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Article

Exopolysaccharide from Lactobacillus plantarum HY7714 Protects against Skin Aging through Skin–Gut Axis Communication

R&BD Center, Korea Yakult Co Ltd., 22, Giheungdanji-ro 24 beon-gil, Giheung-gu, Gyeonggi-do 17086, Korea
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First author.
Academic Editor: Juraj Majtan
Molecules 2021, 26(6), 1651; https://doi.org/10.3390/molecules26061651
Received: 23 February 2021 / Revised: 10 March 2021 / Accepted: 12 March 2021 / Published: 16 March 2021
(This article belongs to the Special Issue Natural Products and Skin Diseases)
Skin aging occurs inevitably as a natural result of physiological changes over time. In particular, solar exposure of the skin accounts for up to 90% of skin damage. Numerous studies have examined the ability of dietary constituents to prevent skin aging, and recent research has emphasized the role of functional probiotics in intestinal function and skin aging. However, the mechanism of the interactions between aging and probiotics has not been elucidated yet. The aim of this study was to determine the role of exopolysaccharides (EPS) produced by lactic acid bacteria (LAB) identified as Lactobacillus plantarum HY7714 in regulating tight junctions in intestinal epithelial cells and increasing moisture retention in human dermal fibroblasts cells. We observed that HY7714 EPS controlled intestinal tight junctions in Caco-2 cells by upregulating the genes encoding occludin-1 (OCL-1) and zonula occluden-1 (ZO-1). In addition, HY7714 EPS effectively improved UVB-induced cytotoxicity and hydration capacity in HS68 cells by downregulating production of metalloproteinases (MMPs) and reactive oxygen species (ROS). In summary, HY7714 EPS is an effective anti-aging molecule in skin and may have therapeutic potential against skin diseases and UVB-induced damage. Therefore, HY7714 EPS serves as a functional substance in skin–gut axis communication. View Full-Text
Keywords: exopolysaccharide; lactic acid bacteria; skin aging; photoaging; Caco-2 cells; HS68 cells exopolysaccharide; lactic acid bacteria; skin aging; photoaging; Caco-2 cells; HS68 cells
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MDPI and ACS Style

Lee, K.; Kim, H.J.; Kim, S.A.; Park, S.-D.; Shim, J.-J.; Lee, J.-L. Exopolysaccharide from Lactobacillus plantarum HY7714 Protects against Skin Aging through Skin–Gut Axis Communication. Molecules 2021, 26, 1651. https://doi.org/10.3390/molecules26061651

AMA Style

Lee K, Kim HJ, Kim SA, Park S-D, Shim J-J, Lee J-L. Exopolysaccharide from Lactobacillus plantarum HY7714 Protects against Skin Aging through Skin–Gut Axis Communication. Molecules. 2021; 26(6):1651. https://doi.org/10.3390/molecules26061651

Chicago/Turabian Style

Lee, Kippeum, Hyeon J. Kim, Soo A. Kim, Soo-Dong Park, Jae-Jung Shim, and Jung-Lyoul Lee. 2021. "Exopolysaccharide from Lactobacillus plantarum HY7714 Protects against Skin Aging through Skin–Gut Axis Communication" Molecules 26, no. 6: 1651. https://doi.org/10.3390/molecules26061651

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