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Review

Nutraceuticals and Metastasis Development

1
University of Rijeka, Department of Biotechnology, Radmile Matejčić 2, HR-51000 Rijeka, Croatia
2
Juraj Dobrila University of Pula, Faculty of Medicine, HR-52100 Pula, Croatia
*
Author to whom correspondence should be addressed.
Molecules 2020, 25(9), 2222; https://doi.org/10.3390/molecules25092222
Received: 5 April 2020 / Revised: 28 April 2020 / Accepted: 5 May 2020 / Published: 8 May 2020
(This article belongs to the Special Issue Translational Approach to Antitumor Drugs)
Nutrigenomics is a discipline that studies the effects of various dietary components on gene expression and molecular mechanisms via “omics” technologies. Many studies are focused on revealing the pathways of the anticancer properties of various nutraceuticals. However, it has been shown that metastasis, a multifactorial disease that develops from primary tumors in cascades, is responsible for almost 90% of cancer deaths. Regrettably, the effects of consumption of different nutraceuticals on metastasis development have not yet been sufficiently explored. A few studies on the subject have revealed the promotional effects of some nutraceuticals on metastasis development. Additionally, it has been shown that certain compounds can have beneficial effects on reduction of the primary tumor, but afterwards promote the spread of metastases. Therefore, in this review we discuss results published in the past five years focused on the effects of different nutraceuticals on metastasis development. View Full-Text
Keywords: nutrigenomics; metastases; small molecules; antioxidants; high-fat diet; phytoestrogens nutrigenomics; metastases; small molecules; antioxidants; high-fat diet; phytoestrogens
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MDPI and ACS Style

Saftić Martinović, L.; Peršurić, Ž.; Pavelić, K. Nutraceuticals and Metastasis Development. Molecules 2020, 25, 2222. https://doi.org/10.3390/molecules25092222

AMA Style

Saftić Martinović L, Peršurić Ž, Pavelić K. Nutraceuticals and Metastasis Development. Molecules. 2020; 25(9):2222. https://doi.org/10.3390/molecules25092222

Chicago/Turabian Style

Saftić Martinović, Lara, Željka Peršurić, and Krešimir Pavelić. 2020. "Nutraceuticals and Metastasis Development" Molecules 25, no. 9: 2222. https://doi.org/10.3390/molecules25092222

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