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Selected Thoughts on Hydrophobicity in Drug Design

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Academic Editors: Libor Grubhoffer and Masanori Baba
Molecules 2021, 26(4), 875; https://doi.org/10.3390/molecules26040875
Received: 25 January 2021 / Revised: 3 February 2021 / Accepted: 5 February 2021 / Published: 7 February 2021
The fundamental aim of drug design in research and development is to invent molecules with selective affinity towards desired disease-associated targets. At the atomic loci of binding surfaces, systematic structural variations can define affinities between drug candidates and biomolecules, and thereby guide the optimization of safety, efficacy and pharmacologic properties. Hydrophobic interaction between biomolecules and drugs is integral to binding affinity and specificity. Examples of antiviral drug discovery are discussed. View Full-Text
Keywords: hydrophobic interaction; drug design; acyclic nucleoside phosphonates; nucleotide antivirals hydrophobic interaction; drug design; acyclic nucleoside phosphonates; nucleotide antivirals
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MDPI and ACS Style

Lou, L.L.; Martin, J.C. Selected Thoughts on Hydrophobicity in Drug Design. Molecules 2021, 26, 875. https://doi.org/10.3390/molecules26040875

AMA Style

Lou LL, Martin JC. Selected Thoughts on Hydrophobicity in Drug Design. Molecules. 2021; 26(4):875. https://doi.org/10.3390/molecules26040875

Chicago/Turabian Style

Lou, Lillian L., and John C. Martin. 2021. "Selected Thoughts on Hydrophobicity in Drug Design" Molecules 26, no. 4: 875. https://doi.org/10.3390/molecules26040875

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