Next Article in Journal
New Insights into 4-Anilinoquinazolines as Inhibitors of Cardiac Troponin I–Interacting Kinase (TNNi3K)
Next Article in Special Issue
Polysaccharide κ-Carrageenan as Doping Agent in Conductive Coatings for Electrochemical Controlled Release of Dexamethasone at Therapeutic Doses
Previous Article in Journal
Determining the Cytotoxicity of Oxidized Lipids in Cultured Caco-2 Cells Using Bioimaging Techniques
Previous Article in Special Issue
Pre-Clinical Investigation of Keratose as an Excipient of Drug Coated Balloons
Open AccessArticle

Aerogels from Cellulose Phosphates of Low Degree of Substitution: A TBAF·H2O/DMSO Based Approach

1
University of Natural Resources and Life Sciences, Vienna (BOKU), Institute for Chemistry of Renewable Resources, Konrad-Lorenz-Straße 24, A-3430 Tulln, Austria
2
Vienna University of Technology, Institute of Materials Chemistry, Getreidemarkt 9/165, A-1060 Vienna, Austria
3
Université Clermont Auvergne, CNRS, SIGMA Clermont, ICCF, F-63000 Clermont-Ferrand, France
4
University of Natural Resources and Life Sciences, Vienna (BOKU), Institute for Chemical and Energy Engineering, Muthgasse 107, A-1190 Vienna, Austria
5
Johan Gadolin Process Chemistry Centre, Åbo Akademi University, Porthansgatan 3, FI-20500 Åbo/Turku, Finland
6
University Aveiro, Department of Chemistry and CICECO Aveiro Institute of Materials, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal
*
Author to whom correspondence should be addressed.
Academic Editors: Carlos A. García-González, Pasquale Del Gaudio and Ricardo Starbird
Molecules 2020, 25(7), 1695; https://doi.org/10.3390/molecules25071695
Received: 2 March 2020 / Revised: 30 March 2020 / Accepted: 5 April 2020 / Published: 7 April 2020
(This article belongs to the Special Issue Biopolymers in Drug Delivery and Regenerative Medicine)
Biopolymer aerogels of appropriate open-porous morphology, nanotopology, surface chemistry, and mechanical properties can be promising cell scaffolding materials. Here, we report a facile approach towards the preparation of cellulose phosphate aerogels from two types of cellulosic source materials. Since high degrees of phosphorylation would afford water-soluble products inappropriate for cell scaffolding, products of low DSP (ca. 0.2) were prepared by a heterogeneous approach. Aiming at both i) full preservation of chemical integrity of cellulose during dissolution and ii) utilization of specific phase separation mechanisms upon coagulation of cellulose, TBAF·H2O/DMSO was employed as a non-derivatizing solvent. Sequential dissolution of cellulose phosphates, casting, coagulation, solvent exchange, and scCO2 drying afforded lightweight, nano-porous aerogels. Compared to their non-derivatized counterparts, cellulose phosphate aerogels are less sensitive towards shrinking during solvent exchange. This is presumably due to electrostatic repulsion and translates into faster scCO2 drying. The low DSP values have no negative impact on pore size distribution, specific surface (SBET ≤ 310 m2 g−1), porosity (Π 95.5–97 vol.%), or stiffness (Eρ ≤ 211 MPa cm3 g−1). Considering the sterilization capabilities of scCO2, existing templating opportunities to afford dual-porous scaffolds and the good hemocompatibility of phosphorylated cellulose, TBAF·H2O/DMSO can be regarded a promising solvent system for the manufacture of cell scaffolding materials. View Full-Text
Keywords: cellulose phosphate; cellulose phosphate aerogel; interconnected porosity; supercritical carbon dioxide; tetrabutylammonium fluoride; TBAF/DMSO cellulose phosphate; cellulose phosphate aerogel; interconnected porosity; supercritical carbon dioxide; tetrabutylammonium fluoride; TBAF/DMSO
Show Figures

Figure 1

MDPI and ACS Style

Schimper, C.B.; Pachschwoell, P.S.; Hettegger, H.; Neouze, M.-A.; Nedelec, J.-M.; Wendland, M.; Rosenau, T.; Liebner, F. Aerogels from Cellulose Phosphates of Low Degree of Substitution: A TBAF·H2O/DMSO Based Approach. Molecules 2020, 25, 1695. https://doi.org/10.3390/molecules25071695

AMA Style

Schimper CB, Pachschwoell PS, Hettegger H, Neouze M-A, Nedelec J-M, Wendland M, Rosenau T, Liebner F. Aerogels from Cellulose Phosphates of Low Degree of Substitution: A TBAF·H2O/DMSO Based Approach. Molecules. 2020; 25(7):1695. https://doi.org/10.3390/molecules25071695

Chicago/Turabian Style

Schimper, Christian B.; Pachschwoell, Paul S.; Hettegger, Hubert; Neouze, Marie-Alexandra; Nedelec, Jean-Marie; Wendland, Martin; Rosenau, Thomas; Liebner, Falk. 2020. "Aerogels from Cellulose Phosphates of Low Degree of Substitution: A TBAF·H2O/DMSO Based Approach" Molecules 25, no. 7: 1695. https://doi.org/10.3390/molecules25071695

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop