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The Antiviral Effect of Panax Notoginseng Polysaccharides by Inhibiting PRV Adsorption and Replication In Vitro

by 1,2,3, 1,2,3, 1,2,3, 4 and 1,2,3,5,*
1
Institutes of Agricultural Science and Technology Development, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China
2
Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China
3
Key Laboratory of Avian Bioproduct Development, Ministry of Agriculture and Rural Affairs, Yangzhou 225009, China
4
China Animal Health and Epidemiology Center, Qingdao 266000, China
5
Institutes of Agricultural Science and Technology Development, Yangzhou University, Yangzhou 225009, China
*
Author to whom correspondence should be addressed.
Academic Editor: Fabio Sonvico
Molecules 2022, 27(4), 1254; https://doi.org/10.3390/molecules27041254
Received: 13 December 2021 / Revised: 8 February 2022 / Accepted: 9 February 2022 / Published: 13 February 2022
Porcine pseudorabies (PR) is an important infectious disease caused by pseudorabies virus (PRV), which poses a major threat to food safety and security. Vaccine immunization has become the main means to prevent and control the disease. However, since 2011, a new PRV variant has caused huge economic losses to the Chinese pig industry. Panax notoginseng polysaccharides have immunomodulatory activity and other functions, but the antiviral effect has not been reported. We studied the anti-PRV activity of Panax notoginseng polysaccharides in vitro. A less cytopathic effect was observed by increasing the concentration of Panax notoginseng polysaccharides. Western blot, TCID50, plaque assay, and IFA revealed that Panax notoginseng polysaccharides could significantly inhibit the infectivity of PRV XJ5 on PK15 cells. In addition, we also found that Panax notoginseng polysaccharides blocked the adsorption and replication of PRV to PK15 cells in a dose-dependent manner. These results show that Panax notoginseng polysaccharides play an antiviral effect mainly by inhibiting virus adsorption and replication in vitro. Therefore, Panax notoginseng polysaccharides may be a potential anti-PRV agent. View Full-Text
Keywords: Panax notoginseng polysaccharides; pseudorabies virus (PRV); antiviral; infection; adsorption; replication Panax notoginseng polysaccharides; pseudorabies virus (PRV); antiviral; infection; adsorption; replication
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MDPI and ACS Style

Huan, C.; Zhou, Z.; Yao, J.; Ni, B.; Gao, S. The Antiviral Effect of Panax Notoginseng Polysaccharides by Inhibiting PRV Adsorption and Replication In Vitro. Molecules 2022, 27, 1254. https://doi.org/10.3390/molecules27041254

AMA Style

Huan C, Zhou Z, Yao J, Ni B, Gao S. The Antiviral Effect of Panax Notoginseng Polysaccharides by Inhibiting PRV Adsorption and Replication In Vitro. Molecules. 2022; 27(4):1254. https://doi.org/10.3390/molecules27041254

Chicago/Turabian Style

Huan, Changchao, Ziyan Zhou, Jingting Yao, Bo Ni, and Song Gao. 2022. "The Antiviral Effect of Panax Notoginseng Polysaccharides by Inhibiting PRV Adsorption and Replication In Vitro" Molecules 27, no. 4: 1254. https://doi.org/10.3390/molecules27041254

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