Evolution of Artificial Arginine Analogues—Fluorescent Guanidiniocarbonyl-Indoles as Efficient Oxo-Anion Binders
Abstract
:1. Introduction
2. Results and Discussion
3. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Sample Availability
References
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λabs [a] ± 5 [nm] | λem [a] [nm] | λex [a] [nm] | Stokes Shift [cm−1] | ΦF [d] ± 1 [%] | ΦF [b] ± 1 [%] | ΦF [e] ± 1 [%] | |
---|---|---|---|---|---|---|---|
1 | 296 | 344 | 299 | 4714 | - [c] | - [c] | - [c] |
2 | 314 | 400 | 299 | 6847 | 8.9 | 14.6 | 17.1 |
3 | 320 | 468 | 321 | 9882 | 2.6 | 7.1 | 15.7 |
(1) | (2) | (3) | |||||||
---|---|---|---|---|---|---|---|---|---|
Kass [M−1] | σ [M−1] | log K | Kass [M−1] | σ [M−1] | log K | Kass [M−1] | σ [M−1] | log K | |
NaOAc | 17,981 | 1220 | 4.25 | 16364 | 626 | 4.21 | 7617 | 1690 | 3.88 |
Benz | 5727 | 1831 | 3.76 | 17,339 | 1173 | 4.24 | 1376 | 273 | 3.14 |
Mphos | 4421 | 1164 | 3.65 | 7861 | 881 | 3.90 | 6919 | 1320 | 3.84 |
PPhos | 5963 | 653 | 3.78 | 5298 | 181 | 3.72 | 6562 | 2712 | 3.82 |
MSulf | 11,360 | 196 | 4.06 | 1907 | 338 | 3.28 | 10,957 | 2378 | 4.04 |
BSulf | 6258 | 2841 | 3.80 | 3565 | 665 | 3.55 | 5284 | 2202 | 3.72 |
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Sebena, D.; Rudolph, K.; Roy, B.; Wölper, C.; Nitschke, T.; Lampe, S.; Giese, M.; Voskuhl, J. Evolution of Artificial Arginine Analogues—Fluorescent Guanidiniocarbonyl-Indoles as Efficient Oxo-Anion Binders. Molecules 2022, 27, 3005. https://doi.org/10.3390/molecules27093005
Sebena D, Rudolph K, Roy B, Wölper C, Nitschke T, Lampe S, Giese M, Voskuhl J. Evolution of Artificial Arginine Analogues—Fluorescent Guanidiniocarbonyl-Indoles as Efficient Oxo-Anion Binders. Molecules. 2022; 27(9):3005. https://doi.org/10.3390/molecules27093005
Chicago/Turabian StyleSebena, Daniel, Kevin Rudolph, Bibhisan Roy, Christoph Wölper, Till Nitschke, Sarah Lampe, Michael Giese, and Jens Voskuhl. 2022. "Evolution of Artificial Arginine Analogues—Fluorescent Guanidiniocarbonyl-Indoles as Efficient Oxo-Anion Binders" Molecules 27, no. 9: 3005. https://doi.org/10.3390/molecules27093005