The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis

Sredoja Tisma, Vesna; Bulimbasic, Stela; Galesic Ljubanovic, Danica; Galesic, Kresimir; Morovic-Vergles, Jadranka; Mitrovic, Josko; Uchida, Koji; Tatzber, Franz; Zarkovic, Neven; Jaganjac, Morana

doi:10.3390/molecules26082344

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The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis

Vesna Sredoja Tisma

¹,

Stela Bulimbasic

²,

Danica Galesic Ljubanovic

^3,4,

Kresimir Galesic

⁵,

Jadranka Morovic-Vergles

⁶

⁶

⁷,

⁸,

⁹

and

Morana Jaganjac

^9,*

Polyclinic Department of Dermatology and Venereology, Dubrava University Hospital, 10040 Zagreb, Croatia

Department of Pathology and Cytology, University Hospital Centre Zagreb, 10000 Zagreb, Croatia

Department of Pathology, School of Medicine Zagreb, University of Zagreb, 10000 Zagreb, Croatia

⁴

Department of Nephropathology and Electron Microscopy, Dubrava University Hospital, 10040 Zagreb, Croatia

⁵

Division of Nephrology, Department of Internal Medicine, Dubrava University Hospital, University of Zagreb School of Medicine, 10040 Zagreb, Croatia

⁶

Division of Clinical Immunology, Allergology and Rheumatology, Department of Internal Medicine, Dubrava University Hospital, University of Zagreb School of Medicine, 10040 Zagreb, Croatia

⁷

Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan

⁸

Omnignostica Gmbh & Co. KG, 2465 Höflein, Austria

⁹

Laboratory for Oxidative Stress, Division of Molecular Medicine Rudjer Boskovic Institute, 10000 Zagreb, Croatia

Author to whom correspondence should be addressed.

Academic Editor: Diego Muñoz-Torrero

Molecules 2021, 26(8), 2344; https://doi.org/10.3390/molecules26082344

Received: 15 March 2021 / Revised: 2 April 2021 / Accepted: 13 April 2021 / Published: 17 April 2021

(This article belongs to the Collection Molecular Medicine)

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Abstract

Small-vessel vasculitis (SVV) is the inflammation of the vessel wall that can result in hemorrhage and/or ischemia. Among the histological findings in SVV are increased infiltrating neutrophils, which, due to their oxidative burst and myeloperoxidase activity, release excessive reactive oxygen species, triggering a chain reaction of lipid peroxidation and yielding reactive aldehydes such as acrolein. The implication of oxidative stress in the pathogenesis of SVV was studied, focusing on acrolein immunohistochemistry in the affected skin vessels and systemic stress response. Samples from SVV patients and healthy subjects were collected and analyzed for total serum peroxides, total antioxidant capacity, inflammatory and immunological parameters, as well as for the presence of acrolein–protein adducts in the skin tissue specimens. The obtained data showed that systemic redox homeostasis and iron metabolism are altered in SVV patients. Possible biomarkers in the evaluation of oxidative status, disease activity and prevalence were indicated. Furthermore, a strong correlation between the accumulation of acrolein–protein adducts in the skin and the progression of the disease was revealed. Thus, the results of this study demonstrate that SVV is not only associated with systemic oxidative stress but also with tissue-specific oxidative stress that promotes acrolein formation and protein modification correlating with the severity of cutaneous vasculitis. View Full-Text

Keywords: vasculitis; oxidative stress; lipid peroxidation; acrolein

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MDPI and ACS Style

Sredoja Tisma, V.; Bulimbasic, S.; Galesic Ljubanovic, D.; Galesic, K.; Morovic-Vergles, J.; Mitrovic, J.; Uchida, K.; Tatzber, F.; Zarkovic, N.; Jaganjac, M. The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis. Molecules 2021, 26, 2344. https://doi.org/10.3390/molecules26082344

AMA Style

Sredoja Tisma V, Bulimbasic S, Galesic Ljubanovic D, Galesic K, Morovic-Vergles J, Mitrovic J, Uchida K, Tatzber F, Zarkovic N, Jaganjac M. The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis. Molecules. 2021; 26(8):2344. https://doi.org/10.3390/molecules26082344

Chicago/Turabian Style

Sredoja Tisma, Vesna, Stela Bulimbasic, Danica Galesic Ljubanovic, Kresimir Galesic, Jadranka Morovic-Vergles, Josko Mitrovic, Koji Uchida, Franz Tatzber, Neven Zarkovic, and Morana Jaganjac. 2021. "The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis" Molecules 26, no. 8: 2344. https://doi.org/10.3390/molecules26082344

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