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Article

Assessing the Anti-Aging and Wound Healing Capabilities of Etlingera elatior Inflorescence Extract: A Comparison of Three Inflorescence Color Varieties

by
Chutima Sinsuebpol
1,
Titpawan Nakpheng
2,
Teerapol Srichana
2,
Somchai Sawatdee
3,
Weerachai Pipatrattanaseree
4,
Kanokporn Burapapadh
1 and
Narumon Changsan
1,*
1
College of Pharmacy, Rangsit University, Pathum Thani 12000, Thailand
2
Drug Delivery System Excellence Center, Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla 90112, Thailand
3
Drug and Cosmetics Excellence Center, Walailak University, Thasala, Nakhon Si Thammarat 80160, Thailand
4
Regional Medical Sciences Center 12 Songkhla, Ministry of Public Health, Songkhla 90000, Thailand
*
Author to whom correspondence should be addressed.
Molecules 2023, 28(21), 7370; https://doi.org/10.3390/molecules28217370
Submission received: 3 October 2023 / Revised: 29 October 2023 / Accepted: 30 October 2023 / Published: 31 October 2023
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Abstract

Torch ginger, Etlingera elatior, is a Zingiberaceae plant with various red, pink, and white inflorescence. The wound healing potential and anti-aging effects of freeze-dried torch ginger inflorescence extracts (FTIEs) from three varieties were compared. The red FTIE had the highest content of phenolic, flavonoid, caffeoylquinic acid, and chlorogenic acid, followed by the white and pink FTIE. Consistent with the chemical constituents, the red FTIE demonstrated the greatest capacities for free radical scavenging, anti-tyrosinase, and anti-collagenase activity, followed by the white and pink FTIE. In cell-based studies, FTIEs displayed cytotoxicity to B16F10 melanoma cells, with the red FTIE showing the greatest activity (LC50 of 115.5 μg/mL). In contrast, the pink and the white FTIEs had less cytotoxicity impact. Nonetheless, at 1000 μg/mL, all three FTIE variants were safe on L929 fibroblasts or RAW 264.7 monocyte cells. White FTIE (500 μg/mL) exhibited the highest activity in stimulating collagen production and the greatest impact on cell migration, whereas the pink and red FTIE had a lesser effect. All FTIEs slightly suppressed the pro-inflammatory cytokines produced by lipopolysaccharide-stimulated monocytes, with no significant variation between FTIE variants. In conclusion, all FTIEs revealed promising potential for anti-aging cosmeceuticals and wound care products at specific concentrations.
Keywords: torch ginger; Etlingera elatior; anti-aging; wound healing; inflorescence color torch ginger; Etlingera elatior; anti-aging; wound healing; inflorescence color
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MDPI and ACS Style

Sinsuebpol, C.; Nakpheng, T.; Srichana, T.; Sawatdee, S.; Pipatrattanaseree, W.; Burapapadh, K.; Changsan, N. Assessing the Anti-Aging and Wound Healing Capabilities of Etlingera elatior Inflorescence Extract: A Comparison of Three Inflorescence Color Varieties. Molecules 2023, 28, 7370. https://doi.org/10.3390/molecules28217370

AMA Style

Sinsuebpol C, Nakpheng T, Srichana T, Sawatdee S, Pipatrattanaseree W, Burapapadh K, Changsan N. Assessing the Anti-Aging and Wound Healing Capabilities of Etlingera elatior Inflorescence Extract: A Comparison of Three Inflorescence Color Varieties. Molecules. 2023; 28(21):7370. https://doi.org/10.3390/molecules28217370

Chicago/Turabian Style

Sinsuebpol, Chutima, Titpawan Nakpheng, Teerapol Srichana, Somchai Sawatdee, Weerachai Pipatrattanaseree, Kanokporn Burapapadh, and Narumon Changsan. 2023. "Assessing the Anti-Aging and Wound Healing Capabilities of Etlingera elatior Inflorescence Extract: A Comparison of Three Inflorescence Color Varieties" Molecules 28, no. 21: 7370. https://doi.org/10.3390/molecules28217370

APA Style

Sinsuebpol, C., Nakpheng, T., Srichana, T., Sawatdee, S., Pipatrattanaseree, W., Burapapadh, K., & Changsan, N. (2023). Assessing the Anti-Aging and Wound Healing Capabilities of Etlingera elatior Inflorescence Extract: A Comparison of Three Inflorescence Color Varieties. Molecules, 28(21), 7370. https://doi.org/10.3390/molecules28217370

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