Cirsiliol and Quercetin Inhibit ATP Synthesis and Decrease the Energy Balance in Methicillin-Resistant Staphylococcus aureus (MRSA) and Methicillin-Resistant Staphylococcus epidermidis (MRSE) Strains Isolated from Patients
Abstract
:1. Introduction
2. Results
2.1. Evaluation of Aerobic ATP Synthesis in MRSA_A and MRSE_178
2.2. ATP Synthesis in MRSA_A and MRSE_178 Is Sensitive to Flavonoids but Apparently Not to Oligomycin
2.3. Oligomycin Exerts Its Inhibitor Effect on ATP Synthase after a Half Hour of Incubation before the ATP Synthesis Assay
2.4. Treatment with Cirsiliol, Quercetin, and Oligomycin Reduces the Endogenous ATP Content in a Time-Dependent Manner
3. Discussion
4. Materials and Methods
4.1. Compounds
4.2. Bacterial Strains, Culture, and Treatment
4.3. ATP Synthesis Evaluation in MRSA-A and MRSE_178
4.4. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Sample Availability
References
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Ravera, S.; Tancreda, G.; Vezzulli, L.; Schito, A.M.; Panfoli, I. Cirsiliol and Quercetin Inhibit ATP Synthesis and Decrease the Energy Balance in Methicillin-Resistant Staphylococcus aureus (MRSA) and Methicillin-Resistant Staphylococcus epidermidis (MRSE) Strains Isolated from Patients. Molecules 2023, 28, 6183. https://doi.org/10.3390/molecules28176183
Ravera S, Tancreda G, Vezzulli L, Schito AM, Panfoli I. Cirsiliol and Quercetin Inhibit ATP Synthesis and Decrease the Energy Balance in Methicillin-Resistant Staphylococcus aureus (MRSA) and Methicillin-Resistant Staphylococcus epidermidis (MRSE) Strains Isolated from Patients. Molecules. 2023; 28(17):6183. https://doi.org/10.3390/molecules28176183
Chicago/Turabian StyleRavera, Silvia, Gabriele Tancreda, Luigi Vezzulli, Anna Maria Schito, and Isabella Panfoli. 2023. "Cirsiliol and Quercetin Inhibit ATP Synthesis and Decrease the Energy Balance in Methicillin-Resistant Staphylococcus aureus (MRSA) and Methicillin-Resistant Staphylococcus epidermidis (MRSE) Strains Isolated from Patients" Molecules 28, no. 17: 6183. https://doi.org/10.3390/molecules28176183