Next Article in Journal
Synthesis and Antiviral Evaluation of Nucleoside Analogues Bearing One Pyrimidine Moiety and Two D-Ribofuranosyl Residues
Previous Article in Journal
K-Nearest Neighbor and Random Forest-Based Prediction of Putative Tyrosinase Inhibitory Peptides of Abalone Haliotis diversicolor
 
 
Article

Concise Synthesis of Both Enantiomers of Pilocarpine

1
Department of Organic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes Str. 2, D-06120 Halle (Saale), Germany
2
Department of Inorganic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes Str. 2, D-06120 Halle (Saale), Germany
3
Medical and Life Science Faculty, Institute of Precision Medicine, Furtwangen University, Jakob-Kienzle, Str. 17, D-78054 Villingen–Schwenningen, Germany
4
Chair of Oman’s Medicinal Plants and Marine Natural Products, University of Nizwa, P.O. Box 33, PC 616 Nizwa, Oman
*
Author to whom correspondence should be addressed.
Academic Editor: John C. D’Auria
Molecules 2021, 26(12), 3676; https://doi.org/10.3390/molecules26123676
Received: 28 May 2021 / Revised: 13 June 2021 / Accepted: 14 June 2021 / Published: 16 June 2021
(This article belongs to the Section Natural Products Chemistry)
Furan-2-carboxylic acid was used as a starting material for the synthesis of dehydro-homopilopic acid. Esterification, hydrogenation and enzymatic hydrolysis followed by the reduction of Weinreb amides and a single-step attachment of a 1-methyl-imidazole residue allowed for the concise synthesis of both enantiomers of pilocarpine. View Full-Text
Keywords: pilocarpine; enzymatic resolution; alkaloids pilocarpine; enzymatic resolution; alkaloids
Show Figures

Graphical abstract

MDPI and ACS Style

Schmidt, T.; Heise, N.; Merzweiler, K.; Deigner, H.-P.; Al-Harrasi, A.; Csuk, R. Concise Synthesis of Both Enantiomers of Pilocarpine. Molecules 2021, 26, 3676. https://doi.org/10.3390/molecules26123676

AMA Style

Schmidt T, Heise N, Merzweiler K, Deigner H-P, Al-Harrasi A, Csuk R. Concise Synthesis of Both Enantiomers of Pilocarpine. Molecules. 2021; 26(12):3676. https://doi.org/10.3390/molecules26123676

Chicago/Turabian Style

Schmidt, Theresa, Niels Heise, Kurt Merzweiler, Hans-Peter Deigner, Ahmed Al-Harrasi, and René Csuk. 2021. "Concise Synthesis of Both Enantiomers of Pilocarpine" Molecules 26, no. 12: 3676. https://doi.org/10.3390/molecules26123676

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop