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Pharmacokinetics Study of Jin-Gu-Lian Prescription and Its Core Drug Pair (Sargentodoxa cuneata (Oliv.) Rehd. et W and Alangium chinense (Lour.) Harms) by UPLC-MS/MS

by 1,†, 1,2,†, 1,2, 1,2, 2,3, 1, 1,* and 1,*
1
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang 550004, China
2
School of Pharmacy, Guizhou Medical University, Guiyang 550004, China
3
Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Medical University, Guiyang 550004, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: In-Soo Yoon
Molecules 2022, 27(13), 4025; https://doi.org/10.3390/molecules27134025
Received: 11 May 2022 / Revised: 9 June 2022 / Accepted: 13 June 2022 / Published: 23 June 2022
Jin-Gu-Lian (JGL) is traditionally used by Miao for the treatment of rheumatism arthralgia. At the same time, the combination of Sargentodoxa cuneata (Oliv.) Rehd. et W (SC) and Alangium chinense (Lour.) Harms (AC), the core drug pair (CDP) in the formula of JGL, is used at high frequencies in many Miao medicine prescriptions for rheumatic diseases. However, previous research lacks the pharmacokinetic study of JGL, and study on the compatibility of its CDP with other medicinal herbs in the formula is needed. This study aims to establish a simple, rapid, and sensitive Ultra Performance Liquid Chromatography Tandem Mass Spectrometry (UPLC-MS/MS) method for the simultaneous determination of four main bioactive components of JGL in rat plasma, including Salidroside (Sal), Anabasine (Ana), Chlorogenic Acid (CA), and Protocatechuic Acid (PCA), and compare the pharmacokinetic properties of two groups of rats after being orally administrated with JGL and its CDP extracts, respectively. The results showed that area under the plasma concentration-time curve (AUC), mean retention time (MRT), and clearance rate (CL), of Sal, Ana, CA and PCA in the two groups of rats were changed in different degrees. The CDP combined with other drugs could significantly increase the absorption of Sal and Ana, prolong its retention time in vivo, and may accelerate the absorption rate of CA and PCA. This indicated that the combination of CDP and other herbs may affect the pharmacokinetics process of active components in vivo, increase the exposure and bioavailability of compounds in the JGL group, and prolong the retention time, which may be the reason why JGL has a better inhibitory effect on inflammatory cytokines, providing a viable orientation for the compatibility investigation of herb medicines. View Full-Text
Keywords: Jin-Gu-Lian; core drug pair; pharmacokinetics; UPLC-MS/MS Jin-Gu-Lian; core drug pair; pharmacokinetics; UPLC-MS/MS
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MDPI and ACS Style

Zheng, L.; Zhou, T.; Liu, H.; Zhou, Z.; Chi, M.; Li, Y.; Gong, Z.; Huang, Y. Pharmacokinetics Study of Jin-Gu-Lian Prescription and Its Core Drug Pair (Sargentodoxa cuneata (Oliv.) Rehd. et W and Alangium chinense (Lour.) Harms) by UPLC-MS/MS. Molecules 2022, 27, 4025. https://doi.org/10.3390/molecules27134025

AMA Style

Zheng L, Zhou T, Liu H, Zhou Z, Chi M, Li Y, Gong Z, Huang Y. Pharmacokinetics Study of Jin-Gu-Lian Prescription and Its Core Drug Pair (Sargentodoxa cuneata (Oliv.) Rehd. et W and Alangium chinense (Lour.) Harms) by UPLC-MS/MS. Molecules. 2022; 27(13):4025. https://doi.org/10.3390/molecules27134025

Chicago/Turabian Style

Zheng, Lin, Ting Zhou, Hui Liu, Zuying Zhou, Mingyan Chi, Yueting Li, Zipeng Gong, and Yong Huang. 2022. "Pharmacokinetics Study of Jin-Gu-Lian Prescription and Its Core Drug Pair (Sargentodoxa cuneata (Oliv.) Rehd. et W and Alangium chinense (Lour.) Harms) by UPLC-MS/MS" Molecules 27, no. 13: 4025. https://doi.org/10.3390/molecules27134025

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