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Article

Cryptotympana pustulata Extract and Its Main Active Component, Oleic Acid, Inhibit Ovalbumin-Induced Allergic Airway Inflammation through Inhibition of Th2/GATA-3 and Interleukin-17/RORγt Signaling Pathways in Asthmatic Mice

1
Institute of Traditional Medicine & Bioscience, Daejeon University, Daejeon 34520, Korea
2
Department of Herbology, College of Korean Medicine, Sangji University, 83 Sangjidae-gil, Wonju 26339, Korea
3
Department of Pharmacology, College of Korean Medicine, Sangji University, 83 Sangjidae-gil, Wonju 26339, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Arduino Mangoni
Molecules 2021, 26(7), 1854; https://doi.org/10.3390/molecules26071854
Received: 25 February 2021 / Revised: 24 March 2021 / Accepted: 24 March 2021 / Published: 25 March 2021
(This article belongs to the Special Issue New Insights into Anti-allergic, Anti-asthmatic Materials)
Cicadae Periostracum (CP), derived from the slough of Cryptotympana pustulata, has been used as traditional medicine in Korea and China because of its diaphoretic, antipyretic, anti-inflammatory, antioxidant, and antianaphylactic activities. The major bioactive compounds include oleic acid (OA), palmitic acid, and linoleic acid. However, the precise therapeutic mechanisms underlying its action in asthma remain unclear. The objective of this study was to determine the antiasthmatic effects of CP in an ovalbumin (OVA)-induced asthmatic mouse model. CP and OA inhibited the inflammatory cell infiltration, airway hyperresponsiveness (AHR), and production of interleukin (IL)7 and Th2 cytokines (IL-5) in the bronchoalveolar lavage fluid and OVA-specific imunoglobin E (IgE) in the serum. The gene expression of IL-5, IL-13, CCR3, MUC5AC, and COX-2 was attenuated in lung tissues. CP and OA might inhibit the nuclear translocation of GATA-binding protein 3 (GATA-3) and retinoic acid receptor-related orphan receptor γt (RORγt) via the upregulation of forkhead box p3 (Foxp3), thereby preventing the activation of GATA-3 and RORγt. In the in vitro experiment, a similar result was observed for Th2 and GATA-3. These results suggest that CP has the potential for the treatment of asthma via the inhibition of the GATA-3/Th2 and IL-17/RORγt signaling pathways. View Full-Text
Keywords: Cicadae Periostracum; asthma; IL-5; IL-13; GATA-3; RORγt Cicadae Periostracum; asthma; IL-5; IL-13; GATA-3; RORγt
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MDPI and ACS Style

Kim, S.-H.; Hong, J.-H.; Yang, W.-K.; Kim, H.-J.; An, H.-J.; Lee, Y.-C. Cryptotympana pustulata Extract and Its Main Active Component, Oleic Acid, Inhibit Ovalbumin-Induced Allergic Airway Inflammation through Inhibition of Th2/GATA-3 and Interleukin-17/RORγt Signaling Pathways in Asthmatic Mice. Molecules 2021, 26, 1854. https://doi.org/10.3390/molecules26071854

AMA Style

Kim S-H, Hong J-H, Yang W-K, Kim H-J, An H-J, Lee Y-C. Cryptotympana pustulata Extract and Its Main Active Component, Oleic Acid, Inhibit Ovalbumin-Induced Allergic Airway Inflammation through Inhibition of Th2/GATA-3 and Interleukin-17/RORγt Signaling Pathways in Asthmatic Mice. Molecules. 2021; 26(7):1854. https://doi.org/10.3390/molecules26071854

Chicago/Turabian Style

Kim, Seung-Hyung, Jung-Hee Hong, Won-Kyung Yang, Hyo-Jung Kim, Hyo-Jin An, and Young-Cheol Lee. 2021. "Cryptotympana pustulata Extract and Its Main Active Component, Oleic Acid, Inhibit Ovalbumin-Induced Allergic Airway Inflammation through Inhibition of Th2/GATA-3 and Interleukin-17/RORγt Signaling Pathways in Asthmatic Mice" Molecules 26, no. 7: 1854. https://doi.org/10.3390/molecules26071854

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