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Open AccessArticle

Innovative Bio-Based Organic UV-A and Blue Light Filters from Meldrum’s Acid

1
URD Agro-Biotechnologies Industrielles (ABI), CEBB, AgroParisTech, 51110 Pomacle, France
2
IRCM, Inserm, Univ Montpellier, ICM, 208 Avenue des Apothicaires, CEDEX 5, 34298 Montpellier, France
*
Author to whom correspondence should be addressed.
Academic Editors: Ana Estévez-Braun and Ángel Amesty
Molecules 2020, 25(9), 2178; https://doi.org/10.3390/molecules25092178
Received: 15 April 2020 / Revised: 2 May 2020 / Accepted: 4 May 2020 / Published: 6 May 2020
(This article belongs to the Special Issue Strategies toward Bioactive Natural Product Like-Compounds)
Faced with the ban of some organic UV filters such as octinoxate or avobenzone, especially in Hawaii, it became essential to offer new alternatives that are both renewable and safe for humans and the environment. In this context, a class of bio-based molecules displaying interesting UV filter properties and great (photo)stability has been developed from Meldrum’s acid and bio-based and synthetic p-hydroxycinnamic acids, furans and pyrroles. Moreover, p-hydroxycinnamic acid-based Meldrum’s derivatives possess valuable secondary activities sought by the cosmetic industry such as antioxidant and anti-tyrosinase properties. The evaluation of the properties of mixture of judiciously chosen Meldrum’s acid derivatives highlighted the possibility to modulate secondary activity while maintaining excellent UV protection. Meldrum’s acid derivatives are not only competitive when benchmarked against organic filters currently on the market (i.e., avobenzone), but they also do not exhibit any endocrine disruption activity. View Full-Text
Keywords: photoprotection; bio-based chemicals; Meldrum’s acid; UV-A; blue light; organic UV filters photoprotection; bio-based chemicals; Meldrum’s acid; UV-A; blue light; organic UV filters
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MDPI and ACS Style

Peyrot, C.; Mention, M.M.; Brunissen, F.; Balaguer, P.; Allais, F. Innovative Bio-Based Organic UV-A and Blue Light Filters from Meldrum’s Acid. Molecules 2020, 25, 2178.

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