; Lipner, G.; Fu, X.; Antonietti, M.; Blechert, S.; Wang, X. mpg-C3N4-catalyzed selective oxidation of alcohols using O2 and visible light. J. Am. Chem. Soc. 2010, 132, 16299–16301. [Google Scholar] [CrossRef]
  25. Wang, J.; Liu, C.; Yuan, J.; Lei, A. Transition-metal-free aerobic oxidation of primary alcohols to carboxylic acids. New J. Chem. 2013, 37, 1700–1703. [Google Scholar] [CrossRef]
  26. Kim, S.; Lee, H.E.; Suh, J.M.; Mi, H.L.; Min, K. Sequential Connection of Mutually Exclusive Catalytic Reactions by a Method Controlling the Presence of an MOF Catalyst: One-Pot Oxidation of Alcohols to Carboxylic Acids. Inorg. Chem. 2020, 59, 17573–17582. [Google Scholar] [CrossRef] [PubMed]
  27. Jiang, X.; Zhang, J.; Ma, S. Iron Catalysis for Room-Temperature Aerobic Oxidation of Alcohols to Carboxylic Acids. J. Am. Chem. Soc. 2016, 138, 8344–8347. [Google Scholar] [CrossRef]
  28. Kobayashi, M.S. Remarkable Effect of Bimetallic Nanocluster Catalysts for Aerobic Oxidation of Alcohols: Combining Metals Changes the Activities and the Reaction Pathways to Aldehydes/Carboxylic Acids or Esters. J. Am. Chem. Soc. 2010, 132, 15096–15098. [Google Scholar]
  29. Liu, K.-J.; Jiang, S.; Lu, L.-H.; Tang, L.-L.; Tang, S.-S.; Tang, H.-S.; Tang, Z.; He, W.-M.; Xu, X. Bis (methoxypropyl) ether-promoted oxidation of aromatic alcohols into aromatic carboxylic acids and aromatic ketones with O2 under metal-and base-free conditions. Green Chem. 2018, 20, 3038–3043. [Google Scholar] [CrossRef]
  30. Hirashima, S.-I.; Itoh, A. Aerobic oxidation of alcohols under visible light irradiation of fluorescent lamp. Green Chem. 2007, 9, 318–320. [Google Scholar] [CrossRef]
  31. Shimada, Y.; Hattori, K.; Tada, N.; Miura, T.; Itoh, A. Facile aerobic photooxidation of alcohols using 2-chloroanthraquinone under visible light irradiation. Synthesis 2013, 45, 2684–2688. [Google Scholar] [CrossRef]
  32. Hirashima, S.-I.; Hashimoto, S.; Masaki, Y.; Itoh, A. Aerobic photo-oxidation of alcohols in the presence of a catalytic inorganic bromo source. Tetrahedron 2006, 62, 7887–7891. [Google Scholar] [CrossRef]
  33. Sugai, T.; Itoh, A. Aerobic oxidation under visible light irradiation of a fluorescent lamp with a combination of carbon tetrabromide and triphenyl phosphine. Tetrahedron Lett. 2007, 48, 9096–9099. [Google Scholar] [CrossRef]
  34. Xiao, C.; Zhang, L.; Hao, H.; Wang, W. High selective oxidation of benzyl alcohol to benzylaldehyde and benzoic acid with surface oxygen vacancies on W18O49/holey ultrathin g-C3N4 nanosheets. ACS Sustain. Chem. Eng. 2019, 7, 7268–7276. [Google Scholar] [CrossRef]
  35. Zhou, L.; Chen, M.; Wang, Y.; Su, Y.; Yang, X.; Chen, C.; Xu, J. Au/mesoporous-TiO2 as catalyst for the oxidation of alcohols to carboxylic acids with molecular oxygen in water. Appl. Catal. A-Gen. 2014, 475, 347–354. [Google Scholar] [CrossRef]
  36. Schilling, W.; Riemer, D.; Zhang, Y.; Hatami, N.; Das, S. Metal-free catalyst for visible-light-induced oxidation of unactivated alcohols using air/oxygen as an oxidant. ACS Catal. 2018, 8, 5425–5430. [Google Scholar] [CrossRef]
  37. Meng, C.; Yang, K.; Fu, X.; Yuan, R. Photocatalytic oxidation of benzyl alcohol by homogeneous CuCl2/solvent: A model system to explore the role of molecular oxygen. ACS Catal. 2015, 5, 3760–3766. [Google Scholar] [CrossRef]
  38. Qiu, C.; Wang, S.; Zuo, J.; Zhang, B.J.C. Photocatalytic CO2 reduction coupled with alcohol oxidation over porous carbon nitride. Catalysts 2022, 12, 672. [Google Scholar] [CrossRef]
  39. Chandra, S.; Jagdale, P.; Medha, I.; Tiwari, A.K.; Bartoli, M.; Nino, A.D.; Olivito, F.J.T. Biochar-Supported TiO2-Based Nanocomposites for the Photocatalytic Degradation of Sulfamethoxazole in Water—A Review. Toxics 2021, 9, 313. [Google Scholar] [CrossRef]
  40. Xu, J.; Yue, X.; He, L.; Shen, J.; Ouyang, Y.; Liang, C.; Li, W. Photoinduced protocol for aerobic oxidation of aldehydes to carboxylic acids under mild conditions. ACS Sustain. Chem. Eng. 2022, 10, 14119–14125. [Google Scholar] [CrossRef]
  41. Shi, H.; Li, J.; Wang, T.; Rudolph, M.; Hashmi, A.S.K. Catalyst-and additive-free sunlight-induced autoxidation of aldehydes to carboxylic acids. Green Chem. 2022, 24, 5835–5841. [Google Scholar] [CrossRef]
  42. Liu, K.-J.; Deng, J.-H.; Yang, J.; Gong, S.-F.; Lin, Y.-W.; He, J.-Y.; Cao, Z.; He, W.-M. Selective oxidation of (hetero) sulfides with molecular oxygen under clean conditions. Green Chem. 2020, 22, 433–438. [Google Scholar] [CrossRef]
  43. Liu, K.-J.; Wang, Z.; Lu, L.-H.; Chen, J.-Y.; Zeng, F.; Lin, Y.-W.; Cao, Z.; Yu, X.; He, W.-M. Synergistic cooperative effect of CF3SO2Na and bis (2-butoxyethyl) ether towards selective oxygenation of sulfides with molecular oxygen under visible-light irradiation. Green Chem. 2021, 23, 496–500. [Google Scholar] [CrossRef]
  44. Liu, K.-J.; Duan, Z.-H.; Zeng, X.-L.; Sun, M.; Tang, Z.; Jiang, S.; Cao, Z.; He, W.-M. Clean Oxidation of (Hetero) benzylic Csp3–H Bonds with Molecular Oxygen. ACS Sustain. Chem. Eng. 2019, 7, 10293–10298. [Google Scholar] [CrossRef]
  45. Liu, K.-J.; Zeng, T.-Y.; Zeng, J.-L.; Gong, S.-F.; He, J.-Y.; Lin, Y.-W.; Tan, J.-X.; Cao, Z.; He, W.-M. Solvent-dependent selective oxidation of 5-hydroxymethylfurfural to 2, 5-furandicarboxylic acid under neat conditions. Chin. Chem. Lett. 2019, 30, 2304–2308. [Google Scholar] [CrossRef]
  46. Ou, J.; He, S.; Wang, W.; Tan, H.; Liu, K. Highly efficient oxidative cleavage of olefins with O2 under catalyst-, initiator-and additive-free conditions. Org. Chem. Front. 2021, 8, 3102–3109. [Google Scholar] [CrossRef]
  47. Liu, K.-J.; Fu, Y.-L.; Xie, L.-Y.; Wu, C.; He, W.-B.; Peng, S.; Wang, Z.; Bao, W.-H.; Cao, Z.; Xu, X. Green and efficient: Oxidation of aldehydes to carboxylic acids and acid anhydrides with air. ACS Sustain. Chem. Eng. 2018, 6, 4916–4921. [Google Scholar] [CrossRef]
  48. Ou, J.; Tan, H.; He, S.; Wang, W.; Hu, B.; Yu, G.; Liu, K. 1, 2-Dibutoxyethane-Promoted Oxidative Cleavage of Olefins into Carboxylic Acids Using O2 Under Clean Conditions. J. Org. Chem. 2021, 86, 14974–14982. [Google Scholar] [CrossRef]
  49. Li, Z.; Liu, Y.; Bai, X.; Deng, Q.; Wang, J.; Zhang, G.; Xiao, C.; Mei, Y.; Wang, Y. SAR studies on 1, 2, 4-triazolo [3, 4-b][1,3,4] thiadiazoles as inhibitors of Mtb shikimate dehydrogenase for the development of novel antitubercular agents. RSC Adv. 2015, 5, 97089–97101. [Google Scholar] [CrossRef]
  50. Kwon, E.-M.; Kim, C.G.; Bak, J.S.; Jun, J.-G. Preparation of Benzoyloxy Benzophenone Derivatives and Their Inhibitory Effects of ICAM-1 Expression. Bull. Korean Chem. Soc. 2012, 33, 1939–1944. [Google Scholar] [CrossRef] [Green Version]
  51. Senadi, G.C.; Mutra, M.R.; Lu, T.-Y.; Wang, J.-J. Oximes as reusable templates for the synthesis of ureas and carbamates by an in situ generation of carbamoyl oximes. Green Chem. 2017, 19, 4272–4277. [Google Scholar] [CrossRef]
  52. Bashary, R.; Khatik, G.L. Design, and facile synthesis of 1, 3 diaryl-3-(arylamino) propan-1-one derivatives as the potential alpha-amylase inhibitors and antioxidants. Bioorg. Chem. 2019, 82, 156–162. [Google Scholar] [CrossRef] [PubMed]
  53. Nojima, K.; Isogami, C. Photolysis of aldrin in the presence of benzaldehyde in a solid-vapor-air system. Chem. Pharm. Bull. 1996, 44, 1580–1584. [Google Scholar] [CrossRef] [Green Version]
  54. Li, G.; Yan, Q.; Gong, X.; Dou, X.; Yang, D. Photocatalyst-Free Regioselective C–H Thiocyanation of 4-Anilinocoumarins under Visible Light. ACS Sustain. Chem. Eng. 2019, 7, 14009–14015. [Google Scholar] [CrossRef]
  55. Zhang, Y.; Teuscher, K.B.; Ji, H. Direct α-heteroarylation of amides (α to nitrogen) and ethers through a benzaldehyde-mediated photoredox reaction. Chem. Sci. 2016, 7, 2111–2118. [Google Scholar] [CrossRef] [Green Version]
  56. Xia, J.-B.; Zhu, C.; Chen, C. Visible light-promoted metal-free C–H activation: Diarylketone-catalyzed selective benzylic mono-and difluorination. J. Am. Chem. Soc. 2013, 135, 17494–17500. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  57. Yu, H.; Ru, S.; Dai, G.; Zhai, Y.; Lin, H.; Han, S.; Wei, Y. An Efficient Iron(III)-Catalyzed Aerobic Oxidation of Aldehydes in Water for the Green Preparation of Carboxylic Acids. Angew. Chem. Int. Ed. 2017, 56, 3867–3871. [Google Scholar] [CrossRef] [PubMed]
  58. Villano, R.; Acocella, M.R.; Scettri, A. Fe3O4 nanoparticles/ethyl acetoacetate system for the efficient catalytic oxidation of aldehydes to carboxylic acids. Tetrahedron Lett. 2014, 55, 2442–2445. [Google Scholar] [CrossRef]
  59. Ma, C.; Zhao, C.-Q.; Xu, X.-T.; Li, Z.-M.; Wang, X.-Y.; Zhang, K.; Mei, T.-S. Nickel-Catalyzed Carboxylation of Aryl and Heteroaryl Fluorosulfates Using Carbon Dioxide. Org. Lett. 2019, 21, 2464–2467. [Google Scholar] [CrossRef]
  60. Marcé, P.; Lynch, J.; Blacker, A.J.; Williams, J.M.J. Conversion of nitroalkanes into carboxylic acids via iodide catalysis in water. Chem. Commun. 2016, 52, 1013–1016. [Google Scholar] [CrossRef]
  61. Mishra, A.K.; Moorthy, J.N. Mechanochemical catalytic oxidations in the solid state with in situ-generated modified IBX from 3,5-di-tert-butyl-2-iodobenzoic acid (DTB-IA)/Oxone. Org. Chem. Front. 2017, 4, 343–349. [Google Scholar] [CrossRef]
  62. Yang, X.; Tang, S.; Lu, T.; Chen, C.; Zhou, L.; Su, Y.; Xu, J. Sulfonic Acid Resin–Catalyzed Oxidation of Aldehydes to Carboxylic Acids by Hydrogen Peroxide. Synth. Commun. 2013, 43, 979–985. [Google Scholar] [CrossRef]
  63. Hajimohammadi, M.; Azizi, N.; Tollabimazraeno, S.; Tuna, A.; Duchoslav, J.; Knör, G. Cobalt (II) Phthalocyanine Sulfonate Supported on Reduced Graphene Oxide (RGO) as a Recyclable Photocatalyst for the Oxidation of Aldehydes to Carboxylic Acids. Catal. Lett. 2021, 151, 36–44. [Google Scholar] [CrossRef]
  64. Yarhosseini, M.; Javanshir, S.; Dolatkhah, Z.; Dekamin, M.G. An improved solvent-free synthesis of flunixin and 2-(arylamino) nicotinic acid derivatives using boric acid as catalyst. Chem. Cent. J. 2017, 11, 124. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  65. Li, F.; Wang, N.; Lu, L.; Zhu, G. Regioselective Hydration of Terminal Alkynes Catalyzed by a Neutral Gold(I) Complex [(IPr)AuCl] and One-Pot Synthesis of Optically Active Secondary Alcohols from Terminal Alkynes by the Combination of [(IPr)AuCl] and Cp*RhCl[(R,R)-TsDPEN]. J. Org. Chem. 2015, 80, 3538–3546. [Google Scholar] [CrossRef] [PubMed]
  66. Seth, S.; Jhulki, S.; Moorthy, J.N. Catalytic and Chemoselective Oxidation of Activated Alcohols and Direct Conversion of Diols to Lactones with In Situ-Generated Bis-IBX Catalyst. Eur. J. Org. Chem. 2013, 2013, 2445–2452. [Google Scholar] [CrossRef]
  67. Mondal, M.; Bora, U. Eco-friendly Suzuki–Miyaura coupling of arylboronic acids to aromatic ketones catalyzed by the oxime-palladacycle in biosolvent 2-MeTHF. New J. Chem. 2016, 40, 3119–3123. [Google Scholar] [CrossRef]
  68. Burange, A.S.; Kale, S.R.; Zboril, R.; Gawande, M.B.; Jayaram, R.V. Magnetically retrievable MFe2O4 spinel (M = Mn, Co, Cu, Ni, Zn) catalysts for oxidation of benzylic alcohols to carbonyls. RSC Adv. 2014, 4, 6597–6601. [Google Scholar] [CrossRef]
  69. Ye, M.; Wen, Y.; Li, H.; Fu, Y.; Wang, Q. Metal-free hydration of aromatic haloalkynes to α-halomethyl ketones. Tetrahedron Lett. 2016, 57, 4983–4986. [Google Scholar] [CrossRef]
  70. Dragutan, I.; Dragutan, V.; Demonceau, A. Targeted drugs by olefin metathesis: Piperidine-based iminosugars. RSC Adv. 2012, 2, 719–736. [Google Scholar] [CrossRef]
  71. Bergonzini, G.; Cassani, C.; Lorimer-Olsson, H.; Hörberg, J.; Wallentin, C.-J. Visible-Light-Mediated Photocatalytic Difunctionalization of Olefins by Radical Acylarylation and Tandem Acylation/Semipinacol Rearrangement. Chem. Eur. J. 2016, 22, 3292–3295. [Google Scholar] [CrossRef] [PubMed]
  72. Burange, A.S.; Kale, S.R.; Jayaram, R.V. Oxidation of alkyl aromatics to ketones by tert-butyl hydroperoxide on manganese dioxide catalyst. Tetrahedron Lett. 2012, 53, 2989–2992. [Google Scholar] [CrossRef]
  73. Yu, T.; Guo, M.; Wen, S.; Zhao, R.; Wang, J.; Sun, Y.; Liu, Q.; Zhou, H. Poly(ethylene glycol) dimethyl ether mediated oxidative scission of aromatic olefins to carbonyl compounds by molecular oxygen. RSC Adv. 2021, 11, 13848–13852. [Google Scholar] [CrossRef] [PubMed]
Molecules 28 03031 sch001 550
Scheme 1. Oxidation of alcohols via photo-oxidation of alcohols (a) CBr4–Ph3P catalyzed oxidation of alcohols to the acids, (b) 2-chloroanthraquinone catalyzed oxidation of alcohols to the acids, (c) W18O49/g-C3N4 promoted the transformation of benzyl alcohol to target acids, (d) the oxygenation of aromatic alcohols to the target acids or ketones without external additives.
Scheme 1. Oxidation of alcohols via photo-oxidation of alcohols (a) CBr4–Ph3P catalyzed oxidation of alcohols to the acids, (b) 2-chloroanthraquinone catalyzed oxidation of alcohols to the acids, (c) W18O49/g-C3N4 promoted the transformation of benzyl alcohol to target acids, (d) the oxygenation of aromatic alcohols to the target acids or ketones without external additives.
Molecules 28 03031 sch001
Molecules 28 03031 sch002 550
Scheme 2. Gram-stage modification of bioactive alcohol.
Scheme 2. Gram-stage modification of bioactive alcohol.
Molecules 28 03031 sch002
Molecules 28 03031 sch003 550
Scheme 3. Large-scale and one-pot synthesis of different derivatives (a) Gram-stage synthesis of 3a and 3i, (b) one-pot synthesis of Benzoic acid and acetophenone.
Scheme 3. Large-scale and one-pot synthesis of different derivatives (a) Gram-stage synthesis of 3a and 3i, (b) one-pot synthesis of Benzoic acid and acetophenone.
Molecules 28 03031 sch003
Molecules 28 03031 g001 550
Figure 1. Time course of the oxidation of 1a to 3a.
Figure 1. Time course of the oxidation of 1a to 3a.
Molecules 28 03031 g001
Molecules 28 03031 g002 550
Figure 2. Light irradiation on–off control experiments (a) the oxidation of benzyl alcohol to benzaldehyde, (b) the oxidation of benzaldehyde to benzyl acid.
Figure 2. Light irradiation on–off control experiments (a) the oxidation of benzyl alcohol to benzaldehyde, (b) the oxidation of benzaldehyde to benzyl acid.
Molecules 28 03031 g002
Molecules 28 03031 sch004 550
Scheme 4. Control experiments (a) Radical trapped experiment; (b) Role of oxidant; (c) 18O2-labeling experiment; (d) Preparation of benzyl alcohol-OD; (e) Preparation of α, α-dideuteriobenzyl alcohol; (f) Catalytic experiment.
Scheme 4. Control experiments (a) Radical trapped experiment; (b) Role of oxidant; (c) 18O2-labeling experiment; (d) Preparation of benzyl alcohol-OD; (e) Preparation of α, α-dideuteriobenzyl alcohol; (f) Catalytic experiment.
Molecules 28 03031 sch004
Molecules 28 03031 sch005 550
Scheme 5. Proposed mechanism.
Scheme 5. Proposed mechanism.
Molecules 28 03031 sch005
Table
Table 1. Reaction conditions a.
Table 1. Reaction conditions a.
Molecules 28 03031 i001
EntryLight Source (nm)Solvent bAtmosphereYield c (%)
1390–395MeCNOxygen63
2390–395EtOHOxygen54
3390–3951,4-dioxaneOxygen21
4390–395DCEOxygen56
5390–395DMFOxygen62
6390–395DMSOOxygen63
7390–395AcetoneOxygen74
8385–390AcetoneOxygen75
9380–385AcetoneOxygen76
10375–380AcetoneOxygen80
11370–375AcetoneOxygen78
12367–370AcetoneOxygen98
13365–367AcetoneOxygen71
14395–400AcetoneOxygen64
15400–405AcetoneOxygen57
16367–370AcetoneAir98
17367–370AcetoneN20
18 Acetoneair0
a Reaction conditions: 1a (0.5 mmol), solvent (1 mL), 24 h; b DCE: 1,2-dichloroethane; DMF: N,N-dimethylacetamide; DMSO dimethyl sulfoxide; c Yields were estimated by GC–MS.
Table
Table 2. Reaction scope a.
Table 2. Reaction scope a.
Molecules 28 03031 i002
R
Molecules 28 03031 i0034-H3a95%Molecules 28 03031 i004
4-Ph3b95%
4-Me3c87%
4-iPr3d90%
4-tBu3e92%
4-OCF33f91%
4-F3g94%
4-Cl3h93%
4-Br3i95%
4-CN3j75%
4-CO2Me3k93%
2-Cl3l94%
2-Me3m86%
3-Cl3n92%
3-Me3o81%
3,4-dl-Cl3p96%
Molecules 28 03031 i0054-H4a91%Molecules 28 03031 i006
4-Me4b82%
4-F4c91%
4-Cl4d96%
4-Br 4e97%
Molecules 28 03031 i0074-H4f96%
4-Me4g90%
4-F4h93%
4-Cl4i95%
4-Br 4j94%
a Reaction conditions: 1 or 2 (0.5 mmol), acetone (1 mL), 367–370 nm 10 W LED, air balloon, 24 h.
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

Share and Cite

MDPI and ACS Style

Xu, M.; Ou, J.; Luo, K.; Liang, R.; Liu, J.; Li, N.; Hu, B.; Liu, K. External Catalyst- and Additive-Free Photo-Oxidation of Aromatic Alcohols to Carboxylic Acids or Ketones Using Air/O2. Molecules 2023, 28, 3031. https://doi.org/10.3390/molecules28073031

AMA Style

Xu M, Ou J, Luo K, Liang R, Liu J, Li N, Hu B, Liu K. External Catalyst- and Additive-Free Photo-Oxidation of Aromatic Alcohols to Carboxylic Acids or Ketones Using Air/O2. Molecules. 2023; 28(7):3031. https://doi.org/10.3390/molecules28073031

Chicago/Turabian Style

Xu, Meng, Jinhua Ou, Kejun Luo, Rongtao Liang, Jian Liu, Ni Li, Bonian Hu, and Kaijian Liu. 2023. "External Catalyst- and Additive-Free Photo-Oxidation of Aromatic Alcohols to Carboxylic Acids or Ketones Using Air/O2" Molecules 28, no. 7: 3031. https://doi.org/10.3390/molecules28073031

APA Style

Xu, M., Ou, J., Luo, K., Liang, R., Liu, J., Li, N., Hu, B., & Liu, K. (2023). External Catalyst- and Additive-Free Photo-Oxidation of Aromatic Alcohols to Carboxylic Acids or Ketones Using Air/O2. Molecules, 28(7), 3031. https://doi.org/10.3390/molecules28073031

Article Metrics

Back to TopTop