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Review

Mechanistic Basis for the Role of Phytochemicals in Inflammation-Associated Chronic Diseases

1
College of Pharmacy, Oregon State University, Portland, OR 97201, USA
2
School of Pharmacy, Pacific University, Hillsboro, OR 97123, USA
3
School of Pharmacy, West Coast University, Los Angeles, CA 90004, USA
*
Author to whom correspondence should be addressed.
Brianna Cote contributed to this article while employed at Oregon State University. The views expressed are her own and do not represent the views of the Food and Drug Administration or the United States Government.
Academic Editor: Hyun-Ock Pae
Molecules 2022, 27(3), 781; https://doi.org/10.3390/molecules27030781
Received: 24 December 2021 / Revised: 14 January 2022 / Accepted: 21 January 2022 / Published: 25 January 2022
Chronic inflammatory diseases occur in a large portion of the population and are associated with a poor diet. Key natural products found in fruits and vegetables may assist in lowering inflammation associated with chronic diseases such as obesity, diabetes, cardiovascular diseases, and cancer. This review seeks to examine the roles of several natural products, resveratrol (RES), quercetin (QUE), curcumin (CUR), piperine (PIP), epigallocatechin gallate (EGCG), and gingerol (GIN), in their ability to attenuate inflammatory markers in specific diseases states. Additionally, we will discuss findings in past and ongoing clinical trials, detail possible phytochemical–drug interactions, and provide a brief resource for researchers and healthcare professionals on natural product and supplement regulation as well as names of databases with information on efficacy, indications, and natural product–drug interactions. As diet and over-the-counter supplement use are modifiable factors and patients are interested in using complementary and alternative therapies, understanding the mechanisms by which natural products have demonstrated efficacy and the types of drugs they interact with and knowing where to find information on herbs and supplements is important for practicing healthcare providers and researchers interested in this field. View Full-Text
Keywords: natural products; complementary and alternative therapies; inflammation associated diseases; natural product drug interactions natural products; complementary and alternative therapies; inflammation associated diseases; natural product drug interactions
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MDPI and ACS Style

Cote, B.; Elbarbry, F.; Bui, F.; Su, J.W.; Seo, K.; Nguyen, A.; Lee, M.; Rao, D.A. Mechanistic Basis for the Role of Phytochemicals in Inflammation-Associated Chronic Diseases. Molecules 2022, 27, 781. https://doi.org/10.3390/molecules27030781

AMA Style

Cote B, Elbarbry F, Bui F, Su JW, Seo K, Nguyen A, Lee M, Rao DA. Mechanistic Basis for the Role of Phytochemicals in Inflammation-Associated Chronic Diseases. Molecules. 2022; 27(3):781. https://doi.org/10.3390/molecules27030781

Chicago/Turabian Style

Cote, Brianna, Fawzy Elbarbry, Fiona Bui, Joe W. Su, Karen Seo, Arthur Nguyen, Max Lee, and Deepa A. Rao. 2022. "Mechanistic Basis for the Role of Phytochemicals in Inflammation-Associated Chronic Diseases" Molecules 27, no. 3: 781. https://doi.org/10.3390/molecules27030781

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