Next Article in Journal
Antioxidative Activity of 1,3,5-Triazine Analogues Incorporating Aminobenzene Sulfonamide, Aminoalcohol/Phenol, Piperazine, Chalcone, or Stilbene Motifs
Next Article in Special Issue
Exploring the Scope of Tandem Palladium and Isothiourea Relay Catalysis for the Synthesis of α-Amino Acid Derivatives
Previous Article in Journal
Synthesis, Antiproliferative Activity and Molecular Docking Studies of Novel Doubly Modified Colchicine Amides and Sulfonamides as Anticancer Agents
Previous Article in Special Issue
Regioselective Monobromination of Phenols with KBr and ZnAl–BrO3–Layered Double Hydroxides
Open AccessArticle

Copper-Promoted One-Pot Approach: Synthesis of Benzimidazoles

Department of Chemistry, Acharya Nagarjuna University, Guntur, Andhar Pradesh 522510, India
Department of Chemistry, Sir C. R. Reddy College, PG Courses, Eluru, Andhra Pradesh 534002, India
Department of Chemistry, GITAM Deemed to Be University, Bengaluru Campus, Karnataka 562163, India
Department of Chemistry, College of Science, King Saud University, P.O. 2455, Riyadh 11451, Saudi Arabia
Authors to whom correspondence should be addressed.
Academic Editor: Narciso M. Garrido
Molecules 2020, 25(8), 1788;
Received: 11 March 2020 / Revised: 6 April 2020 / Accepted: 9 April 2020 / Published: 14 April 2020
(This article belongs to the Special Issue New Synthetic Methods for Organic Compounds)
A facile, one-pot, and proficient method was developed for the production of various 2-arylaminobenzimidazoles. This methodology is based for the first time on a copper catalyst promoted domino C–N cross-coupling reaction for the generation of 2-arylaminobenzimidazoles. Mechanistic investigations revealed that the synthetic pathway involves a copper-based desulphurization/nucleophilic substitution and a subsequent domino intra and intermolecular C–N cross-coupling reactions. Some of the issues typically encountered during the synthesis of 2-arylaminobezimidazoles, including the use of expensive catalytic systems and the low reactivity of bromo precursors, were addressed using this newly developed copper-catalyzed method. The reaction procedure is simple, generally with excellent substrate tolerance, and provides good to high yields of the desired products. View Full-Text
Keywords: copper catalyst; desulfurization; domino C–Ncross-coupling; 2-aminoaryl benzimidazole; homogeneous catalysis copper catalyst; desulfurization; domino C–Ncross-coupling; 2-aminoaryl benzimidazole; homogeneous catalysis
Show Figures

Figure 1

MDPI and ACS Style

Boddapati, S.N.M.; Tamminana, R.; Gollapudi, R.K.; Nurbasha, S.; Assal, M.E.; Alduhaish, O.; Siddiqui, M.R.H.; Bollikolla, H.B.; Adil, S.F. Copper-Promoted One-Pot Approach: Synthesis of Benzimidazoles. Molecules 2020, 25, 1788.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop