Next Article in Journal
Synergetic Improvement of Stability and Conductivity of Hybrid Composites formed by PEDOT:PSS and SnO Nanoparticles
Next Article in Special Issue
Development of RNA/DNA Hydrogel Targeting Toll-Like Receptor 7/8 for Sustained RNA Release and Potent Immune Activation
Previous Article in Journal
Amyloid-Beta1-42 -Induced Increase in GABAergic Tonic Conductance in Mouse Hippocampal CA1 Pyramidal Cells
 
 
Article

Design, Synthesis and Characterization of a Novel Type of Thermo-Responsible Phospholipid Microcapsule–Alginate Composite Hydrogel for Drug Delivery

1
Medical College, Hebei University, Baoding 071000, China
2
College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China
3
Intelligent Polymer Research Institute, AIIM Facility, University of Wollongong, Wollongong, NSW 2522, Australia
4
School of Life Science, Beijing Institute of Technology, Beijing 100081, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this article.
Molecules 2020, 25(3), 694; https://doi.org/10.3390/molecules25030694
Received: 14 December 2019 / Revised: 2 February 2020 / Accepted: 3 February 2020 / Published: 6 February 2020
(This article belongs to the Special Issue Biomedical Hydrogels: Synthesis and Applications)
Liposomes are extensively used in drug delivery, while alginates are widely used in tissue engineering. However, liposomes are usually thermally unstable and drug-leaking when in liquids, while the drug carriers made of alginates show low loading capacities when used for drug delivery. Herein, we developed a type of thermo-responsible liposome–alginate composite hydrogel (TSPMAH) by grafting thermo-responsive liposomes onto alginates by using Ca2+ mediated bonding between the phosphatidic serine (PS) in the liposome membrane and the alginate. The temperature-sensitivity of the liposomes was actualized by using phospholipids comprising dipalmitoylphosphatidylcholine (DPPC) and PS and the liposomes were prepared by a thin-film dispersion method. The TSPMAH was then successfully prepared by bridge-linking the microcapsules onto the alginate hydrogel via PS-Ca2+-Carboxyl-alginate interaction. Characterizations of the TSPMAH were carried out using scanning electron microscopy, transform infrared spectroscopy, and laser scanning confocal microscopy, respectively. Their rheological property was also characterized by using a rheometer. Cytotoxicity evaluations of the TSPMAH showed that the composite hydrogel was biocompatible, safe, and non-toxic. Further, loading and thermos-inducible release of model drugs encapsulated by the TSPMAH as a drug carrier system was also studied by making protamine–siRNA complex-carrying TSPMAH drug carriers. Our results indicated that the TSPMAH described herein has great potentials to be further developed into an intelligent drug delivery system. View Full-Text
Keywords: thermo-responsive liposome; phospholipid microcapsules; sodium alginate; hydrogel; protamine–siRNA complex; drug delivery thermo-responsive liposome; phospholipid microcapsules; sodium alginate; hydrogel; protamine–siRNA complex; drug delivery
Show Figures

Graphical abstract

MDPI and ACS Style

Ding, L.; Cui, X.; Jiang, R.; Zhou, K.; Wen, Y.; Wang, C.; Yue, Z.; Shen, S.; Pan, X. Design, Synthesis and Characterization of a Novel Type of Thermo-Responsible Phospholipid Microcapsule–Alginate Composite Hydrogel for Drug Delivery. Molecules 2020, 25, 694. https://doi.org/10.3390/molecules25030694

AMA Style

Ding L, Cui X, Jiang R, Zhou K, Wen Y, Wang C, Yue Z, Shen S, Pan X. Design, Synthesis and Characterization of a Novel Type of Thermo-Responsible Phospholipid Microcapsule–Alginate Composite Hydrogel for Drug Delivery. Molecules. 2020; 25(3):694. https://doi.org/10.3390/molecules25030694

Chicago/Turabian Style

Ding, Liang, Xinxia Cui, Rui Jiang, Keya Zhou, Yalei Wen, Chenfeng Wang, Zhilian Yue, Shigang Shen, and Xuefeng Pan. 2020. "Design, Synthesis and Characterization of a Novel Type of Thermo-Responsible Phospholipid Microcapsule–Alginate Composite Hydrogel for Drug Delivery" Molecules 25, no. 3: 694. https://doi.org/10.3390/molecules25030694

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop