Next Article in Journal
Musa sp. Leaves Extract Ameliorates the Hepato-Renal Toxicities Induced by Cadmium in Mice
Previous Article in Journal
Separation of Rare-Earth Elements from Nitrate Solutions by Solvent Extraction Using Mixtures of Methyltri-n-octylammonium Nitrate and Tri-n-butyl Phosphate
 
 
Article

Application of Deep Eutectic Solvents in the Synthesis of Substituted 2-Mercaptoquinazolin-4(3H)-Ones: A Comparison of Selected Green Chemistry Methods

1
Faculty of Food Technology Osijek, Josip Juraj Strossmayer University of Osijek, Franje Kuhača 18, HR-31000 Osijek, Croatia
2
Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev Trg 19, HR-10000 Zagreb, Croatia
3
Faculty of Chemistry and Technology, University of Split, Ruđera Boškovića 35, HR-21000 Split, Croatia
*
Authors to whom correspondence should be addressed.
Academic Editors: Vito Capriati and Joaquín García-Álvarez
Molecules 2022, 27(2), 558; https://doi.org/10.3390/molecules27020558
Received: 20 December 2021 / Revised: 7 January 2022 / Accepted: 14 January 2022 / Published: 16 January 2022
In this study, deep eutectic solvents (DESs) were used as green and eco-friendly media for the synthesis of substituted 2-mercaptoquinazolin-4(3H)-ones from different anthranilic acids and aliphatic or aromatic isothiocyanates. A model reaction on anthranilic acid and phenyl isothiocyanate was performed in 20 choline chloride-based DESs at 80 °C to find the best solvent. Based on the product yield, choline chloride:urea (1:2) DES was found to be the most effective, while DESs acted both as solvents and catalysts. Desired compounds were prepared with moderate to good yields using stirring, microwave-assisted, and ultrasound-assisted synthesis. Significantly, higher yields were obtained with mixing and ultrasonication (16–76%), while microwave-induced synthesis showed lower effectiveness (13–49%). The specific contribution of this research is the use of DESs in combination with the above-mentioned green techniques for the synthesis of a wide range of derivatives. The structures of the synthesized compounds were confirmed by 1H and 13C NMR spectroscopy. View Full-Text
Keywords: deep eutectic solvents; 2-mercaptoquinazolin-4(3H)-one; microwave-assisted synthesis; ultrasound-assisted synthesis; green chemistry deep eutectic solvents; 2-mercaptoquinazolin-4(3H)-one; microwave-assisted synthesis; ultrasound-assisted synthesis; green chemistry
Show Figures

Figure 1

MDPI and ACS Style

Komar, M.; Kraljević, T.G.; Jerković, I.; Molnar, M. Application of Deep Eutectic Solvents in the Synthesis of Substituted 2-Mercaptoquinazolin-4(3H)-Ones: A Comparison of Selected Green Chemistry Methods. Molecules 2022, 27, 558. https://doi.org/10.3390/molecules27020558

AMA Style

Komar M, Kraljević TG, Jerković I, Molnar M. Application of Deep Eutectic Solvents in the Synthesis of Substituted 2-Mercaptoquinazolin-4(3H)-Ones: A Comparison of Selected Green Chemistry Methods. Molecules. 2022; 27(2):558. https://doi.org/10.3390/molecules27020558

Chicago/Turabian Style

Komar, Mario, Tatjana Gazivoda Kraljević, Igor Jerković, and Maja Molnar. 2022. "Application of Deep Eutectic Solvents in the Synthesis of Substituted 2-Mercaptoquinazolin-4(3H)-Ones: A Comparison of Selected Green Chemistry Methods" Molecules 27, no. 2: 558. https://doi.org/10.3390/molecules27020558

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop