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Open AccessArticle

In Vitro Antifungal Activity and Mechanism of Ag3PW12O40 Composites against Candida Species

1
School of Public Health, Jilin University, Changchun 130021, China
2
College of Material Science and Engineering, Jilin Jianzhu University, Changchun 130021, China
*
Author to whom correspondence should be addressed.
Academic Editor: Mauro Ravera
Molecules 2020, 25(24), 6012; https://doi.org/10.3390/molecules25246012
Received: 11 November 2020 / Revised: 15 December 2020 / Accepted: 16 December 2020 / Published: 18 December 2020
Fungal infections pose a serious threat to human health. Polyoxometalates (POMs) are metal–oxygen clusters with potential application in the control of microbial infections. Herein, the Ag3PW12O40 composites have been synthesized and verified by Fourier transform infrared (FT-IR) spectrum, transmission electron microscopy (TEM), scanning electron microscope (SEM), elemental analysis, and X-ray diffraction (XRD). The antifungal activities of Ag3PW12O40 were screened in 19 Candida species strains through the determination of minimum inhibitory concentration (MIC) by the microdilution checkerboard technique. The minimum inhibitory concentration (MIC50) values of Ag3PW12O40 are 2~32 μg/mL to the Candida species. The MIC80 value of Ag3PW12O40 to resistant clinical isolates C. albicans HL963 is 8 μg/mL, which is lower than the positive control, fluconazole (FLC). The mechanism against C. albicans HL963 results show that Ag3PW12O40 can decrease the ergosterol content. The expressions of ERG1, ERG7, and ERG11, which impact on the synthesis of ergosterol, are all prominently upregulated by Ag3PW12O40. It indicates that Ag3PW12O40 is a candidate in the development of new antifungal agents. View Full-Text
Keywords: polyoxometalates; pomposites; antifungal activity; ergosterol; RT-PCR polyoxometalates; pomposites; antifungal activity; ergosterol; RT-PCR
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MDPI and ACS Style

Zhang, X.; Zhang, T.; Guo, S.; Zhang, Y.; Sheng, R.; Sun, R.; Chen, L.; Lv, R.; Qi, Y. In Vitro Antifungal Activity and Mechanism of Ag3PW12O40 Composites against Candida Species. Molecules 2020, 25, 6012. https://doi.org/10.3390/molecules25246012

AMA Style

Zhang X, Zhang T, Guo S, Zhang Y, Sheng R, Sun R, Chen L, Lv R, Qi Y. In Vitro Antifungal Activity and Mechanism of Ag3PW12O40 Composites against Candida Species. Molecules. 2020; 25(24):6012. https://doi.org/10.3390/molecules25246012

Chicago/Turabian Style

Zhang, Xinming; Zhang, Tianzhan; Guo, Shuanli; Zhang, Yang; Sheng, Rongtian; Sun, Ruimeng; Chen, Lixia; Lv, Ruijuan; Qi, Yanfei. 2020. "In Vitro Antifungal Activity and Mechanism of Ag3PW12O40 Composites against Candida Species" Molecules 25, no. 24: 6012. https://doi.org/10.3390/molecules25246012

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