Next Article in Journal
Substitution or Dilution? Assessing Pre-Fermentative Water Implementation to Produce Lower Alcohol Shiraz Wines
Previous Article in Journal
Do Aspirin and Flavonoids Prevent Cancer through a Common Mechanism Involving Hydroxybenzoic Acids?—The Metabolite Hypothesis
Article

Formulation, Characterization and Biological Activity Screening of Sodium Alginate-Gum Arabic Nanoparticles Loaded with Curcumin

1
Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia, Kuantan 25200, Malaysia
2
Department of Chemical and Environmental Engineering, Faculty of Engineering, University Putra Malaysia, UPM, Serdang 43400, Malaysia
3
Department of Pharmaceutical Engineering, Faculty of Chemical and Process Engineering Technology, University Malaysia Pahang, Gambang 26300, Malaysia
4
Centre of Excellence for Advanced Research in Fluid Flow (CARIFF), University Malaysian Pahang, Gambang 26300, Malaysia
5
Department of Oral and Maxillofacial Surgery, Collage of Dentistry, University of Anbar, Ramadi, Iraq
6
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, UPM, Serdang 43300, Malaysia
7
Department of Nutrition Sciences, Faculty of Allied Health Sciences, International Islamic University Malaysia, Kuantan 25200, Malaysia
8
Department of Biomedical sciences, College of Health sciences, QU Health, Qatar University, Doha, Qatar
*
Authors to whom correspondence should be addressed.
Molecules 2020, 25(9), 2244; https://doi.org/10.3390/molecules25092244
Received: 4 March 2020 / Revised: 16 April 2020 / Accepted: 21 April 2020 / Published: 10 May 2020
The approach of drug delivery systems emphasizes the use of nanoparticles as a vehicle, offering the optional property of delivering drugs as a single dose rather than in multiple doses. The current study aims to improve antioxidant and drug release properties of curcumin loaded gum Arabic-sodium alginate nanoparticles (Cur/ALG-GANPs). The Cur/ALG-GANPs were prepared using the ionotropic gelation technique and further subjected to physico-chemical characterization using attenuated total reflectance–Fourier transform infrared (ATR-FTIR), X-ray diffractometry (XRD), differential scanning calorimetry (DSC), size distribution, and transmission electron microscopy (TEM). The size of Cur/ALG-GANPs ranged between 10 ± 0.3 nm and 190 ± 0.1 nm and the zeta potential was –15 ± 0.2 mV. The antioxidant study of Cur/ALG-GANPs exhibited effective radical scavenging capacity for 1,1-diphenyl-2-picrylhydrazyl (DPPH) at concentrations that ranged between 30 and 500µg/mL. Cytotoxicity was performed using MTT assay to measure their potential in inhibiting the cell growth and the result demonstrated a significant anticancer activity of Cur/ALG-GANPs against human liver cancer cells (HepG2) than in colon cancer (HT29), lung cancer (A549) and breast cancer (MCF7) cells. Thus, this study indicates that Cur/ALG-GANPs have promising anticancer properties that might aid in future cancer therapy. View Full-Text
Keywords: curcumin; gum Arabic; sodium alginate; nanoparticles; cytotoxicity curcumin; gum Arabic; sodium alginate; nanoparticles; cytotoxicity
Show Figures

Figure 1

MDPI and ACS Style

Hassani, A.; Mahmood, S.; Enezei, H.H.; Hussain, S.A.; Hamad, H.A.; Aldoghachi, A.F.; Hagar, A.; Doolaanea, A.A.; Ibrahim, W.N. Formulation, Characterization and Biological Activity Screening of Sodium Alginate-Gum Arabic Nanoparticles Loaded with Curcumin. Molecules 2020, 25, 2244. https://doi.org/10.3390/molecules25092244

AMA Style

Hassani A, Mahmood S, Enezei HH, Hussain SA, Hamad HA, Aldoghachi AF, Hagar A, Doolaanea AA, Ibrahim WN. Formulation, Characterization and Biological Activity Screening of Sodium Alginate-Gum Arabic Nanoparticles Loaded with Curcumin. Molecules. 2020; 25(9):2244. https://doi.org/10.3390/molecules25092244

Chicago/Turabian Style

Hassani, Abdelkader, Syed Mahmood, Hamid H. Enezei, Siti A. Hussain, Hamad A. Hamad, Ahmed F. Aldoghachi, Abdullah Hagar, Abd A. Doolaanea, and Wisam N. Ibrahim 2020. "Formulation, Characterization and Biological Activity Screening of Sodium Alginate-Gum Arabic Nanoparticles Loaded with Curcumin" Molecules 25, no. 9: 2244. https://doi.org/10.3390/molecules25092244

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop