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Review

Natural Product-Based Hybrids as Potential Candidates for the Treatment of Cancer: Focus on Curcumin and Resveratrol

by
Nicola Micale
,
Maria Sofia Molonia
,
Andrea Citarella
,
Francesco Cimino
,
Antonina Saija
*,
Mariateresa Cristani
† and
Antonio Speciale
†
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres 31, I-98166 Messina, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Molecules 2021, 26(15), 4665; https://doi.org/10.3390/molecules26154665
Submission received: 11 June 2021 / Revised: 20 July 2021 / Accepted: 28 July 2021 / Published: 31 July 2021
(This article belongs to the Special Issue Hybrid Compounds Tailoring at the Nanoscale for Biomedical Applications)
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Abstract

One of the main current strategies for cancer treatment is represented by combination chemotherapy. More recently, this strategy shifted to the “hybrid strategy”, namely the designing of a new molecular entity containing two or more biologically active molecules and having superior features compared with the individual components. Moreover, the term “hybrid” has further extended to innovative drug delivery systems based on biocompatible nanomaterials and able to deliver one or more drugs to specific tissues or cells. At the same time, there is an increased interest in plant-derived polyphenols used as antitumoral drugs. The present review reports the most recent and intriguing research advances in the development of hybrids based on the polyphenols curcumin and resveratrol, which are known to act as multifunctional agents. We focused on two issues that are particularly interesting for the innovative chemical strategy involved in their development. On one hand, the pharmacophoric groups of these compounds have been used for the synthesis of new hybrid molecules. On the other hand, these polyphenols have been introduced into hybrid nanomaterials based on gold nanoparticles, which have many potential applications for both drug delivery and theranostics in chemotherapy.
Keywords: hybrid compounds; hybrid nanosystems; curcumin; resveratrol; anticancer activity hybrid compounds; hybrid nanosystems; curcumin; resveratrol; anticancer activity

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MDPI and ACS Style

Micale, N.; Molonia, M.S.; Citarella, A.; Cimino, F.; Saija, A.; Cristani, M.; Speciale, A. Natural Product-Based Hybrids as Potential Candidates for the Treatment of Cancer: Focus on Curcumin and Resveratrol. Molecules 2021, 26, 4665. https://doi.org/10.3390/molecules26154665

AMA Style

Micale N, Molonia MS, Citarella A, Cimino F, Saija A, Cristani M, Speciale A. Natural Product-Based Hybrids as Potential Candidates for the Treatment of Cancer: Focus on Curcumin and Resveratrol. Molecules. 2021; 26(15):4665. https://doi.org/10.3390/molecules26154665

Chicago/Turabian Style

Micale, Nicola, Maria Sofia Molonia, Andrea Citarella, Francesco Cimino, Antonina Saija, Mariateresa Cristani, and Antonio Speciale. 2021. "Natural Product-Based Hybrids as Potential Candidates for the Treatment of Cancer: Focus on Curcumin and Resveratrol" Molecules 26, no. 15: 4665. https://doi.org/10.3390/molecules26154665

APA Style

Micale, N., Molonia, M. S., Citarella, A., Cimino, F., Saija, A., Cristani, M., & Speciale, A. (2021). Natural Product-Based Hybrids as Potential Candidates for the Treatment of Cancer: Focus on Curcumin and Resveratrol. Molecules, 26(15), 4665. https://doi.org/10.3390/molecules26154665

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