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Capsaicin and Gut Microbiota in Health and Disease

1
Division of Physiology and Neuroscience, Department of Functional Sciences, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania
2
Department of Cardiology, Emergency University Hospital of Bucharest, 050474 Bucharest, Romania
3
Department of Pediatric Gastroenterology, “Marie Curie” Children’s Clinical Hospital, 041434 Bucharest, Romania
*
Authors to whom correspondence should be addressed.
Academic Editors: Teodora Monica Neagu and Constantin Caruntu
Molecules 2020, 25(23), 5681; https://doi.org/10.3390/molecules25235681
Received: 31 October 2020 / Revised: 27 November 2020 / Accepted: 27 November 2020 / Published: 2 December 2020
Capsaicin is a widespread spice known for its analgesic qualities. Although a comprehensive body of evidence suggests pleiotropic benefits of capsaicin, including anti-inflammatory, antioxidant, anti-proliferative, metabolic, or cardioprotective effects, it is frequently avoided due to reported digestive side-effects. As the gut bacterial profile is strongly linked to diet and capsaicin displays modulatory effects on gut microbiota, a new hypothesis has recently emerged about its possible applicability against widespread pathologies, such as metabolic and inflammatory diseases. The present review explores the capsaicin–microbiota crosstalk and capsaicin effect on dysbiosis, and illustrates the intimate mechanisms that underlie its action in preventing the onset or development of pathologies like obesity, diabetes, or inflammatory bowel diseases. A possible antimicrobial property of capsaicin, mediated by the beneficial alteration of microbiota, is also discussed. However, as data are coming mostly from experimental models, caution is needed in translating these findings to humans. View Full-Text
Keywords: capsaicin; capsinoids; microbiota; antioxidant; antitumoral; energy metabolism; immune system; diabetes; obesity; inflammatory bowel disease capsaicin; capsinoids; microbiota; antioxidant; antitumoral; energy metabolism; immune system; diabetes; obesity; inflammatory bowel disease
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MDPI and ACS Style

Rosca, A.E.; Iesanu, M.I.; Zahiu, C.D.M.; Voiculescu, S.E.; Paslaru, A.C.; Zagrean, A.-M. Capsaicin and Gut Microbiota in Health and Disease. Molecules 2020, 25, 5681. https://doi.org/10.3390/molecules25235681

AMA Style

Rosca AE, Iesanu MI, Zahiu CDM, Voiculescu SE, Paslaru AC, Zagrean A-M. Capsaicin and Gut Microbiota in Health and Disease. Molecules. 2020; 25(23):5681. https://doi.org/10.3390/molecules25235681

Chicago/Turabian Style

Rosca, Adrian E., Mara I. Iesanu, Carmen D.M. Zahiu, Suzana E. Voiculescu, Alexandru C. Paslaru, and Ana-Maria Zagrean. 2020. "Capsaicin and Gut Microbiota in Health and Disease" Molecules 25, no. 23: 5681. https://doi.org/10.3390/molecules25235681

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