Next Article in Journal
Anthelmintic Effect of Leucaena leucocephala Extract and Its Active Compound, Mimosine, on Vital Behavioral Activities in Caenorhabditis elegans
Next Article in Special Issue
Evaluation of Immunotropic Activity of Iridoid-Anthocyanin Extract of Honeysuckle Berries (Lonicera caerulea L.) in the Course of Experimental Trichinellosis in Mice
Previous Article in Journal
Antibacterial Properties of Non-Modified Wool, Determined and Discussed in Relation to ISO 20645:2004 Standard
Previous Article in Special Issue
Efficient Extraction of Total Polyphenols from Apple and Investigation of Its SPF Properties
 
 
Review

A Comprehensive View on the Quercetin Impact on Colorectal Cancer

1
Doctoral School of Biomedical Sciences, University of Oradea, 410087 Oradea, Romania
2
Faculty of Medicine, “Vasile Goldis” Western University of Arad, 310045 Arad, Romania
3
Department of Surgical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410081 Oradea, Romania
4
Doctoral School of Animal Science, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, H-4032 Debrecen, Hungary
5
SC PlantExtrAKT SRL, 407059 Rădaia, Romania
6
Faculty of Pharmacy, “Vasile Goldis” Western University of Arad, 310045 Arad, Romania
7
National Institute for Economic Research “Costin C. Kiritescu” of the Romanian Academy/Centre for Mountain Economy (CE-MONT), 725700 Suceava, Romania
8
Faculty of Medicine and Pharmacy, University of Oradea, 410081 Oradea, Romania
9
Institute of Nutrition, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, H-4032 Debrecen, Hungary
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work and are both considered first author.
Academic Editor: Francesco Cacciola
Molecules 2022, 27(6), 1873; https://doi.org/10.3390/molecules27061873
Received: 26 February 2022 / Revised: 8 March 2022 / Accepted: 11 March 2022 / Published: 14 March 2022
(This article belongs to the Special Issue Natural Product-Inspired Molecules: From Weed to Remedy)
Colorectal cancer (CRC) represents the third type of cancer in incidence and second in mortality worldwide, with the newly diagnosed case number on the rise. Among the diagnosed patients, approximately 70% have no hereditary germ-line mutations or family history of pathology, thus being termed sporadic CRC. Diet and environmental factors are to date considered solely responsible for the development of sporadic CRC; therefore; attention should be directed towards the discovery of preventative actions to combat the CRC initiation, promotion, and progression. Quercetin is a polyphenolic flavonoid plant secondary metabolite with a well-characterized antioxidant activity. It has been extensively reported as an anti-carcinogenic agent in the scientific literature, and the modulated targets of quercetin have been also characterized in the context of CRC, mainly in original research publications. In this fairly comprehensive review, we summarize the molecular targets of quercetin reported to date in in vivo and in vitro CRC models, while also giving background information about the signal transduction pathways that it up- and downregulates. Among the most relevant modulated pathways, the Wnt/β-catenin, PI3K/AKT, MAPK/Erk, JNK, or p38, p53, and NF-κB have been described. With this work, we hope to encourage further quests in the elucidation of quercetin anti-carcinogenic activity as single agent, as dietary component, or as pharmaconutrient delivered in the form of plant extracts. View Full-Text
Keywords: quercetin; flavonol; polyphenol; colorectal cancer; PI3K/AKT; Wnt/β-catenin; MAPK; p53; NF-κB quercetin; flavonol; polyphenol; colorectal cancer; PI3K/AKT; Wnt/β-catenin; MAPK; p53; NF-κB
Show Figures

Figure 1

MDPI and ACS Style

Neamtu, A.-A.; Maghiar, T.-A.; Alaya, A.; Olah, N.-K.; Turcus, V.; Pelea, D.; Totolici, B.D.; Neamtu, C.; Maghiar, A.M.; Mathe, E. A Comprehensive View on the Quercetin Impact on Colorectal Cancer. Molecules 2022, 27, 1873. https://doi.org/10.3390/molecules27061873

AMA Style

Neamtu A-A, Maghiar T-A, Alaya A, Olah N-K, Turcus V, Pelea D, Totolici BD, Neamtu C, Maghiar AM, Mathe E. A Comprehensive View on the Quercetin Impact on Colorectal Cancer. Molecules. 2022; 27(6):1873. https://doi.org/10.3390/molecules27061873

Chicago/Turabian Style

Neamtu, Andreea-Adriana, Teodor-Andrei Maghiar, Amina Alaya, Neli-Kinga Olah, Violeta Turcus, Diana Pelea, Bogdan Dan Totolici, Carmen Neamtu, Adrian Marius Maghiar, and Endre Mathe. 2022. "A Comprehensive View on the Quercetin Impact on Colorectal Cancer" Molecules 27, no. 6: 1873. https://doi.org/10.3390/molecules27061873

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop