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Review

Prospects for More Efficient Multi-Photon Absorption Photosensitizers Exhibiting Both Reactive Oxygen Species Generation and Luminescence

1
Laboratoire PEIRENE, Université de Limoges, 123 Avenue Albert Thomas, 87060 Limoges, France
2
Advanced Materials Engineering and Modelling Group, Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspianskiego 27, 50-370 Wrocław, Poland
*
Author to whom correspondence should be addressed.
Academic Editors: M. Amparo F. Faustino, Carlos J. P. Monteiro and Catarina I. V. Ramos
Molecules 2021, 26(20), 6323; https://doi.org/10.3390/molecules26206323
Received: 20 September 2021 / Revised: 12 October 2021 / Accepted: 14 October 2021 / Published: 19 October 2021
(This article belongs to the Special Issue Photodynamic Therapy in Cancer Treatment 2021)
The use of two-photon absorption (TPA) for such applications as microscopy, imaging, and photodynamic therapy (PDT) offers several advantages over the usual one-photon excitation. This creates a need for photosensitizers that exhibit both strong two-photon absorption and the highly efficient generation of reactive oxygen species (ROS), as well as, ideally, bright luminescence. This review focuses on different strategies utilized to improve the TPA properties of various multi-photon absorbing species that have the required photophysical properties. Along with well-known families of photosensitizers, including porphyrins, we also describe other promising organic and organometallic structures and more complex systems involving organic and inorganic nanoparticles. We concentrate on the published studies that provide two-photon absorption cross-section values and the singlet oxygen (or other ROS) and luminescence quantum yields, which are crucial for potential use within PDT and diagnostics. We hope that this review will aid in the design and modification of novel TPA photosensitizers, which can help in exploiting the features of nonlinear absorption processes. View Full-Text
Keywords: photosensitizers; multi-photon absorption; two-photon absorption; reactive oxygen species; photodynamic therapy; nanoparticles; gold nanoparticles photosensitizers; multi-photon absorption; two-photon absorption; reactive oxygen species; photodynamic therapy; nanoparticles; gold nanoparticles
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MDPI and ACS Style

Robbins, E.; Leroy-Lhez, S.; Villandier, N.; Samoć, M.; Matczyszyn, K. Prospects for More Efficient Multi-Photon Absorption Photosensitizers Exhibiting Both Reactive Oxygen Species Generation and Luminescence. Molecules 2021, 26, 6323. https://doi.org/10.3390/molecules26206323

AMA Style

Robbins E, Leroy-Lhez S, Villandier N, Samoć M, Matczyszyn K. Prospects for More Efficient Multi-Photon Absorption Photosensitizers Exhibiting Both Reactive Oxygen Species Generation and Luminescence. Molecules. 2021; 26(20):6323. https://doi.org/10.3390/molecules26206323

Chicago/Turabian Style

Robbins, Emma, Stéphanie Leroy-Lhez, Nicolas Villandier, Marek Samoć, and Katarzyna Matczyszyn. 2021. "Prospects for More Efficient Multi-Photon Absorption Photosensitizers Exhibiting Both Reactive Oxygen Species Generation and Luminescence" Molecules 26, no. 20: 6323. https://doi.org/10.3390/molecules26206323

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