Review Reports

Round 1

Reviewer 1 Report

The manuscript entitled as " Medicinal use of testosterone and related steroids revisited " is suitable for publication. As the authors present the structures of the well known derivatives (androgens etc), I would suggest they make some comments about the SAR, eg methyltestosterone is a testosterone derivative that bears a methyl group at the 17 alpha position which  increases bioavailability. Minor spelling problems should be revised.

Author Response

Thank you very much for your review, please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

This manuscript describes the medicinal use of compounds based on the structure and biological activity of testosterone, and discusses some of the newer androgenic-anabolic compounds, such as selective androgen receptor modulators, whose efficacy/adverse-effect profiles have not been sufficiently established and may pose a greater risk than conventional androgenic-anabolic agents.

This subject is worthy of review and update. The manuscript is a good piece of work; it is well written and structured, and the information is clearly and succinctly presented. I suggest its publication in Molecules.

Authors should pay attention to the deformation errors on pages 104 and 360.

Author Response

Thank you very much for your review, please see the attachment.

Author Response File: Author Response.docx