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Optimization of Ultrasound-Assisted Extraction of Phenolics from Sideritis raeseri Using Response Surface Methodology
Article

Optimization of MAE for the Separation of Nicotine and Phenolics from Tobacco Waste by Using the Response Surface Methodology Approach

1
Faculty of Food Technology Osijek, Josip Juraj Strossmayer University of Osijek, Franje Kuhača 18, 31000 Osijek, Croatia
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Public Institution RERA S.D. for Coordination and Development of Split-Dalmatia County, Domovinskog rata 2, 21000 Split, Croatia
3
Faculty of Technology, University of Novi Sad, Bulevar cara Lazara 1, 21000 Novi Sad, Serbia
*
Authors to whom correspondence should be addressed.
Academic Editor: Francisco J. Barba
Molecules 2021, 26(14), 4363; https://doi.org/10.3390/molecules26144363
Received: 3 July 2021 / Revised: 14 July 2021 / Accepted: 17 July 2021 / Published: 19 July 2021
(This article belongs to the Special Issue Ultrasound- and Microwave-Assisted Extraction of Bioactive Compounds)
This study intends to valorize by-products of the industrial processing of tobacco to obtain nicotine and phenolics as value-added compounds. Three influential parameters of the microwave-assisted extraction-MAE (temperature, treatment time, and solvent/solid ratio) were studied for the optimization of the extraction protocol for tobacco leaves and three types of waste—scrap, dust, and midrib, respectively. Nicotine was the dominant bioactive compound in all extracts, ranging from 1.512 to 5.480% in leaves, 1.886 to 3.709% in scrap, 2.628 to 4.840% dust, and 0.867 to 1.783% in midrib extracts. Five phenolic compounds were identified and quantified, predominated by chlorogenic acid and rutin. Additionally, total phenol content and antioxidant activity were determined using spectrophotometric assays. Optimization was performed in two aspects: to obtain a maximum extraction yield with minimum nicotine content and to obtain a maximum extraction yield with maximum nicotine content. These findings demonstrate that tobacco waste is a valuable source of bioactive compounds and MAE can be a promising alternative technique to obtain extracts rich in targeted bioactive compounds, especially nicotine. View Full-Text
Keywords: tobacco waste; microwave-assisted extraction; optimization; bioactive compounds tobacco waste; microwave-assisted extraction; optimization; bioactive compounds
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MDPI and ACS Style

Banožić, M.; Banjari, I.; Flanjak, I.; Paštar, M.; Vladić, J.; Jokić, S. Optimization of MAE for the Separation of Nicotine and Phenolics from Tobacco Waste by Using the Response Surface Methodology Approach. Molecules 2021, 26, 4363. https://doi.org/10.3390/molecules26144363

AMA Style

Banožić M, Banjari I, Flanjak I, Paštar M, Vladić J, Jokić S. Optimization of MAE for the Separation of Nicotine and Phenolics from Tobacco Waste by Using the Response Surface Methodology Approach. Molecules. 2021; 26(14):4363. https://doi.org/10.3390/molecules26144363

Chicago/Turabian Style

Banožić, Marija, Ines Banjari, Ivana Flanjak, Mate Paštar, Jelena Vladić, and Stela Jokić. 2021. "Optimization of MAE for the Separation of Nicotine and Phenolics from Tobacco Waste by Using the Response Surface Methodology Approach" Molecules 26, no. 14: 4363. https://doi.org/10.3390/molecules26144363

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