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Article

Correlations on Phenolic Screening Related to In Vitro and In Ovo Assessment of Ocimum basilicum L. Hydro-Alcoholic Extracts Used as Skin Active Ingredient

by
Alin Faur
1,†,
Claudia Watz
2,†,
Elena-Alina Moacă
3,*,
Ştefana Avram
4,
Florin Borcan
5,
Iulia Pinzaru
3,
Andrada Iftode
3,
Mirela Nicolov
2,
Ramona Amina Popovici
6,
Marius Raica
1,
Camelia A. Szuhanek
7 and
Cristina Dehelean
3
1
Department of Microscopic Morphology/Histology, Angiogenesis Research Center, Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania
2
Department of Pharmaceutical Physics, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania
3
Department of Toxicology and Drug Industry, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania
4
Department of Pharmacognosy, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania
5
Department of Analytical Chemistry, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania
6
Department of Management, Legislation and Communication in Dentistry, Faculty of Dentistry, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania
7
Department of Orthodontics, Faculty of Dental Medicine, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Molecules 2020, 25(22), 5442; https://doi.org/10.3390/molecules25225442
Submission received: 29 October 2020 / Revised: 17 November 2020 / Accepted: 17 November 2020 / Published: 20 November 2020
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Abstract

The current study was aimed to evaluate the phenolic composition parameters of two hydro-alcoholic extracts of Ocimum basilicum L. (OB) obtained from the aerial part (without leaves) and leaves, in order to determine their contribution to the antioxidant activity (AOA). Both hydro-alcoholic extracts have proven to be rich in polyphenolic compounds, flavonoids, flavonols and tannins. Therefore, the leaves’ extracts reveal an inhibition percentage of 89%, almost comparable with the standard reference (95%). To complete the toxicological profile, the study also assessed the potential cytotoxicity of basil hydro-alcoholic extracts on immortalized human keratinocytes (HaCaT), skin human fibroblasts (1BR3), mice epidermis (JB6Cl41-5a) and primary human melanocytes (HEMa) cells, correlated to A375 antitumor in vitro activity. The extracts did not induce significant cytotoxic effect on any of the selected normal cell lines but showed relevant activity on A375 cells. Considering the low values obtained regarding the irritative effects in the chorionallantoic membrane of the egg on blood vessels, we can emphasize that both extracts can be considered as biocompatible ingredients. Regarding the potential activity of hydro-alcoholic extracts on human skin, the decrease of erythema values after the application of extracts was a relevant observation which indicates the anti-inflammatory potential of Ocimum basilicum L.
Keywords: basil; DPPH; phenolic composition; cell viability; skin irritation; CAM assay basil; DPPH; phenolic composition; cell viability; skin irritation; CAM assay

Share and Cite

MDPI and ACS Style

Faur, A.; Watz, C.; Moacă, E.-A.; Avram, Ş.; Borcan, F.; Pinzaru, I.; Iftode, A.; Nicolov, M.; Popovici, R.A.; Raica, M.; et al. Correlations on Phenolic Screening Related to In Vitro and In Ovo Assessment of Ocimum basilicum L. Hydro-Alcoholic Extracts Used as Skin Active Ingredient. Molecules 2020, 25, 5442. https://doi.org/10.3390/molecules25225442

AMA Style

Faur A, Watz C, Moacă E-A, Avram Ş, Borcan F, Pinzaru I, Iftode A, Nicolov M, Popovici RA, Raica M, et al. Correlations on Phenolic Screening Related to In Vitro and In Ovo Assessment of Ocimum basilicum L. Hydro-Alcoholic Extracts Used as Skin Active Ingredient. Molecules. 2020; 25(22):5442. https://doi.org/10.3390/molecules25225442

Chicago/Turabian Style

Faur, Alin, Claudia Watz, Elena-Alina Moacă, Ştefana Avram, Florin Borcan, Iulia Pinzaru, Andrada Iftode, Mirela Nicolov, Ramona Amina Popovici, Marius Raica, and et al. 2020. "Correlations on Phenolic Screening Related to In Vitro and In Ovo Assessment of Ocimum basilicum L. Hydro-Alcoholic Extracts Used as Skin Active Ingredient" Molecules 25, no. 22: 5442. https://doi.org/10.3390/molecules25225442

APA Style

Faur, A., Watz, C., Moacă, E.-A., Avram, Ş., Borcan, F., Pinzaru, I., Iftode, A., Nicolov, M., Popovici, R. A., Raica, M., Szuhanek, C. A., & Dehelean, C. (2020). Correlations on Phenolic Screening Related to In Vitro and In Ovo Assessment of Ocimum basilicum L. Hydro-Alcoholic Extracts Used as Skin Active Ingredient. Molecules, 25(22), 5442. https://doi.org/10.3390/molecules25225442

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