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Open AccessArticle

A Higher Frequency Administration of the Nontoxic Cycloartane-Type Triterpene Argentatin A Improved Its Anti-Tumor Activity

1
Departamento de Productos Naturales. Instituto de Química, Universidad Nacional Autónoma de México, Mexico City, Circuito Exterior s/n, Ciudad Universitaria, Mexico City 04510, Mexico
2
Unidad de Bioquímica. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Sección XVI, Mexico City 14000, Mexico
3
Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Circuito Mario de la Cueva s/n, Ciudad Universitaria, C.P. Mexico City 04510, Mexico
4
Departamento de Médicina Genómica y Tóxicología Ambiental & Programa Institucional de Cáncer de Mama, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Circuito Deportivo s/n, Ciudad Universitaria, Mexico City 04510, Mexico
*
Author to whom correspondence should be addressed.
Academic Editors: Simona Collina and Mariarosaria Miloso
Molecules 2020, 25(8), 1780; https://doi.org/10.3390/molecules25081780
Received: 17 March 2020 / Revised: 2 April 2020 / Accepted: 3 April 2020 / Published: 14 April 2020
(This article belongs to the Special Issue Recent Advances in Anticancer Drugs II)
Parthenium argentatum (Gray), commonly known as guayule, has been used to obtain natural rubber since the beginning of the 20th century. Additionally, the so called “resin” is a waste product derived from the industrial process. The cycloartane-type triterpene Argentatin A (AA) is one of the main constituents of the industrial waste resin. In this study we evaluated the AA anticancer activity both in vitro and in vivo in the HCT116 colon cancer cells. The apoptosis promotion of AA was assessed by the annexin V/propidium iodide (PI) assay. The senescence was evaluated for SA-β-galactosidase, and PCNA was used as a marker of proliferation. Its antitumor activity was evaluated using a xenograft mouse model. The results indicated that AA-induced apoptosis in HCT-116 cells and was positively stained for SA-β-galactosidase. In the xenografted mice test, the administration of AA at the dose of 250 mg/kg three times a week for 21 days reduced tumor growth by 78.1%. A comparable tumor reduction was achieved with cisplatin at the dose of 2 mg/kg administered three times a week for 21 days. However, nude mice treated with AA did not lose weight, as they did remarkably when treated with cisplatin. Furthermore, the animals treated with AA showed similar blood profiles as the healthy control group. These data indicate the low toxicity of AA compared to that shown by cisplatin. View Full-Text
Keywords: Argentatin A; colon cancer; cell senescence; xenografts; antiproliferative; apoptosis; antitumor; PCNA Argentatin A; colon cancer; cell senescence; xenografts; antiproliferative; apoptosis; antitumor; PCNA
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MDPI and ACS Style

Tavarez-Santamaría, Z.; Jacobo-Herrera, N.J.; Rocha-Zavaleta, L.; Zentella-Dehesa, A.; Couder-García, B.C.; Martínez-Vázquez, M. A Higher Frequency Administration of the Nontoxic Cycloartane-Type Triterpene Argentatin A Improved Its Anti-Tumor Activity. Molecules 2020, 25, 1780.

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