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by
  • Lihui Chen 1,2,3,4,†,
  • Fulai Yuan 5,† and
  • Wei Zhang 1,2,3,4,*
  • et al.

Reviewer 1: Anonymous Reviewer 2: Dalia M. Kopustinskiene

Round 1

Reviewer 1 Report

I have reviewed the paper entitled “Potential Role of Host Microbiome in Areca Nut3 associated Carcinogenesis and Addiction”. The paper contains very systematic information, however, needs the below modification.

Comments

 

1.      The abstract is too short, it should be more decorated.

2.      Make sure to update the introduction by citing the relevant published paper in 2020 and 2021.

3.      The data provided in table 1 is not sufficient, the phytochemistry part should be revised strongly.

4.      One more decorated figure should be designed.  

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Reviewer 2 Report

The topic is interesting, however, there are major revisions needed before the publication. As the article is about areca nut compounds, please provide table with areca nut main polyphenolic constituents - other plants could be left as "main source", but the table should deal with areca nut, not polyphenolic compounds in general. According to the data provided, the worst carcinogenic and addictive effects of areca nut are due to alkaloids present in this plant. Please provide formulas of the main alcaloids and describe their effects if known.

Extensive English editing is needed, as there are spelling errors left, e.g. L36 - Austrilia, etc.

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Round 2

Reviewer 2 Report

Please reorganize the table 1 in the readable way, that all the formulas provided are readable

Please redraw the table 2 as the table is presented as major classes of polyphenolic compounds, then leaves and fruits are given in the table as them? The first column is plant, then resveratrol is given as plant?

Why do you state that it is impossible to provide formulas of main alcaloids, as they are freely available on PubChem. Please, make a figure using their formulas:

Arecoline:

https://pubchem.ncbi.nlm.nih.gov/compound/Arecoline

Arecaidine:

https://pubchem.ncbi.nlm.nih.gov/compound/10355

Guvacoline:

https://pubchem.ncbi.nlm.nih.gov/compound/160492

Guvacine:

https://pubchem.ncbi.nlm.nih.gov/compound/3532

Author Response

Please see the attachment

Author Response File: Author Response.pdf