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Article

Biogenic Preparation and Characterization of Silver Nanoparticles from Seed Kernel of Mangifera indica and Their Antibacterial Potential against Shigella spp.

by
Sudha Angamuthu
1,
Selvankumar Thangaswamy
2,
Amutha Raju
3,
Fohad Mabood Husain
4,*,
Bilal Ahmed
5,*,
Nasser A. Al-Shabib
4,
Mohammed Jamal Hakeem
4,
Syed Ali Shahzad
4,
Saud A. Abudujayn
4 and
Suliman Y. Alomar
6
1
Bon Secours Arts & Science College for Women, Department of Biotechnology, Sowthapuram (PO), Near Veppadai, Namakkal 638008, Tamil Nadu, India
2
Department of Biotechnology, Mahendra Arts and Science College (Autonomous), Namakkal 637501, Tamil Nadu, India
3
Centre for Post Graduate and Research Studies, Periyar University, Salem 636001, Tamil Nadu, India
4
Department of Food Science and Nutrition, King Saud University, Riyadh 11495, Saudi Arabia
5
School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea
6
Department of Zoology, King Saud University, Riyadh 11495, Saudi Arabia
*
Authors to whom correspondence should be addressed.
Molecules 2023, 28(6), 2468; https://doi.org/10.3390/molecules28062468
Submission received: 4 October 2022 / Revised: 2 March 2023 / Accepted: 4 March 2023 / Published: 8 March 2023
(This article belongs to the Special Issue Novel Aspects in Nanomaterials for Biomedical and Environmental Applications)
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Abstract

Shigellosis is a serious foodborne diarrheal disease caused by the Shigella species. It is a critical global health issue. In developing countries, shigellosis causes most of the mortality in children below 5 years of age. Globally, around 165 million cases of diarrhea caused by Shigella are reported, which accounts for almost 1 million deaths, in which the majority are recorded in Third World nations. In this study, silver nanoparticles were synthesized using Mangifera indica kernel (MK-AgNPs) seed extracts. The biosynthesized M. indica silver nanoparticles (MK-AgNPs) were characterized using an array of spectroscopic and microscopic tools, such as UV–Vis, scanning electron microscopy, particle size analyzer, Fourier transform infrared spectroscopy, and X-ray diffractometer. The nanoparticles were spherical in shape and the average size was found to be 42.7 nm. The MK-AgNPs exhibited remarkable antibacterial activity against antibiotic-resistant clinical Shigella sp. The minimum inhibitory concentration (MIC) value of the MK-AgNPs was found to be 20 μg/mL against the multi-drug-resistant strain Shigella flexneri. The results clearly demonstrate that MK-AgNPs prepared using M. indica kernel seed extract exhibited significant bactericidal action against pathogenic Shigella species. The biosynthesized nanoparticles from mango kernel could possibly prove therapeutically useful and effective in combating the threat of shigellosis after careful investigation of its toxicity and in vivo efficacy.
Keywords: AgNPs; drug resistance; enteric pathogen; shigellosis; spectral analysis AgNPs; drug resistance; enteric pathogen; shigellosis; spectral analysis

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MDPI and ACS Style

Angamuthu, S.; Thangaswamy, S.; Raju, A.; Husain, F.M.; Ahmed, B.; Al-Shabib, N.A.; Hakeem, M.J.; Shahzad, S.A.; Abudujayn, S.A.; Alomar, S.Y. Biogenic Preparation and Characterization of Silver Nanoparticles from Seed Kernel of Mangifera indica and Their Antibacterial Potential against Shigella spp. Molecules 2023, 28, 2468. https://doi.org/10.3390/molecules28062468

AMA Style

Angamuthu S, Thangaswamy S, Raju A, Husain FM, Ahmed B, Al-Shabib NA, Hakeem MJ, Shahzad SA, Abudujayn SA, Alomar SY. Biogenic Preparation and Characterization of Silver Nanoparticles from Seed Kernel of Mangifera indica and Their Antibacterial Potential against Shigella spp. Molecules. 2023; 28(6):2468. https://doi.org/10.3390/molecules28062468

Chicago/Turabian Style

Angamuthu, Sudha, Selvankumar Thangaswamy, Amutha Raju, Fohad Mabood Husain, Bilal Ahmed, Nasser A. Al-Shabib, Mohammed Jamal Hakeem, Syed Ali Shahzad, Saud A. Abudujayn, and Suliman Y. Alomar. 2023. "Biogenic Preparation and Characterization of Silver Nanoparticles from Seed Kernel of Mangifera indica and Their Antibacterial Potential against Shigella spp." Molecules 28, no. 6: 2468. https://doi.org/10.3390/molecules28062468

APA Style

Angamuthu, S., Thangaswamy, S., Raju, A., Husain, F. M., Ahmed, B., Al-Shabib, N. A., Hakeem, M. J., Shahzad, S. A., Abudujayn, S. A., & Alomar, S. Y. (2023). Biogenic Preparation and Characterization of Silver Nanoparticles from Seed Kernel of Mangifera indica and Their Antibacterial Potential against Shigella spp. Molecules, 28(6), 2468. https://doi.org/10.3390/molecules28062468

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