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Review

Current Updates on Naturally Occurring Compounds Recognizing SARS-CoV-2 Druggable Targets

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Dipartimento di Scienze della Salute, Università “Magna Græcia” di Catanzaro, Campus “S. Venuta”, Viale Europa, 88100 Catanzaro, Italy
2
Net4Science Academic Spin-Off, Università “Magna Græcia” di Catanzaro, Campus “S. Venuta”, Viale Europa, 88100 Catanzaro, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Diego Muñoz-Torrero and Beatriz De Pascual-Teresa
Molecules 2021, 26(3), 632; https://doi.org/10.3390/molecules26030632
Received: 31 December 2020 / Revised: 20 January 2021 / Accepted: 21 January 2021 / Published: 26 January 2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified in China as the etiologic agent of the recent COVID-19 pandemic outbreak. Due to its high transmissibility, this virus quickly spread throughout the world, causing considerable health issues. The scientific community exerted noteworthy efforts to obtain therapeutic solutions for COVID-19, and new scientific networks were constituted. No certified drugs to efficiently inhibit the virus were identified, and the development of de-novo medicines requires approximately ten years of research. Therefore, the repurposing of natural products could be an effective strategy to handle SARS-CoV-2 infection. This review aims to update on current status of the natural occurring compounds recognizing SARS-CoV-2 druggable targets. Among the clinical trials actually recruited, some natural compounds are ongoing to examine their potential role to prevent and to treat the COVID-19 infection. Many natural scaffolds, including alkaloids, terpenes, flavonoids, and benzoquinones, were investigated by in-silico, in-vitro, and in-vivo approaches. Despite the large data set obtained by a computational approach, experimental evidences in most cases are not available. To fill this gap, further efforts to validate these results are required. We believe that an accurate investigation of naturally occurring compounds may provide insights for the potential treatment of COVID-19 patients. View Full-Text
Keywords: SARS-CoV-2; natural products; drug repurposing; multi-targeting; COVID-19; in silico; in vitro; in vivo; clinical trials SARS-CoV-2; natural products; drug repurposing; multi-targeting; COVID-19; in silico; in vitro; in vivo; clinical trials
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MDPI and ACS Style

Romeo, I.; Mesiti, F.; Lupia, A.; Alcaro, S. Current Updates on Naturally Occurring Compounds Recognizing SARS-CoV-2 Druggable Targets. Molecules 2021, 26, 632. https://doi.org/10.3390/molecules26030632

AMA Style

Romeo I, Mesiti F, Lupia A, Alcaro S. Current Updates on Naturally Occurring Compounds Recognizing SARS-CoV-2 Druggable Targets. Molecules. 2021; 26(3):632. https://doi.org/10.3390/molecules26030632

Chicago/Turabian Style

Romeo, Isabella; Mesiti, Francesco; Lupia, Antonio; Alcaro, Stefano. 2021. "Current Updates on Naturally Occurring Compounds Recognizing SARS-CoV-2 Druggable Targets" Molecules 26, no. 3: 632. https://doi.org/10.3390/molecules26030632

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