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Open AccessArticle

Copper-Promoted One-Pot Approach: Synthesis of Benzimidazoles

1
Department of Chemistry, Acharya Nagarjuna University, Guntur, Andhar Pradesh 522510, India
2
Department of Chemistry, Sir C. R. Reddy College, PG Courses, Eluru, Andhra Pradesh 534002, India
3
Department of Chemistry, GITAM Deemed to Be University, Bengaluru Campus, Karnataka 562163, India
4
Department of Chemistry, College of Science, King Saud University, P.O. 2455, Riyadh 11451, Saudi Arabia
*
Authors to whom correspondence should be addressed.
Academic Editor: Narciso M. Garrido
Molecules 2020, 25(8), 1788; https://doi.org/10.3390/molecules25081788
Received: 11 March 2020 / Revised: 6 April 2020 / Accepted: 9 April 2020 / Published: 14 April 2020
(This article belongs to the Special Issue New Synthetic Methods for Organic Compounds)
A facile, one-pot, and proficient method was developed for the production of various 2-arylaminobenzimidazoles. This methodology is based for the first time on a copper catalyst promoted domino C–N cross-coupling reaction for the generation of 2-arylaminobenzimidazoles. Mechanistic investigations revealed that the synthetic pathway involves a copper-based desulphurization/nucleophilic substitution and a subsequent domino intra and intermolecular C–N cross-coupling reactions. Some of the issues typically encountered during the synthesis of 2-arylaminobezimidazoles, including the use of expensive catalytic systems and the low reactivity of bromo precursors, were addressed using this newly developed copper-catalyzed method. The reaction procedure is simple, generally with excellent substrate tolerance, and provides good to high yields of the desired products. View Full-Text
Keywords: copper catalyst; desulfurization; domino C–Ncross-coupling; 2-aminoaryl benzimidazole; homogeneous catalysis copper catalyst; desulfurization; domino C–Ncross-coupling; 2-aminoaryl benzimidazole; homogeneous catalysis
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Boddapati, S.N.M.; Tamminana, R.; Gollapudi, R.K.; Nurbasha, S.; Assal, M.E.; Alduhaish, O.; Siddiqui, M.R.H.; Bollikolla, H.B.; Adil, S.F. Copper-Promoted One-Pot Approach: Synthesis of Benzimidazoles. Molecules 2020, 25, 1788.

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