Fibrillization Process of Human Amyloid-Beta Protein (1–40) under a Molecular Crowding Environment Mimicking the Interior of Living Cells Using Cell Debris
Abstract
:1. Introduction
2. Results and Discussion
2.1. Observation and Structural Characterization of Deuterated Cell Debris Solution: A Model System Closely Mimicking the Intracellular Molecular Crowding Environment
2.2. Time Evolution of the Process of Fibril Formation of Human Amyloid-Beta (1–40) under a Molecular Crowded Environment Using Cell Debris Closely Mimicking the Interior of Living Cells
2.3. Modeling Analysis of the Aggregate Structure of Amyloid Fibrils in Cell Debris Solution: Possibility of the Formation of Higher-Ordered Fibril
3. Materials and Methods
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Sample Availability
References
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Hirai, M.; Arai, S.; Iwase, H. Fibrillization Process of Human Amyloid-Beta Protein (1–40) under a Molecular Crowding Environment Mimicking the Interior of Living Cells Using Cell Debris. Molecules 2023, 28, 6555. https://doi.org/10.3390/molecules28186555
Hirai M, Arai S, Iwase H. Fibrillization Process of Human Amyloid-Beta Protein (1–40) under a Molecular Crowding Environment Mimicking the Interior of Living Cells Using Cell Debris. Molecules. 2023; 28(18):6555. https://doi.org/10.3390/molecules28186555
Chicago/Turabian StyleHirai, Mitsuhiro, Shigeki Arai, and Hiroki Iwase. 2023. "Fibrillization Process of Human Amyloid-Beta Protein (1–40) under a Molecular Crowding Environment Mimicking the Interior of Living Cells Using Cell Debris" Molecules 28, no. 18: 6555. https://doi.org/10.3390/molecules28186555