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Article

Development of a Promising Method for Producing Oligomeric Mixture of Branched Alkylene Guanidines to Improve Substance Quality and Evaluate Their Antiviral Activity against SARS-CoV-2

by
Denis O. Shatalov
1,
Stanislav A. Kedik
1,
Ivan S. Ivanov
1,
Anna V. Aydakova
1,2,
Diana A. Akhmedova
1,2,*,
Dmitrii S. Minenkov
3,
Sergei V. Beliakov
1,
Alexander Herbst
4,
Lasse Greiner
5,
Liubov I. Kozlovskaya
6,7 and
Viktor P. Volok
6
1
Institute of Fine Chemical Technologies Named after Lomonosov, MIREA—Russian Technological University, 119571 Moscow, Russia
2
Institute of Pharmaceutical Technology, 119571 Moscow, Russia
3
Ishlinsky Institute for Problems in Mechanics RAS, 119526 Moscow, Russia
4
Wingflow AG, Gaensaker 5, 5070 Frick, Switzerland
5
Mannheim University of Applied Sciences, 68163 Mannheim, Germany
6
FSBSI “Chumakov FSC R&D IBP RAS”, 108819 Moscow, Russia
7
Institute of Translational Medicine and Biotechnology, Sechenov Moscow State Medical University, 117418 Moscow, Russia
*
Author to whom correspondence should be addressed.
Molecules 2021, 26(11), 3472; https://doi.org/10.3390/molecules26113472
Submission received: 14 April 2021 / Revised: 19 May 2021 / Accepted: 2 June 2021 / Published: 7 June 2021
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Abstract

This paper reports the synthesis of branched alkylene guanidines using microfluidic technologies. We describe the preparation of guanidine derivatives at lower temperatures, and with significantly less time than that required in the previously applicable method. Furthermore, the use of microfluidics allows the attainment of high-purity products with a low residual monomer content, which can expand the range of applications of this class of compounds. For all the samples obtained, the molecular-weight characteristics are calculated, based on which the optimal condensation conditions are established. Additionally, in this work, the antiviral activity of the alkylene guanidine salt against the SARS-CoV-2 virus is confirmed.
Keywords: antiseptic; microfluidics; microreactor; polycondensation; antimicrobial resistance; antiviral activity antiseptic; microfluidics; microreactor; polycondensation; antimicrobial resistance; antiviral activity

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MDPI and ACS Style

Shatalov, D.O.; Kedik, S.A.; Ivanov, I.S.; Aydakova, A.V.; Akhmedova, D.A.; Minenkov, D.S.; Beliakov, S.V.; Herbst, A.; Greiner, L.; Kozlovskaya, L.I.; et al. Development of a Promising Method for Producing Oligomeric Mixture of Branched Alkylene Guanidines to Improve Substance Quality and Evaluate Their Antiviral Activity against SARS-CoV-2. Molecules 2021, 26, 3472. https://doi.org/10.3390/molecules26113472

AMA Style

Shatalov DO, Kedik SA, Ivanov IS, Aydakova AV, Akhmedova DA, Minenkov DS, Beliakov SV, Herbst A, Greiner L, Kozlovskaya LI, et al. Development of a Promising Method for Producing Oligomeric Mixture of Branched Alkylene Guanidines to Improve Substance Quality and Evaluate Their Antiviral Activity against SARS-CoV-2. Molecules. 2021; 26(11):3472. https://doi.org/10.3390/molecules26113472

Chicago/Turabian Style

Shatalov, Denis O., Stanislav A. Kedik, Ivan S. Ivanov, Anna V. Aydakova, Diana A. Akhmedova, Dmitrii S. Minenkov, Sergei V. Beliakov, Alexander Herbst, Lasse Greiner, Liubov I. Kozlovskaya, and et al. 2021. "Development of a Promising Method for Producing Oligomeric Mixture of Branched Alkylene Guanidines to Improve Substance Quality and Evaluate Their Antiviral Activity against SARS-CoV-2" Molecules 26, no. 11: 3472. https://doi.org/10.3390/molecules26113472

APA Style

Shatalov, D. O., Kedik, S. A., Ivanov, I. S., Aydakova, A. V., Akhmedova, D. A., Minenkov, D. S., Beliakov, S. V., Herbst, A., Greiner, L., Kozlovskaya, L. I., & Volok, V. P. (2021). Development of a Promising Method for Producing Oligomeric Mixture of Branched Alkylene Guanidines to Improve Substance Quality and Evaluate Their Antiviral Activity against SARS-CoV-2. Molecules, 26(11), 3472. https://doi.org/10.3390/molecules26113472

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