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Article

The Effect of α-Tocopherol on the Reduction of Inflammatory Processes and the Negative Effect of Acrylamide

1
Department of Pathophysiology, Institute of Medical Sciences, University of Rzeszow, 35-959 Rzeszów, Poland
2
Department of Animal Physiology and Toxicology, Pedagogical University in Cracow, 30-059 Cracow, Poland
3
Department of Biology, Institute of Medical Sciences, University of Rzeszow, Rejtana 16c, 35-959 Rzeszów, Poland
4
College of Medical Sciences, University of Rzeszow, Rejtana 16c, 35-959 Rzeszów, Poland
5
Department of Zoology and Animal Welfare, Faculty of Animal Science, University of Agriculture in Cracow, 30-059 Cracow, Poland
*
Author to whom correspondence should be addressed.
Academic Editors: Ewa Szpyrka and Magdalena Słowik-Borowiec
Molecules 2022, 27(3), 965; https://doi.org/10.3390/molecules27030965
Received: 16 December 2021 / Revised: 17 January 2022 / Accepted: 27 January 2022 / Published: 31 January 2022
(This article belongs to the Special Issue Analysis of Residues in Environmental Sample)
Our research aimed to show acrylamide’s influence on inflammatory processes, the oxidative stress it causes in the cholinergic system, and the possibility of reducing inflammation via supplementation with α-tocopherol. For this purpose, an in ovo model was used where the embryos were exposed to acrylamide, α-tocopherol and a cocktail of these substances. After 48 h of exposure, we collected brain samples and performed biochemical assays to examine the effect of the chosen substances on oxidative stress (malondialdehyde-MDA and reduced glutathione-GSH) and acetylcholinesterase activity (AChE). The results showed that acrylamide decreased AChE activity in the examined brain samples by about 25% in comparison to the control group, and this effect was decreased by administering α-tocopherol. The concentration of malondialdehyde significantly increased in the group given acrylamide, while, in the group with α-tocopherol, the observed concentration was lower in comparison to the control group. Moreover, a decrease in glutathione concentration was observed after the administration of acrylamide; however, the protective effect of α-tocopherol was only slightly visible in this case. In conclusion, α-tocopherol minimizes the harmful effects of acrylamide on AchE, and it can minimize the concentration of MDA. View Full-Text
Keywords: cholinergic system; inflammation; tocopherol cholinergic system; inflammation; tocopherol
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MDPI and ACS Style

Kopańska, M.; Batoryna, M.; Banaś-Ząbczyk, A.; Błajda, J.; Lis, M.W. The Effect of α-Tocopherol on the Reduction of Inflammatory Processes and the Negative Effect of Acrylamide. Molecules 2022, 27, 965. https://doi.org/10.3390/molecules27030965

AMA Style

Kopańska M, Batoryna M, Banaś-Ząbczyk A, Błajda J, Lis MW. The Effect of α-Tocopherol on the Reduction of Inflammatory Processes and the Negative Effect of Acrylamide. Molecules. 2022; 27(3):965. https://doi.org/10.3390/molecules27030965

Chicago/Turabian Style

Kopańska, Marta, Marta Batoryna, Agnieszka Banaś-Ząbczyk, Joanna Błajda, and Marcin W. Lis. 2022. "The Effect of α-Tocopherol on the Reduction of Inflammatory Processes and the Negative Effect of Acrylamide" Molecules 27, no. 3: 965. https://doi.org/10.3390/molecules27030965

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