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Molecules
Volume 27
Issue 5
10.3390/molecules27051736
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Article
Peer-Review Record

Exploring Peptaibol’s Profile, Antifungal, and Antitumor Activity of Emericellipsin A of Emericellopsis Species from Soda and Saline Soils

Molecules 2022, 27(5), 1736; https://doi.org/10.3390/molecules27051736
by Anastasia E. Kuvarina 1, Irina A. Gavryushina 1, Maxim A. Sykonnikov 1, Tatiana A. Efimenko 1, Natalia N. Markelova 1, Elena N. Bilanenko 2, Sofiya A. Bondarenko 2, Lyudmila Y. Kokaeva 2, Alla V. Timofeeva 3, Marina V. Serebryakova 3, Anna S. Barashkova 4, Eugene A. Rogozhin 1,4, Marina L. Georgieva 1,2,* and Vera S. Sadykova 1,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Reviewer 3: Anonymous
Molecules 2022, 27(5), 1736; https://doi.org/10.3390/molecules27051736
Submission received: 14 February 2022 / Revised: 3 March 2022 / Accepted: 4 March 2022 / Published: 7 March 2022
(This article belongs to the Special Issue Microbial Natural Products: A Promising Source for Medical Application)

Round 1

Reviewer 1 Report

This paper has identified EmiA (an antifungal peptaibol) production from many Emericellopsis strains, and found that the extracts could suppress the growth of fungal pathogens and HCT cells. The data is solid. As for the antifungal experiments, it would be better to add several typical plate pictures.

L443, 'was caddied out', modified to 'was carried out'.

Author Response

Dear Reviewer,

Thank you for your revision. The photo of antifungal activity is included in the Supplement of the manuscript. L 433 line is corrected. 

Reviewer 2 Report

  1. Please add the unit of MIC.(Line 219)
  2.  Did you measure the effect of dEmia on the growth of HCT116 cells? 

Author Response

Dear Editor,

Thank you so much for your revision. All MIC data is included in the revision version of the manuscript. Unfortunately, in this manuscript, we did not test deEmiA on any cancer line, but we plan to do so in further experiments.

Reviewer 3 Report

Anastasia et al., described the manuscript entitled, “Exploring Peptaibol’s Profile, Antifungal and Antitumor Activity of Emericellipsin A of Emericellopsis Species from Soda and Saline Soils.” Authors described the manuscript well. In this manuscript authors isolated Emericellipsin A species and evaluated their antifungal as well antitumor activity. Interestingly it was inhibited cell growth and division by suppressing proliferation, causing cell cycle in the G0/1 and G2/M phases.

This manuscript can be accepted for publication after making grammatical corrections.

Author Response

Dear Reviewer,

Thank you so much for your revision! The grammatical mistakes of this manuscript have been corrected in some places. 

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