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Green Synthesis of Gold Nanoparticles Using Plant Extracts as Beneficial Prospect for Cancer Theranostics

Department of Bioengineering & Technology, GUIST, Gauhati University, Guwahati 781014, Assam, India
SIAN Institute, Association for Biodiversity Conservation and Research (ABC), Balasore 756001, Odisha, India
Department of Biotechnology, Academy of Management and Information Technology, Khordha 752057, Odisha, India
Malda Polytechnic, West Bengal State Council of Technical Education, Government of West Benga, Malda 732102, West Bengal, India
Department of Food Technology and Biochemical Engineering, Jadavpur University, Kolkata 700038, West Bengal, India
Department of Chemistry, Gauhati University, Guwahati 781014, Assam, India
Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad (Prayagraj) 211004, Uttar Pradesh, India
School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia
Faculty of Agro Based Industry, Universiti Malaysia Kelantan, Jeli 17600, Kelantan, Malaysia
Haematology Department, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian 16150, Kelantan, Malaysia
Authors to whom correspondence should be addressed.
Each authors contributed equally to this work.
Academic Editors: Li Li and Nilesh Nirmal
Molecules 2021, 26(21), 6389;
Received: 1 October 2021 / Revised: 19 October 2021 / Accepted: 19 October 2021 / Published: 22 October 2021
(This article belongs to the Special Issue Recent Progress of Nanomaterials in Healthcare)
Gold nanoparticles (AuNPs) have been widely explored and are well-known for their medical applications. Chemical and physical synthesis methods are a way to make AuNPs. In any case, the hunt for other more ecologically friendly and cost-effective large-scale technologies, such as environmentally friendly biological processes known as green synthesis, has been gaining interest by worldwide researchers. The international focus on green nanotechnology research has resulted in various nanomaterials being used in environmentally and physiologically acceptable applications. Several advantages over conventional physical and chemical synthesis (simple, one-step approach to synthesize, cost-effectiveness, energy efficiency, and biocompatibility) have drawn scientists’ attention to exploring the green synthesis of AuNPs by exploiting plants’ secondary metabolites. Biogenic approaches, mainly the plant-based synthesis of metal nanoparticles, have been chosen as the ideal strategy due to their environmental and in vivo safety, as well as their ease of synthesis. In this review, we reviewed the use of green synthesized AuNPs in the treatment of cancer by utilizing phytochemicals found in plant extracts. This article reviews plant-based methods for producing AuNPs, characterization methods of synthesized AuNPs, and discusses their physiochemical properties. This study also discusses recent breakthroughs and achievements in using green synthesized AuNPs in cancer treatment and different mechanisms of action, such as reactive oxygen species (ROS), mediated mitochondrial dysfunction and caspase activation, leading to apoptosis, etc., for their anticancer and cytotoxic effects. Understanding the mechanisms underlying AuNPs therapeutic efficacy will aid in developing personalized medicines and treatments for cancer as a potential cancer therapeutic strategy. View Full-Text
Keywords: gold nanoparticles; AuNPs; green synthesis; anticancer; plants; therapy gold nanoparticles; AuNPs; green synthesis; anticancer; plants; therapy
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MDPI and ACS Style

Bharadwaj, K.K.; Rabha, B.; Pati, S.; Sarkar, T.; Choudhury, B.K.; Barman, A.; Bhattacharjya, D.; Srivastava, A.; Baishya, D.; Edinur, H.A.; Abdul Kari, Z.; Mohd Noor, N.H. Green Synthesis of Gold Nanoparticles Using Plant Extracts as Beneficial Prospect for Cancer Theranostics. Molecules 2021, 26, 6389.

AMA Style

Bharadwaj KK, Rabha B, Pati S, Sarkar T, Choudhury BK, Barman A, Bhattacharjya D, Srivastava A, Baishya D, Edinur HA, Abdul Kari Z, Mohd Noor NH. Green Synthesis of Gold Nanoparticles Using Plant Extracts as Beneficial Prospect for Cancer Theranostics. Molecules. 2021; 26(21):6389.

Chicago/Turabian Style

Bharadwaj, Kaushik K., Bijuli Rabha, Siddhartha Pati, Tanmay Sarkar, Bhabesh K. Choudhury, Arpita Barman, Dorothy Bhattacharjya, Ankit Srivastava, Debabrat Baishya, Hisham A. Edinur, Zulhisyam Abdul Kari, and Noor H. Mohd Noor 2021. "Green Synthesis of Gold Nanoparticles Using Plant Extracts as Beneficial Prospect for Cancer Theranostics" Molecules 26, no. 21: 6389.

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