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In Vitro Anti-Leishmanial Effect of Metallic Meso-Substituted Porphyrin Derivatives against Leishmania braziliensis and Leishmania panamensis Promastigotes Properties

1
Grupo de Fotoquímica y Fotobiología, Universidad del Atlántico, Puerto Colombia 810007, Colombia
2
Grupo de Investigación UNIMOL, Universidad de Cartagena, Cartagena 130001, Colombia
3
Grupo de Investigación CODEIM, Universidad Industrial de Santander, Bucaramanga 680002, Colombia
*
Author to whom correspondence should be addressed.
Academic Editors: M. Salomé Rodríguez-Morgade and Soji Shimizu
Molecules 2020, 25(8), 1887; https://doi.org/10.3390/molecules25081887
Received: 23 March 2020 / Revised: 11 April 2020 / Accepted: 17 April 2020 / Published: 19 April 2020
(This article belongs to the Special Issue Phthalocyanines and Porphyrins)
In this study, a family of porphyrins based on 5,10,15,20-Tetrakis(4-ethylphenyl)porphyrin (1, Ph) and six metallo-derivatives (Zn2+(2, Ph-Zn), Sn4+(3, Ph-Sn), Mn2+ (4, Ph-Mn), Ni2+ (5, Ph-Ni), Al3+ (6, Ph-Al), and V3+ (7, Ph-V)) were tested as photosensitizers for photodynamic therapy against Leishmania braziliensis and panamensis. The singlet oxygen quantum yield value (ΦΔ) for (17) was measured using 1,3-diphenylisobenzofuran (DPBF) as a singlet oxygen trapping agent and 5,10,15,20-(tetraphenyl)-porphyrin (H2TPP) as a reference standard; besides, parasite viability was estimated by the MTT assay. After metal insertion into the porphyrin core, the ΦΔ increased from 0.76–0.90 and cell viability changed considerably. The ΦΔ and metal type changed the cytotoxic activity. Finally, (2) showed both the highest ΦΔ (0.90) and the best photodynamic activity against the parasites studied (IC50 of 1.2 μM). View Full-Text
Keywords: porphyrin; metalloporphyrins; photodynamic therapy; Leishmania braziliensis; Leishmania panamensis; singlet oxygen porphyrin; metalloporphyrins; photodynamic therapy; Leishmania braziliensis; Leishmania panamensis; singlet oxygen
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Espitia-Almeida, F.; Díaz-Uribe, C.; Vallejo, W.; Gómez-Camargo, D.; Romero Bohórquez, A.R. In Vitro Anti-Leishmanial Effect of Metallic Meso-Substituted Porphyrin Derivatives against Leishmania braziliensis and Leishmania panamensis Promastigotes Properties. Molecules 2020, 25, 1887.

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