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Article

DNA-Templated Fluorescent Silver Nanoclusters Inhibit Bacterial Growth While Being Non-Toxic to Mammalian Cells

1
Nanoscale Science Program, Department of Chemistry, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
2
Department of Physics, University of Nebraska at Omaha, Omaha, NE 68182, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Jussara Amato and Ashok Kakkar
Molecules 2021, 26(13), 4045; https://doi.org/10.3390/molecules26134045
Received: 12 April 2021 / Revised: 21 June 2021 / Accepted: 29 June 2021 / Published: 1 July 2021
(This article belongs to the Special Issue Nucleic Acid Nanobiology for Drug Delivery and Immunotherapy)
Silver has a long history of antibacterial effectiveness. The combination of atomically precise metal nanoclusters with the field of nucleic acid nanotechnology has given rise to DNA-templated silver nanoclusters (DNA-AgNCs) which can be engineered with reproducible and unique fluorescent properties and antibacterial activity. Furthermore, cytosine-rich single-stranded DNA oligonucleotides designed to fold into hairpin structures improve the stability of AgNCs and additionally modulate their antibacterial properties and the quality of observed fluorescent signals. In this work, we characterize the sequence-specific fluorescence and composition of four representative DNA-AgNCs, compare their corresponding antibacterial effectiveness at different pH, and assess cytotoxicity to several mammalian cell lines. View Full-Text
Keywords: DNA; silver; AgNC; nanocluster; antibacterial; fluorescence DNA; silver; AgNC; nanocluster; antibacterial; fluorescence
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MDPI and ACS Style

Rolband, L.; Yourston, L.; Chandler, M.; Beasock, D.; Danai, L.; Kozlov, S.; Marshall, N.; Shevchenko, O.; Krasnoslobodtsev, A.V.; Afonin, K.A. DNA-Templated Fluorescent Silver Nanoclusters Inhibit Bacterial Growth While Being Non-Toxic to Mammalian Cells. Molecules 2021, 26, 4045. https://doi.org/10.3390/molecules26134045

AMA Style

Rolband L, Yourston L, Chandler M, Beasock D, Danai L, Kozlov S, Marshall N, Shevchenko O, Krasnoslobodtsev AV, Afonin KA. DNA-Templated Fluorescent Silver Nanoclusters Inhibit Bacterial Growth While Being Non-Toxic to Mammalian Cells. Molecules. 2021; 26(13):4045. https://doi.org/10.3390/molecules26134045

Chicago/Turabian Style

Rolband, Lewis, Liam Yourston, Morgan Chandler, Damian Beasock, Leyla Danai, Seraphim Kozlov, Nolan Marshall, Oleg Shevchenko, Alexey V. Krasnoslobodtsev, and Kirill A. Afonin. 2021. "DNA-Templated Fluorescent Silver Nanoclusters Inhibit Bacterial Growth While Being Non-Toxic to Mammalian Cells" Molecules 26, no. 13: 4045. https://doi.org/10.3390/molecules26134045

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