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Review

Metabolic Engineering of Microbial Cell Factories for Biosynthesis of Flavonoids: A Review

by 1,†, 2,†, 1, 1 and 1,*
1
Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310058, China
2
Hubei Key Lab of Quality and Safety of Traditional Chinese Medicine & Health Food, Huangshi 435100, China
*
Author to whom correspondence should be addressed.
These authors are equally to this manuscript.
Academic Editor: Luciana Mosca
Molecules 2021, 26(15), 4522; https://doi.org/10.3390/molecules26154522
Received: 5 July 2021 / Revised: 15 July 2021 / Accepted: 25 July 2021 / Published: 27 July 2021
Flavonoids belong to a class of plant secondary metabolites that have a polyphenol structure. Flavonoids show extensive biological activity, such as antioxidative, anti-inflammatory, anti-mutagenic, anti-cancer, and antibacterial properties, so they are widely used in the food, pharmaceutical, and nutraceutical industries. However, traditional sources of flavonoids are no longer sufficient to meet current demands. In recent years, with the clarification of the biosynthetic pathway of flavonoids and the development of synthetic biology, it has become possible to use synthetic metabolic engineering methods with microorganisms as hosts to produce flavonoids. This article mainly reviews the biosynthetic pathways of flavonoids and the development of microbial expression systems for the production of flavonoids in order to provide a useful reference for further research on synthetic metabolic engineering of flavonoids. Meanwhile, the application of co-culture systems in the biosynthesis of flavonoids is emphasized in this review. View Full-Text
Keywords: flavonoids; metabolic engineering; co-culture system; biosynthesis; microbial cell factories flavonoids; metabolic engineering; co-culture system; biosynthesis; microbial cell factories
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MDPI and ACS Style

Lou, H.; Hu, L.; Lu, H.; Wei, T.; Chen, Q. Metabolic Engineering of Microbial Cell Factories for Biosynthesis of Flavonoids: A Review. Molecules 2021, 26, 4522. https://doi.org/10.3390/molecules26154522

AMA Style

Lou H, Hu L, Lu H, Wei T, Chen Q. Metabolic Engineering of Microbial Cell Factories for Biosynthesis of Flavonoids: A Review. Molecules. 2021; 26(15):4522. https://doi.org/10.3390/molecules26154522

Chicago/Turabian Style

Lou, Hanghang, Lifei Hu, Hongyun Lu, Tianyu Wei, and Qihe Chen. 2021. "Metabolic Engineering of Microbial Cell Factories for Biosynthesis of Flavonoids: A Review" Molecules 26, no. 15: 4522. https://doi.org/10.3390/molecules26154522

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