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Review

Engineering Polymeric Nanosystems against Oral Diseases

1
Division of Oral Medicine, UCL Eastman Dental Institute, Bloomsbury Campus, Rockefeller Building, 21 University Street, London WC1E 6DE, UK
2
Department of Pharmaceutical Sciences (DISFARM), National Institute of Molecular Genetics (INGM), Via G. Balzaretti 9, 20133 Milan, Italy
3
National Institute of Molecular Genetics (INGM), Via F. Sforza 35, 20122 Milan, Italy
4
Department of Mathematics and Physics “Ennio De Giorgi”, Via Monteroni, c/o Campus Ecotekne, 73100 Lecce, Italy
5
Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, Royal Free Hospital, UCL Medical School, Rowland Hill Street, London NW3 2PF, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Horia Iovu
Molecules 2021, 26(8), 2229; https://doi.org/10.3390/molecules26082229
Received: 1 March 2021 / Revised: 31 March 2021 / Accepted: 6 April 2021 / Published: 13 April 2021
(This article belongs to the Special Issue Application of Novel Polymeric Nanoparticles in Nanomedicine)
Nanotechnology and nanoparticles (NPs) are at the forefront of modern research, particularly in the case of healthcare therapeutic applications. Polymeric NPs, specifically, hold high promise for these purposes, including towards oral diseases. Careful optimisation of the production of polymeric NPs, however, is required to generate a product which can be easily translated from a laboratory environment to the actual clinical usage. Indeed, considerations such as biocompatibility, biodistribution, and biodegradability are paramount. Moreover, a pre-clinical assessment in adequate in vitro, ex vivo or in vivo model is also required. Last but not least, considerations for the scale-up are also important, together with an appropriate clinical testing pathway. This review aims to eviscerate the above topics, sourcing at examples from the recent literature to put in context the current most burdening oral diseases and the most promising polymeric NPs which would be suitable against them. View Full-Text
Keywords: nanotechnology; polymeric nanoparticles; oral diseases; oral medicine; caries; restorative dentistry; endodontology; periodontology; oral cancer; pre-clinical models; clinical studies nanotechnology; polymeric nanoparticles; oral diseases; oral medicine; caries; restorative dentistry; endodontology; periodontology; oral cancer; pre-clinical models; clinical studies
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MDPI and ACS Style

Mercadante, V.; Scarpa, E.; De Matteis, V.; Rizzello, L.; Poma, A. Engineering Polymeric Nanosystems against Oral Diseases. Molecules 2021, 26, 2229. https://doi.org/10.3390/molecules26082229

AMA Style

Mercadante V, Scarpa E, De Matteis V, Rizzello L, Poma A. Engineering Polymeric Nanosystems against Oral Diseases. Molecules. 2021; 26(8):2229. https://doi.org/10.3390/molecules26082229

Chicago/Turabian Style

Mercadante, Valeria, Edoardo Scarpa, Valeria De Matteis, Loris Rizzello, and Alessandro Poma. 2021. "Engineering Polymeric Nanosystems against Oral Diseases" Molecules 26, no. 8: 2229. https://doi.org/10.3390/molecules26082229

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