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Molecules
Volume 26
Issue 4
10.3390/molecules26040828
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Review

SUMO and Transcriptional Regulation: The Lessons of Large-Scale Proteomic, Modifomic and Genomic Studies

by
Mathias Boulanger
1,2,
Mehuli Chakraborty
1,2,
Denis Tempé
1,2,
Marc Piechaczyk
1,2,* and
Guillaume Bossis
1,2,*
1
Institut de Génétique Moléculaire de Montpellier (IGMM), University of Montpellier, CNRS, Montpellier, France
2
Equipe Labellisée Ligue Contre le Cancer, Paris, France
*
Authors to whom correspondence should be addressed.
Academic Editors: Cécile Polge and Alfred Vertegaal
Molecules 2021, 26(4), 828; https://doi.org/10.3390/molecules26040828
Received: 12 January 2021 / Revised: 29 January 2021 / Accepted: 1 February 2021 / Published: 5 February 2021
(This article belongs to the Special Issue Ubiquitin and Ubiquitin-Like Proteins: From Basic Mechanisms to Human Disorders)
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Abstract

One major role of the eukaryotic peptidic post-translational modifier SUMO in the cell is transcriptional control. This occurs via modification of virtually all classes of transcriptional actors, which include transcription factors, transcriptional coregulators, diverse chromatin components, as well as Pol I-, Pol II- and Pol III transcriptional machineries and their regulators. For many years, the role of SUMOylation has essentially been studied on individual proteins, or small groups of proteins, principally dealing with Pol II-mediated transcription. This provided only a fragmentary view of how SUMOylation controls transcription. The recent advent of large-scale proteomic, modifomic and genomic studies has however considerably refined our perception of the part played by SUMO in gene expression control. We review here these developments and the new concepts they are at the origin of, together with the limitations of our knowledge. How they illuminate the SUMO-dependent transcriptional mechanisms that have been characterized thus far and how they impact our view of SUMO-dependent chromatin organization are also considered. View Full-Text
Keywords: SUMO; transcription; transcription factors; transcriptional coregulators; chromatin; chromatin modification; heterochromatin SUMO; transcription; transcription factors; transcriptional coregulators; chromatin; chromatin modification; heterochromatin
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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MDPI and ACS Style

Boulanger, M.; Chakraborty, M.; Tempé, D.; Piechaczyk, M.; Bossis, G. SUMO and Transcriptional Regulation: The Lessons of Large-Scale Proteomic, Modifomic and Genomic Studies. Molecules 2021, 26, 828. https://doi.org/10.3390/molecules26040828

AMA Style

Boulanger M, Chakraborty M, Tempé D, Piechaczyk M, Bossis G. SUMO and Transcriptional Regulation: The Lessons of Large-Scale Proteomic, Modifomic and Genomic Studies. Molecules. 2021; 26(4):828. https://doi.org/10.3390/molecules26040828

Chicago/Turabian Style

Boulanger, Mathias, Mehuli Chakraborty, Denis Tempé, Marc Piechaczyk, and Guillaume Bossis. 2021. "SUMO and Transcriptional Regulation: The Lessons of Large-Scale Proteomic, Modifomic and Genomic Studies" Molecules 26, no. 4: 828. https://doi.org/10.3390/molecules26040828

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