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Review

Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review

1
Centre of Biodiversity Conservation & Management, G.B.Pant National Institute of Himalayan Environment, Almora 263643, Uttarakhand, India
2
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, Punjab, India
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Department of Endocrinology, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei 230037, China
4
Department of Pharmacy, Huadu District People’s Hospital, Southern Medical University, Guangzhou 510800, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Assunta Pandolfi
Molecules 2021, 26(13), 4036; https://doi.org/10.3390/molecules26134036
Received: 29 March 2021 / Revised: 27 June 2021 / Accepted: 28 June 2021 / Published: 1 July 2021
(This article belongs to the Special Issue Natural Products for Cardiovascular Disease)
Curcumin, a natural polyphenolic compound present in Curcuma longa L. rhizomes, shows potent antioxidant, anti-inflammatory, anti-cancer, and anti-atherosclerotic properties. Atherosclerosis is a comprehensive term for a series of degenerative and hyperplasic lesions such as thickening or sclerosis in large- and medium-sized arteries, causing decreased vascular-wall elasticity and lumen diameter. Atherosclerotic cerebro-cardiovascular disease has become a major concern for human health in recent years due to its clinical sequalae of strokes and heart attacks. Curcumin concoction treatment modulates several important signaling pathways related to cellular migration, proliferation, cholesterol homeostasis, inflammation, and gene transcription, among other relevant actions. Here, we provide an overview of curcumin in atherosclerosis prevention and disclose the underlying mechanisms of action of its anti-atherosclerotic effects. View Full-Text
Keywords: curcumin; atherosclerosis; pharmacology; therapeutics curcumin; atherosclerosis; pharmacology; therapeutics
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MDPI and ACS Style

Singh, L.; Sharma, S.; Xu, S.; Tewari, D.; Fang, J. Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review. Molecules 2021, 26, 4036. https://doi.org/10.3390/molecules26134036

AMA Style

Singh L, Sharma S, Xu S, Tewari D, Fang J. Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review. Molecules. 2021; 26(13):4036. https://doi.org/10.3390/molecules26134036

Chicago/Turabian Style

Singh, Laxman, Shikha Sharma, Suowen Xu, Devesh Tewari, and Jian Fang. 2021. "Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review" Molecules 26, no. 13: 4036. https://doi.org/10.3390/molecules26134036

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