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Article

Adsorptive Cathodic Stripping Voltammetry for Quantification of Alprazolam

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Division of Health and Applied Sciences, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand
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Forensic Innovation Center, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand
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Center of Excellence for Trace Analysis and Biosensor, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand
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Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, HatYai, Songkhla 90112, Thailand
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Satun Provincial Police Forensic Science, Police Forensic Science Center 9, Office of Police Forensic Science, Royal Thai Police, Mueangsatun, Satun 91000, Thailand
*
Author to whom correspondence should be addressed.
Academic Editor: Antonella Curulli
Molecules 2021, 26(10), 2958; https://doi.org/10.3390/molecules26102958
Received: 12 April 2021 / Revised: 4 May 2021 / Accepted: 8 May 2021 / Published: 16 May 2021
A simple and highly sensitive electrochemical sensor was developed for adsorptive cathodic stripping voltammetry of alprazolam. Based on an electrochemically pretreated glassy carbon electrode, the sensor demonstrated good adsorption and electrochemical reduction of alprazolam. The morphology of the glassy carbon electrode and the electrochemically pretreated glassy carbon electrode were characterized by scanning electron microscopy/energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, cyclic voltammetry, and electrochemical impedance spectroscopy. The electrochemical behaviors of alprazolam were determined by cyclic voltammetry, and the analytical measurements were studied by adsorptive cathodic stripping voltammetry. Optimized operational conditions included the concentration and deposition time of sulfuric acid in the electrochemical pretreatment, preconcentration potential, and preconcentration time. Under optimal conditions, the developed alprazolam sensor displayed a quantification limit of 0.1 mg L−1, a detection limit of 0.03 mg L−1, a sensitivity of 67 µA mg−1 L cm−2 and two linear ranges: 0.1 to 4 and 4 to 20 mg L−1. Sensor selectivity was excellent, and repeatability (%RSD < 4.24%) and recovery (82.0 ± 0.2 to 109.0 ± 0.3%) were good. The results of determining alprazolam in beverages with the developed system were in good agreement with results from the gas chromatography–mass spectrometric method. View Full-Text
Keywords: electrochemical pretreatment; sensor; alprazolam; adsorptive cathodic stripping voltammetry electrochemical pretreatment; sensor; alprazolam; adsorptive cathodic stripping voltammetry
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MDPI and ACS Style

Boonmee, W.; Samoson, K.; Yodrak, J.; Thiagchanya, A.; Phonchai, A.; Limbut, W. Adsorptive Cathodic Stripping Voltammetry for Quantification of Alprazolam. Molecules 2021, 26, 2958. https://doi.org/10.3390/molecules26102958

AMA Style

Boonmee W, Samoson K, Yodrak J, Thiagchanya A, Phonchai A, Limbut W. Adsorptive Cathodic Stripping Voltammetry for Quantification of Alprazolam. Molecules. 2021; 26(10):2958. https://doi.org/10.3390/molecules26102958

Chicago/Turabian Style

Boonmee, Waree, Kritsada Samoson, Janjira Yodrak, Adul Thiagchanya, Apichai Phonchai, and Warakorn Limbut. 2021. "Adsorptive Cathodic Stripping Voltammetry for Quantification of Alprazolam" Molecules 26, no. 10: 2958. https://doi.org/10.3390/molecules26102958

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