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Article

Rose (Rosa gallica) Petal Extract Suppress Proliferation, Migration, and Invasion of Human Lung Adenocarcinoma A549 Cells through via the EGFR Signaling Pathway

1
Korea Food Research Institute, Wanju-gun, Jeollabuk-do 55365, Korea
2
Department of Food Science & Biotechnology, Sejong University, Gwangjin-gu, Seoul 05006, Korea
*
Author to whom correspondence should be addressed.
Academic Editors: Thea Magrone and Rodrigo Valenzuela
Molecules 2020, 25(21), 5119; https://doi.org/10.3390/molecules25215119
Received: 16 September 2020 / Revised: 21 October 2020 / Accepted: 26 October 2020 / Published: 4 November 2020
We sought to investigate the effect of rose petal extract (RPE) on the proliferation, migration, and invasion of cancer cells. RPE significantly inhibited the growth of lung and colorectal cancer cell lines, with rapid suppression of A549 lung cancer cells at low concentrations. These effects occurred concomitantly with downregulation of the cell proliferation mediators PCNA, cyclin D1, and c-myc. In addition, RPE suppressed the migration and invasion of A549 cells by inhibiting the expression and activity of matrix metalloproteinase-2 and matrix metalloproteinase-9 (MMP-2 and -9). We hypothesize that the suppressive activity of RPE against lung cancer cell proliferation and early metastasis occurs via the EGFR-MAPK and mTOR-Akt signaling pathways. These early results highlight the significant potency of RPE, particularly for lung cancer cells, and warrant further investigation. View Full-Text
Keywords: anticancer; invasion; migration; phytochemicals; proliferation; rose petal extract anticancer; invasion; migration; phytochemicals; proliferation; rose petal extract
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MDPI and ACS Style

Lim, W.-C.; Choi, H.-K.; Kim, K.-T.; Lim, T.-G. Rose (Rosa gallica) Petal Extract Suppress Proliferation, Migration, and Invasion of Human Lung Adenocarcinoma A549 Cells through via the EGFR Signaling Pathway. Molecules 2020, 25, 5119. https://doi.org/10.3390/molecules25215119

AMA Style

Lim W-C, Choi H-K, Kim K-T, Lim T-G. Rose (Rosa gallica) Petal Extract Suppress Proliferation, Migration, and Invasion of Human Lung Adenocarcinoma A549 Cells through via the EGFR Signaling Pathway. Molecules. 2020; 25(21):5119. https://doi.org/10.3390/molecules25215119

Chicago/Turabian Style

Lim, Won-Chul, Hyo-Kyung Choi, Kyung-Tack Kim, and Tae-Gyu Lim. 2020. "Rose (Rosa gallica) Petal Extract Suppress Proliferation, Migration, and Invasion of Human Lung Adenocarcinoma A549 Cells through via the EGFR Signaling Pathway" Molecules 25, no. 21: 5119. https://doi.org/10.3390/molecules25215119

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